DNA sequence controls expression of gene involved in cancer
...ich sequence of nucleotides in the 3' untranslated region of the bcl-2 mRNA. This sequence, called the AU-ri...A, resulting in its degradation. A report that a region of RNA upstream of the ARE also affects mRNA stability motivated Dr. Jeong-Hwa Lee and his colleague...Fungus knocks a frog down but not out, raising questions about amphibian declines
...disease persists and spreads from frog to frog and region to region. "T. eungellensis seems to have been 'lucky' in terms of having at least survived the fungus," Retallick noted, "but another species living beside it -- the Gastric Brooding Frog -- wasn't. If you do have a situation where all t...Brain circuit may permit scientists to eavesdrop on memory formation
...ajor learning-related area of the brain to another region that governs the brain's higher functions. The studies open the way for eavesdropping on one of the central processes in learning and memory, says HHMI investigator Erin M. Schuman . She and Miguel Remondes of the California Institute of Technology ...Interactive health information system to detect Japanese encephalitis in Asia
...a safe and effective vaccine to eventually rid the region of this disabling and deadly disease. The Voxiva system is able to quickly spread the word about new vaccines as they become available. ...Is more better: Counting birds may only tell part of the story
...al conservation. A large population of birds in a region could indicate a suitable habitat, or it could, in fact, could be the only place the animals could find, wrong for feeding, mating, and rearing young, in other words, an "ecological trap." "Ornithologists and ecologists in Europe and North Ameri...Drought in the West linked to warmer temperatures
...sed prevalence of drought in the western, interior region of North America. Looking at implications for the future, the authors express concern. "Any trend towards warmer temperatures in the future could lead to a serious long-term increase in aridity over Western North America," they write in the paper. ...Technique for genetically modifying blood stem cells brings cure for blood diseases closer
...mal chromosome containing the globin locus control region (LCR), which has overall operational control over the expression of the gene. The St. Jude team used these regulatory elements that normally control the beta-globin gene and put them into the vector with the gamma-globin gene. The entire vector, name...Where in the brain decisions are made
...used a game-playing approach to demonstrate that a region of the cortex called the lateral intraparietal (LI...l activity of neurons in the lateral intraparietal region did indicate that it was involved in making those decisions. Analysis of the experiments also indica...Perceptual decision-making hub pinpointed in human brain
...explained Heekeren. "Responses of each specialized region may differ by only a little bit, and so it takes the brain longer to weigh each signal and make a decision." The dorsal lateral prefrontal cortex site is also activated by other tasks, suggesting that it likely has general decision-making func...Researchers find protein that makes long-term memory possible
...electrical impulses. The brain slices come from a region of the brain known as the hippocampus, believed to be involved in forming long-term memories. When the hippocampal cells are stimulated with a specific pattern of electric signals, they begin to transmit the stronger electric signals characteristic ...Scientists identify new cause of obesity
...MC4R, is a receptor on neurons in the hypothalamus region of the brain and receives signals through at least two pathways about the status of the body's fat reserves. If fat stores are increasing, theses signals stimulate MC4R, triggering physiological responses that decrease appetite. If fat reserves are d...UCSD medical researchers use brain cell transplants to correct muscle spasms after aneurysm surgery
... well defined human neuronal cells into a specific region of the spinal cord can be an effective treatment for spasticity in cases of ischemic spinal cord injury," said the study's lead author, Martin Marsala, M.D., UCSD associate professor of anesthesiology. "While we believe the transplantation may reliev...Zebrafish may offer researchers powerful new tool for studying innate immunity
...tion of the NITR genes is very similar to variable region genes of antibodies and T-cell receptors, but the NITR genes do not undergo the complex genetic rearrangements of these adaptive receptors. "The comprehensive definition of the NITR gene cluster in zebrafish reported in this paper represents a signi...Mouse study: 'Critical' Down syndrome region isn't
...pkins researchers report that a particular genetic region long assumed to be a critical factor in Down syndr...ce, shreds a 30-year-old notion that genes in this region are largely responsible for the condition's characteristic facial features and some of its other com...Single genetic defect links many risk factors for heart disease and stroke
...acid isoleucine. That defect distorted the docking region of the tRNA, preventing it from recognizing and attaching to the messenger RNA to deposit its isoleucine cargo. Thus, the faulty tRNA could lead to defects in a vast array of proteins that normally contain isoleucine, thereby contributing to a broad ...Newly discovered protein suggests novel tumorigenic pathway
...degradation of PTEN in cells, indicating that this region is critical for ensuring PTEN stability. Studies have shown that cells add phosphate molecules to specific serine and threonine residues within the C-terminal segment to stabilize PTEN. Curious about the proteins involved in this stabilization, Dr...Researchers discover gene mutations for Parkinson's disease
...ory of Parkinson's disease who lived in the Basque region of Spain and in England. First, the group identified a small region of the chromosome 12 shared by all of the Basque families and then systematically assessed each gene...Gene for common form of Parkinson's pinpointed
...chers had identified four families from the Basque region of Spain and one from the United Kingdom that showed evidence of having PARK8 PD. Their systematic analyses of the PARK8 locus led them to track down mutations that all had in the gene encoding dardarin. Evidence implicating dardarin includes the......at causes autism, they had identified a particular region of a chromosome that is inherited by autistic chil...n than their nonautistic siblings--a clue that the region contributes to the disease. Millonig and Brzustowicz realized that this identified region contains t...Early life stress harms mental function and immune system in later years
...on between brain cells in the hippocampus, a brain region involved in learning, storage, and recall of memories. Kristen Brunson, a senior member of Tallie Z. Baram's group, and her colleagues, found that limiting the nesting material in cages where neonatal rats lived with their mothers led to emotio...