Muscular dystrophy and cancer-associated muscle wasting share dystrophin dysfunction
...atients with gastrointestinal cancers had dramatic reductions in dystrophin when compared to weight-stable healthy individuals. Although cancer cachexia and muscular dystrophy both involve muscle loss, the mechanisms underlying these diseases had been thought to be widely divergent. However, the results of thi...Cancer wasting, muscular dystrophy show common change
...firmed cachectic, and ten of those showed dramatic reductions in dystrophin and significant loss of the DGC. Overall, Guttridge says, "our evidence strongly suggests that the loss of dystrophin and the DGC are important contributing factors in tumor-induced muscle wasting."...Research: In environmental policy, we get what we pay for
... carbon dioxide allowances. Our ability to measure reductions in emissions, or "carbon sinks" that absorb greenh...to enforce and lead to more certainty in emissions reductions than market approaches when measuring emissions is uncertain. In situations where it doesn't matter ......f human tissues and cells may also lead to further reductions in donor treatment activity. On the other hand, the demand for donor sperm is likely to increase because of a possible decline in the semen quality in the general UK population." The potential gap between supply and demand has led senior author Dr Ja...Other highlights in the October 19 JNCI
...y or C225 only, C225 plus PDT produced synergistic reductions in mean tumor burden and improvements in survival. In an editorial, Eli Glatstein, M.D., of the University of Pennsylvania in Philadelphia, and colleagues discuss the theoretical advantages of using C225 and PDT to exploit different aspects of ovari...Russian 'surrogate' alcohols are a killer
...n that was launched in May 1985; it included heavy reductions in alcohol production and sales, an increase in alcohol prices, a strengthening of mandatory treatment of alcoholism, and enforcement of measures against home production. Results were swift. From 1985 to 1987, life expectancy increased by 3.2 years...Sept/Oct 2005 Annals of Family Medicine tip sheet
...actually decrease the overall cost of care through reductions in spending on diagnostic testing. The authors assert that this should reassure those who fear that patient-centered physicians would try to fulfill all patient requests. However, the authors also noted that patient-centered physicians take more ti...Chernobyl: The true scale of the accident
...ecay, migration of radionuclides down the soil and reductions in bioavailability have led to a significant reduc... of radiocaesium from fodder to milk) led to large reductions in contamination and permitted agriculture to continue, though some increase in radionuclide content...The 'been there, done that' memory response
...s of perceived memory strength suggest that graded reductions in medial temporal cortical responses support graded perceptions of item familiarity, providing a basis for such discriminations. As such, medial temporal mechanisms appear to rapidly signal knowledge about an item's relation to one's past."...A giant sucking sound for sea turtles
... Campbell, the lead author of the study. "Drastic reductions are needed in fishing levels, or both the turtles - and turtle fishers - will vanish within a matter of years." Although protected from international trade by CITES - the Convention on International Trade in Endangered Species, an estimated 11,000 gr...Gene changes linked to deficient immune suppression in MS
...es in FOXP3 mRNA and protein expression as well as reductions in suppressive activity. FOXP3 has been shown in several studies to be an unequivocal marker for T-reg cell function mice and humans lacking the gene are susceptible to a fatal autoimmune lymphoma. But no studies have, until now, shown that the dro...Exposure to sunlight may decrease risk of prostate cancer
...lly melanoma. "If future studies continue to show reductions in prostate cancer risk associated with sun exposure, increasing vitamin D intake from diet and supplements may be the safest solution to achieve adequate levels of vitamin D," they said. The researchers compared 450 non-Hispanic white patients in th...National medical, nursing and public health groups file suit
...tion of America's children. It delays significant reductions in mercury pollution from power plants by at least 10 to 15 years, and allows dangerous levels of mercury to spew unabated with a 'cap and trade' pollution control standard. The EPA is required by the Clean Air Act to protect public health to the gre...Cranberry juice inactivates intestinal viruses
...e cocktail to intestinal viruses resulted in viral reductions below detectible infectivity levels," says Patrice Cohen, a researcher on the study. Intestinal virus infections account for significant illness and billions of dollars in medical expenses each year in the United States and throughout the world. O...Virus uses tiny RNA to evade the immune system
...oRNA than the normal virus. Thus, microRNA-induced reductions in T antigen expression promote escape from antiviral T cells without affecting virus growth. "Viruses can use the host RNA inference machinery, which is often speculated to have evolved as an antiviral mechanism, to generate small RNAs that serve th...Large community-based clinical trial in older cancer patients suggests benefits of Neulasta
...cycle of myelosuppressive chemotherapy resulted in reductions in febrile neutropenia (low white blood cell count...well as a 50 percent decrease in chemotherapy dose reductions (7 percent versus 14 percent) in patients receiving Neulasta beginning in the first cycle of chemoth...Changes in community size affect the outcome of competition
...gmented by anthropogenic activities, because rapid reductions in the size of communities make it relatively more likely that inferior exotic species will usurp native species, even if natives are better competitors. Given ongoing habitat change and the incalculable costs of biological invasions, stochasticity m...Researchers observe predictors of natural immunity to ovarian cancer
...MUC1 antibodies resulted in correspondingly higher reductions in ovarian cancer risk. Women who experienced two events leading to elevated MUC1 antibody levels were about 30 percent less likely to develop ovarian cancer than women with none or only one MUC1 antibody-promoting event, the study showed. Those th...Two-part blood pressure control suggests new approach to hypertension therapy
...atment regimens. For example, it might explain why reductions in dietary salt effectively lower blood pressure for some people, but not others, they said. Through a series of kidney transplantation experiments involving both normal mice and mice in which a critical molecular component of blood pressure regulati...Regular exercise helps protect muscles in elderly from soreness, injury
...p with their training program, there were dramatic reductions in the amount of muscle tissue injuries the animals had by the end of the study," Devor said. "This suggests that, in older adults, regular exercise may help prevent injuries associated with age-related impairments such as reduced muscle strength, im...