Reconstructed 1918 influenza virus induces immune response that fails to protect
...esearch team, many of whom had collaborated on the reconstruction of the 1918 influenza virus, wanted to know why the virus, which killed 20 to 40 million people, was so lethal. In the study, researchers infected one group of mice with the reconstructed 1918 influenza virus and a second group with benign human infl...New type of optical microscopy attains near-molecular resolution
...ark Bates at Harvard, describes stochastic optical reconstruction microscopy, or STORM, in the Aug. 9 online edition of the journal Nature Methods. "We believe this technique has the potential to transform molecular and cellular imaging in biology," says Zhuang, an HHMI investigator and professor of chemistry and...SNM honors outstanding contributors
... spatial-resolution and scatter; tomographic image reconstruction for SPECT and PET; assessment of image quality by task performance studies using human and numerical observers; quantization of activity and assessment of function; and image segmentation and computer vision applications in nuclear medicine. The Ed...Journal of Nuclear Medicine publishes NCI-sponsored guidelines for using FDG PET
...f FDG PET (patient preparation; image acquisition, reconstruction and analysis; and quality assurance) and provide a valuable reference for incorporating PET into clinical trials. "There should be less variability in the performance of FDG PET in clinical trials by enacting these recommendations," explained prin...Afghanistan to protect wildlife and wild lands
...versity is an important element of USAID's overall reconstruction program in the country," said Alonzo Fulgham, Mission Director, USAID/Afghanistan. "We are pleased that one of the premier conservation organizations in the world, the Wildlife Conservation Society, will be partnering with us in this effort." The...Rare disease's gene may illuminate major disorders
... an enzyme that breaks down lipids involved in the reconstruction of a cell's membrane following damage by light and other toxins. When the gene is mutated, lipid metabolism is altered and iron builds up, triggering disease. "I studied our entire INAD patient population for mutations in this gene and found over 44 ...When it counts: Shortening imaging time for individuals with suspected heart problems
...can be cut in half using a trademarked, innovative reconstruction technology. These results--from researchers at Car...ter can be used to apply a tomographic (sectional) reconstruction algorithm to the multiple projections, yielding 3-D information. Physicians will use this informatio...Just-right PET/CT imaging for patients of all sizes
...ns simultaneously. Using this information in image reconstruction translates into improved image quality, which lead...information has not traditionally been used in the reconstruction of the PET image data. With time-of-flight, this time difference can be measured with reduced uncert...UCLA biomathematician earns prestigious peer award
...entists avoided troublesome biases in evolutionary reconstruction that occur when assuming these relationships are known. Suchard and Redelings' findings about early branches in the evolutionary tree of life were published in the June 2005 edition of the journal Systematic Biology. "Dr. Suchard is an accomplished s...Historic Colorado River streamflows reconstructed back to 1490
A new tree-ring-based reconstruction of 508 years of Colorado River streamflow confirms... work updates the original landmark Colorado River reconstruction that was done at The University of Arizona's Laboratory of Tree-Ring Research," said David M. Meko, ...Giant deep-sea tubeworm's meal ticket comes in as a skin infection
...escence- and electron microscopy. By a painstaking reconstruction of electronmicrographs of thin slices of larvae andjuvenile worms, the team showed that thesymbionts do not enter through the mouth, butthrough the skin, in a process akin toinfection by pathogenic bacteria. Thesebacterial partners then crawl inward,...Unraveling the viral mechanism
...olecular Biophysics (SCBMB), developed a new image reconstruction algorithm. These developments enabled him and his co-authors at MIT to see through the bacteriophage at very high resolution. "It turns out that, in addition to the surface protein, there are other proteins that make this virus viable," said Chiu...MIT researcher finds neuron growth in adult brain
...her two-dimensional slices to create the first 3-D reconstruction of entire neurons in the adult cortex. Dendritic branch tips were measured over weeks to evaluate physical changes. What the researchers saw amazed them. In 3-D time-lapse images, the brain cells look like plants sprouting together. Some push out ...A year on from the Asian tsunami, satellites are aiding regional rebuilding
...phase and also in the recovery, rehabilitation and reconstruction phases. Damage mapping products maps were provide...ps extensively to supervise, direct and manage its reconstruction operations in the Calang area of Sumatra. Meanwhile the town of Sigli in the east of Sumatra's Aceh...Tsunami + 1 year: Reviving exhausted fisheries should trump replacing boats, gear, experts say
...ommunities to ensure sustainable livelihoods. "The reconstruction phase following the tsunami, however, has created a window of opportunity to institute reforms needed for the long-term," says Dr. Hall. "Armed with good intentions and awash with money, but without clear co-ordination and a coherent strategy, many o...How E. coli bacterium generates simplicity from complexity
...oli and other model organisms, but our large-scale reconstruction of regulatory and metabolic networks involving hundreds of these parts has shown that all this genetic complexity yields surprisingly few physiological functions. This is possibly a general principal in many, if not all, species." Palsson and his col...Picking particles faster than one at a time
...some structure is known in detail. Single-particle reconstruction with cryo-EM holds the promise of providing many high-resolution structures which may be difficult or impossible to obtain otherwise. Instead of trying to coax molecules to arrange themselves in a repeating crystalline structure, as is necessary for...Targeted drug delivery achieved with nanoparticle-aptamer bioconjugates
...o used high magnification microscopy and 3-D image reconstruction to study the localisation of the bioconjugates after incubation with the prostate cancer cells and confirmed that the particles were rapidly internalised into the targeted cells an important fact since the payload of nanoparticles may be released in...What mutations tell us about protein folding
... the observed changes in the folding times? Such a reconstruction clearly requires experimental data on a large number of mutants. In the traditional interpretation, the structural information is extracted for each mutation, independent of the other mutations. If a mutation does not change the folding time, then th......em Cell Dynamics, recognized for research into the reconstruction of injured tissues and organs....