Laser scalpel opens way for nerve regeneration studies in worms
...ed that the severed nerves of worms are capable of regenerating and regaining full function.According to the researchers, studying nerve regeneration in the worm could provide answers to questions that are not accessible currently by doing experiments in more complex animals, including mice and zebrafish.A resear...Research identifies promising route for treating age-related hearing loss
...ich could lead to eventual clinical application in regenerating lost hair cells," said Corey. According to Corey, the findings also have important implications for basic research. "A major obstacle to hair-cell research has been that, since there are not very many hair cells in the inner ear, it has been hard to...New component of the 'brakes' on nerve regeneration found
Among the principal obstacles to regenerating spinal cord and brain cells after injury is the "braking" machinery in neurons that prevents regeneration. While peripheral nerves have no such machinery and can readily regenerate, central nervous system (CNS) neurons have their brakes firmly in pla...New Georgia Tech micro-CT imaging technique to help tissue engineers improve bone regeneration
...e process by which mineral crystals form to harden regenerating bone) by collecting three-dimensional images in vitro and in vivo. Georgia Tech researchers used the new technique to help develop bone graft substitutes that combine the availability and structural integrity of bone allografts, or bone grafts taken ...For first time, brain cells generated in a dish
...the cells to generate specific neurons. "As far as regenerating parts of the brain that have degenerated, such as in Parkinson's disease, Huntington's disease and others of that nature, the ability to regenerate the needed cell type and placing it in the correct spot would have major impact," said Dr. Eric Hollan...Researchers find molecule that inhibits regrowth of spinal nerve cells
... major role in inhibiting spinal-cord neurons from regenerating after injury, researchers at UT Southwestern Medical Center have found.In cultured cells, the researchers found that a component of myelin a substance that normally insulates and stabilizes long nerve fibers in adult vertebrates chemically blocks t...Tissue regeneration operates differently than expected
...s rather than by simply becoming components of the regenerating organ. (Genes & Development, August 2005). Stem c...into muscle cells. By fusing with the cells of the regenerating tissue these cells rather seem to only simulate such a transdifferentiation mechanism. This has majo......ely integrated with their surrounding matrix, when regenerating tissues it is logical to provide cells with the correct niche to help them develop in the right way. That's where our research into the cell matrix comes in." "The work done here impinges on virtually all human diseases, although we have specific int...Coastal retreat in face of rising sea levels found to be influenced by wildfires
...e found only marsh grasses growing and no signs of regenerating pine seedlings. He hypothesized that, in the absence of trees to release water vapor into the air, the water table had moved upward. Attempting to explain the lack of forest regeneration, Poulter initially hypothesized that when marsh grass species ...Bone marrow stem cells may heal hearts even years after heart attacks
...of cell transplantation that is most efficient for regenerating damaged myocardium." Roberto Bolli, M.D., F.A.C.C., from the University of Louisville in Louisville, Kentucky, who co-authored an editorial appearing in the journal, wrote that a "veritable revolution" is underway to overthrow the belief that heart m...Scientists crack code for motor neuron wiring
...ce to believe this -- so all you need to do is get regenerating axons to grow past the site of the lesion. "Or, it could be that injury causes subtle alterations in the wiring of spinal circuits, and these alterations may constrain the capacity for full recovery of motor function. So, the more that is understood ...New understanding of regeneration gained by Forsyth scientists
...d an imposition of the correct morphology upon the regenerating tissue. Understanding this process is crucial for both the basic biology of pattern formation, and for developing novel biomedical approaches. Planaria have powerful regeneration capability that makes them ideal for studying this process. When the w...Regenerating worms help elucidate stem cell biology
...ers, zebrafish, and other organisms are capable of regenerating entirely new body parts. Although the human body does not face such demands, it is constantly replacing lost cells. For example, blood replenishes itself, wounds heal, and the lining of the gut sloughs off and is restored. Nowhere, however, is the pr...UCSF study finds nerve regeneration is possible in spinal cord injuries
...of the spinal cord injury, but more important, the regenerating axons grew back into normal areas of the spinal cord, where the hope is that functional connections can be reestablished. Axons are the long, fragile, fibers that conduct impulses between nerve cells in the brain, spinal cord and limbs. "Getting th...Mutation in blood stem cells provides clues to cancer development
... "There are primal pathways that are important for regenerating cells and tissues, and those are the same pathways that cancers use, subverting normal processes and using them for the wrong purpose. The discovery of this mutation means we can look toward interrupting these pathways, systematically, without wipin...Bile acids, receptor key in regenerating livers
... they may have been on the right track. In fact, regenerating liver tissue may depend on signals sent out when t...ration." Animals bred to lack FXR have difficulty regenerating liver, he said. And when he and his colleagues fed animals a diet that contains bile acids, the live...OHSU study says stem cell 'fusion' occurs in tumors
...ng the molecular mechanisms that may be at work in regenerating rapidly turning over damaged tissue, or may even be implicated in disease progression. "The intestinal lining is the protective barrier between your body and the outside environment. Therefore, it sees all of the offensive contaminants that you inges...UCSF Institute for Regeneration Medicine receives gift from Dolbys
...l differentiation and exploring the possibility of regenerating tissues destroyed by diseases and traumatic injuri...se -- to fuse with liver cells, with an eye toward regenerating diseased livers and other tissues. Scientists who focus on broad phenomena of cell development, such...New study reveals signaling pathways required for expansion of pancreas stem cells
...t the Sarvetnick lab used contains an abundance of regenerating stem cells from the ducts. "Importantly, we found that if we inject an antibody that inhibits BMP4 into these mice, this significantly reduced the number of proliferating duct cells. We also found that in these mice inhibition of BMP4 results in an i......on the Sv129 background had two to four times more regenerating fibers caudal to the lesion than BL/6 mice. Dorsal root ganglia explants from wild-type Sv129 mice also displayed more neurite outgrowth than those from BL/6 mice. The two strains also displayed a dizzying array of differences in mRNA expression patt...