Research shows skeleton to be endocrine organ
... The discovery that our bones are responsible for regulating blood sugar in ways that were not known before com...ime that one hormone has a synergistic function in regulating insulin secretion and insulin sensitivity, and that this coordinating signal comes from the skeleton...New molecular regulators of hyperthyroidism and goiter
... transmitting TSH-induced signals and therefore in regulating thyroid gland function. This makes Gq and G11 potential new targets for the treatment of hyperthyroidism and goiter. In the study, Stefan Offermanns and colleagues from the University of Heidelberg, Germany, generated mice lacking the alpha-subunit...JCI table of contents: Aug. 9, 2007
... transmitting TSH-induced signals and therefore in regulating thyroid gland function. This makes Gq and G11 potential new targets for the treatment of hyperthyroidism and goiter. In the study, Stefan Offermanns and colleagues from the University of Heidelberg, Germany, generated mice lacking the alpha-subunit...Acute sleep deprivation leads to changes in nighttime urine production for men and women
...educed nighttime dip) lower levels of sodium regulating hormones (plasma rennin, angiotensin II and aldosterone) excessive excretion of osmoles (sodium and potassium). A change in the body's hemodynamics, caused by sleep deprivation, seems to account for these observations. ...Study finds gender differences in renal and other genes contributing to blood pressure
...ential contribution of genetic factors involved in regulating blood pressure based on samples drawn from a large...t 35 gene locations involved in two major pathways regulating blood pressure, kidney or adrenergic or regulation. The genotyping was confined to the top and botto...Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
...e identified two proteins that are responsible for regulating overlapping groups of genes during the development of red blood cells. The findings may point researchers to future gene therapies for patients with sickle cell anemia and beta-thalassemia. In an article pre-published online Aug. 3 as a First Ed...In a first, Einstein scientists discover the dynamics of transcription in living mammalian cells
...NA synthesis during elongation may be crucial for regulating gene expression. With this sort of mechanism, you could have everything at the ready in case you suddenly needed to rev up transcription, says Dr. Singer. Once the paused polymerase starts up again, in a very short time you could synthesize a new bat...JCI table of contents: August 1, 2007
...n the brain has been suggested to be important for regulating energy balance, but in which neurons its expression is important was not clear. To address this issue, Dominic Withers and colleagues from University College London, United Kingdom, generated mice lacking AMPK function in either POMC neurons or AgR...Particle emissions from laser printers might pose health concern
...ts are calling on government officials to consider regulating emission levels from laser printers. By all means, this is an important indoor source of pollution, Morawska said. There should be regulations. The health effects from inhaled ultrafine particles depend on particle composition, but the results can ...Prenatal stress keeps infants, toddlers up at night, study says
...in consolidating memory and facilitating learning, regulating metabolism and appetite, promoting good moods and sustaining both cardiovascular health and a vigorous immune function. Weve long known that childs sleep is vital to his or her growth, but the origins of problems affecting it remained unclear. Now,...MicroRNA works with Ago2 protein to regulate blood cell development
...ctivity of Ago2 would be the most efficient way of regulating microRNA function, OCarroll wanted to see whether it plays a role in the development of blood cells. In the bone marrow of adult mice where their blood stem cells reside OCarroll conditionally knocked out the gene that encodes Ago2. Two months la...Researchers watch antibiotics, bacteria meet at atomic level
... We think that this mobile loop is a hot spot for regulating transcription in all living organisms, not only by using antibiotics but also by manipulating cellular factors, she said....Prenatal alcohol exposure alters brain activity in the frontal-striatal areas
...he brain that results in significant problems with regulating behavior and optimal thinking and learning," she said....Effects of aging in stem cells
...me more active with age, while genes important for regulating gene expression and genomic integrity became less active. These results lend strong support to the notion that HSCs succumb to the wear and tear of aging, just like other cells, and shed light on the mechanisms of aging. To study HSCs regenerative...Scientists a step closer to understanding how anaesthetics work in the brain
...hat anaesthetics seemed to selectively enhance the regulating action of the potassium channel, preventing the neuron from firing at all meaning the neuron was effectively anaesthetised. The new research has identified a specific amino acid in the potassium channel which, when mutated, blocks anaesthetic act...A brain chemical that battles despair
... they sought to explore the role of ∆FosB in regulating adaptation to stress. Their approach involved first exposing mice to random shocks from which the animals could not escape. Such repeated exposure to inescapable stress tends to increase the lag time for mice to escape subsequent shocks, when they ar...The UAB heads a European research project on proteases and pathological processes
...eins that act as catalysts for other proteins when regulating many of the biological processes involved in blood coagulation, food processing, extracellular matrix renewing, etc. Without the regulation of protease activity, numerous pathologies can appear, such as cardiovascular, neuron and autoimmune diseases,...Metabolic syndrome -- don't blame the belly fat
...ed by the pancreas that plays an essential role in regulating the carbohydrates, lipids, and proteins obtained from food. The new study, published July 16, 2007, in the Proceedings of the National Academy of Sciences (PNAS), demonstrates that insulin resistance in skeletal muscle -- caused by decreased abil...JCI table of contents: July 12, 2007
...sity of Miami shed further light on the mechanisms regulating ER-alpha expression levels during breast cancer. In their study of 250 primary breast cancers, the authors found that ER mRNA levels overlap considerably between ER-alphapositive and ER-alphanegative breast cancers. This lack of correlation between......e believe that microRNA may also be significant in regulating other common chronic inflammatory diseases such as arthritis and certain autoimmune diseases, says Andor Pivarcsi, who has directed the study together with Enik Sonkoly. The study shows that microRNA has different patterns of expression in psoriasi...