GlycoFi and Dartmouth report full humanization of yeast glycosylation pathway in Science
...t cells capable of producing a broad repertoire of recombinant therapeutic proteins with fully human sugar struct...trate the utility of the engineered yeast strains, recombinant erythropoietin (Epo), a protein that stimulates the production of red blood cells, was expressed, pu......ildren's Hospital Oakland Research Institute has a recombinant DNA library with more than 30 million DNA samples ...l research in the genetics of human diseases. The recombinant DNA library is, for example, being used in Oakland to investigate the genetic differences that make ...Replacing insulin is top-ranked breakthrough foreseen for health in developing world
...Shantha Biotechnics, for instance, has developed a recombinant hepatitis B vaccine that sells for only $US O.40 per dose as compared to imported vaccines which sell for $US 8-10 per dose." Leaders among developing countries in their level of regenerative medicine activity are India, China and Brazil. The aut...UCLA neuroscience research leads to a possible treatment for type 1 diabetes
..." Arnold said. In the 1980s, using newly developed recombinant DNA techniques, Tobin's laboratory was studying ge...ny laboratories throughout the world are now using recombinant GAD to determine whether individuals have autoantibodies to GAD and are likely to develop diabetes. ...New study pinpoints unique genetic susceptibility for viral encephalitis
...ications-some of these patients could benefit from recombinant interferon alpha (IFN-?) treatment, just as patients with low levels of naturally occurring interferon gamma (IFN-?) benefit from a similar life-saving approach." Herpes simplex virus-1 is a common virus that infects about 80 percent of young adults...'Failed' experiment yields a biocontrol agent that doesn't trigger antibiotic resistance
...bacterium. The host bacterium then replicates the recombinant plasmid and transfers copies of it to other bacteria in a process called conjugation. As he investigated the failed experiment, Filutowicz - who has spent two decades studying how plasmid replication is regulated - made a critical observation. A pl...Vaccine-producing 'plant-factories'
...asts of the plant cell. Some of these glycosylated recombinant proteins have significant antigenic power of great... accumulate very limited quantities of glycosylate recombinant proteins. The chloroplast is a cell organ with great capacity for storing proteins. However, it is i......outbred, heterogeneous stock (HS) and the other of recombinant inbred lines (RI). Using the single nucleotide polymorphism (SNP) data that resulted from physical mapping of the mouse genome, the authors were able to track the patterns of inheritance of >10,000 SNPs in both groups of mice. Next, they were abl...Other highlights in the November 15 JNCI
...on University in Philadelphia, and colleagues gave recombinant endorepellin to mice with human skin and lung tumors. They found that endorepellin targeted the tumors' vascular system. They suggest the result may help in the development of effective anti-cancer therapies. Contact: Renato V. Iozzo, 215-503-2208...Study uncovers mutation responsible for Noonan Syndrome
...on crystal structures of SOS1, the scientists made recombinant versions of the mutants and expressed them in mammalian cells, where it was discovered that they promoted excessive activation of RAS and its downstream target, MAP kinase, the same pathway activated by PTPN11 mutations. "These results are the firs...Tips from the Journals of the American Society for Microbiology
...roneedle-based intradermal delivery of the anthrax recombinant protective antigen vaccine. Infection and Immunity, 74. 12: 6806-6810.)...Stanford discovery may help predict when toxoplasma can be deadly
...ts to eat. The researchers then took the resulting recombinant strains from the cats and infected other mice with them. Based on how these mice fared, the researchers could pinpoint stretches of DNA that contain the genes underlying severe virulence. Based on the DNA sequences, they could determine the proteins ...Cellular pathway yields potential new weapon in vaccine arsenal
...for vaccine development," Mnz says, especially for recombinant viral vaccines like those against HIV. "Killer T cell responses are usually short-lived. But if you can increase recognition by helper T cells, then you'll be more likely to maintain the killer T cell response and establish immunological memory."...Erythrocyte G protein as a novel target for malarial chemotherapy
...accine efficacy in senescen t mice challenged with recombinant SARS-CoV bearing epidemic and zoonotic spike variants. PLoS Med 3(12): e525. PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPO RT: http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pm...Maxine Singer awarded 2007 NAS Public Welfare Medal
...was among the first to publicly raise the issue of recombinant DNA's potential risks, and advocated for self regu...silomar established a framework for the conduct of recombinant DNA research, and cleared the way for the gradual relaxation of restrictions as understanding progre...Maxine F. Singer to receive Public Welfare Medal
...he first to bring to public attention the issue of recombinant DNA's potential risks and quickly became a leader in the scientific community's important efforts to regulate itself. She was a key organizer of and contributor to the pathbreaking 1975 Asilomar Conference. Attended by 140 biologists, physicians, l...Bioengineering efficient antibiotic biosynthesis in E. coli
...6-deoxyerythromycin D antibiotic. By engineering a recombinant strain of E. coli that produces the bioactive macr...ring of this class of antibiotics. Initially, this recombinant strain produced barely enough antibiotic activity to establish an activity-based screening assay. Th...Scientists find hormone activity explains adolescent mood swings
... Smith and colleagues identified the site on human recombinant alpha4-beta2-delta GABA-A receptors that produced the anxiety response, and were able to mutate the site to prevent the novel effect of the stress hormone. In contrast, neither the receptor nor the necessary conditions exist for this anxiety-producin...'Combination' Lyme disease vaccine proteins patented
...ese life cycle stages, Dunn's team used methods of recombinant DNA to create new proteins that combine the most immunogenic portions of OspA and OspC that is, the regions of the two proteins that are most likely to trigger an immune response. The researchers have demonstrated that the new combination proteins...India's biotech industry emerging as world innovator, collaborator, competitor
... UNICEF at those prices. Shantha also priced its recombinant interferon alpha (IFN-) product Shanferon at about...oped a proprietary process for manufacturing human recombinant insulin. Even before Biocons product (Insugen) entered the domestic market, international compet...