Commandeering cellular machinery: recognition mechanism to detect small molecules
...logy could also be used to produce enzymes, and to regulate metabolism in cells, Doyle said. Having demonstrated the ability to re-engineer one nuclear receptor to respond to a small molecule to which it previously did not bind, the research team next wants to demonstrate that the technique could apply to oth...Below the surface: New clues to plant signaling from the roots
...l point that, while originating in the root, helps regulate the critical early days of leaf development. How p...of the plant, may also provide growth signals that regulate shoot growth, but researchers are only beginning to understand the ways in which roots are able to e...Irwin Rose wins 2004 Nobel Prize in Chemistry
...ers, similar to ubiquitin, are used by the cell to regulate proteins in many ways. These findings are playing a key role in the development of drugs to fight illnesses such as cancer and cystic fibrosis. "The basic science faculty at the College of Medicine and our clinical faculty at UCI Medical Center a...NIH awards Emory and Georgia Tech $10 million for partnerships in cancer nanotechnology
...nvolved in transporting the proteins in cells that regulate cell growth. "These grants serve to highlight the importance of the partnership between Emory University, Georgia Tech and the Georgia Cancer Coalition," said Jonathan Simons, MD, director of Emory's Winship Cancer Institute. "This partnership, whi...Study describes basic mechanism in cell growth control involving damaged DNA
... cell uses protein degradation as one major way to regulate its own activity, to rid itself of proteins no longer needed, including the tumor suppressor protein p53," said Xiong. This protein stops the cell from growing or kills it, he added. "If the cell is growing happily, it would not want p53 around. So i...Rice engineer wins prestigious Annunzio Award
...ll adhesion, control synthesis of matrix proteins, regulate cell growth and promote the breakdown of the scaffold as new tissue grows around it. Using the latest techniques in genetics and biotechnology, West is designing improved signaling schemes to increase the growth rates of cells seeded onto scaffolds a...FSU scientist links iron imbalance to Parkinson's disease
...ive diseases, affect the molecular mechanisms that regulate gene expression." Levenson performed the mouse model portion of the study in collaboration with Mark Mattson, Laboratory of Neurosciences chief at the National Institute on Aging in Bethesda, Md. Mice were fed varying amounts of iron to de...Flies have morning and evening clocks
... next and, under natural light conditions, one can regulate the physiology of another," said Rosbash. The scientists theorize that this type of coupling between two circadian oscillators coordinates the two activity peaks and aids responses to environmental factors such as seasonal changes in lightness and da...Time-lapse movies show brain cells move like a two-stroke engine
...us to novel classes of cell surface receptors that regulate migration, and thereby the formation of cortical areas of the brain," says Hatten....Scientists identify new cause of obesity
...researchers showed is essential for the protein to regulate appetite. "These findings provide a whole new way of thinking about how hormone receptors could cause disease, and suggest different types of drugs for treating these diseases," said Bruce Conklin, MD, UCSF associate professor of medicine and also of...International human genome sequencing consortium describes finished human genome sequence
...r genes and the neighboring DNA sequences that may regulate their activity, dramatically cutting the effort and expense required to find regions of the human genome that may contain small and often rare variants involved in disease. "Finished" doesn't mean that the human genome sequence is perfect. There st...Are yeast cells bringing us a step closer in treating obesity?
...es), which then produces a reaction by the cell to regulate processes internal or external to the cell. A number of medicines play on this cellular operation to produce beneficial responses for our health. Now, for the first time, Katleen Lemaire and her colleagues, under the direction of Johan Thevelein of V...Early life stress harms mental function and immune system in later years
... can actually modify protein-DNA interactions that regulate gene expression," Meaney says. "The effects of mother-infant interaction on chromatin structure might define a basis for the development of stable individual differences in hormone function and behavior over the lifespan." ...Soaking up signal: Endocytosis controls spreading and effective signaling range of Fgf8 protein
...ers have reported evidence that cells can actively regulate the levels of secreted signaling proteins that they encounter in the context of their extracellular environment. The finding is important because cells in developing tissues are extremely sensitive to such protein signals, and thus the range of these...Yerkes researchers to present array of new data at Society for Neuroscience Meeting
...sporters, a recently discovered group of proteins, regulate activity of the basal ganglia, a region of the bra...nd environment can shape the brain mechanisms that regulate behavior. (11:30 a.m. 1 pm) Poster Presentations Dr. Smith and his research team: determined h...UCLA and Univ. of Utah researchers identify how a hormone regulates iron
...rs realized that if there isn't enough hepcidin to regulate ferroportin, too much iron is taken up from the digestive system into the body, which can lead to hemochromatosis, a major genetic disorder affecting about a million people in the United States. "For the first time we understand what happens in the d...Scientists closing in on nerve proteins' contributions to memory and hearing loss
...us system proteins interact in a manner that helps regulate the transmission of signals in the nervous system. Researchers report online in Nature Neuroscience that they've connected neuregulin-1 (Nrg-1), a protein linked to schizophrenia, and postsynaptic density protein-95 (PSD-95), a protein associated wit...Sleeping, waking, ... and glucose homeostasis
...isrupted. Two transcription factors (proteins that regulate gene expression) called Bmal1 and Clock regulate aspects of circadian rhythm, possibly by regulating neurons in the SCN. Other aspects of human phys...BU chemist to map DNA's surface, uncovering details that will show how structure abets function
...r regions, act individually and collaboratively to regulate protein-encoding genes. Other second-round grants went to researchers at the Genome Institute of Singapore; Intronn Inc., Gaithersburg, Md.; The Research Foundation of the State University of New York, Albany; The Salk Institute, La Jolla, Calif.; ...Molecular switch provides clues to remarkable adaptability of human pathogen
...tal Cell, provides new evidence about how bacteria regulate gene expression in response to changing environmental conditions to promote adaptation and long-term survival. Pseudomonas aeruginosa is frequently found in soil, water, plants, and animals and can thrive in a wide variety of environments. P. aerugi...