Global heartbeat control suggests therapy for beating heart failure
...of the integrated processes that fuel the heart by regulating the expression of genes involved at each step. "The receptors control some 400 genes, and probably more," Gigure said. Rather than being randomly distributed, "the genes fell into precise categories of well-defined energy pathways." Further study o...Molecule that destroys bone also protects it, new research shows
.... "It turns out that IL-17 is really important in regulating neutrophils by causing other cells in the vicinity to recruit these infection fighters to the infection site," Gaffen said. IL-17 is a cytokine, a protein hormone made by "T helper" cells of the immune system that stimulate immunity. Gaffen noted th...Gladstone's Deepak Srivastava receives E. Mead Johnson Award for achievement in pediatrics
...ers. Specifically, he studies the molecular events regulating early and late developmental decisions that instruct progenitor cells to adopt a cardiac cell fate and subsequently fashion a functioning heart. Dr. Srivastava seeks ways to use these pathways to prevent congenital defects and treat acquired heart di...Regulating Californian stem cell research, and more
How is California regulating its $3 billion stem cell research initiative? Regulations governing human stem cell research must strive to assure strict oversight while simultaneously fostering scientific innovation through collaboration, says a group of scientists from the Cal...Nitric oxide: Key to cardiovascular and pulmonary function and drug effectiveness
...periments present a novel role for nitric oxide in regulating the activity of G-protein coupled receptors," Lefkowitz said. "Also, the findings point to the possibility that deficiencies in the activity of nitric oxide, which occurs in common disorders such as high blood pressure, diabetes, atherosclerosis, cys...Estrogen fluctuation affects epileptic seizures
...ibitory neurotransmitters, and that this occurs by regulating vesicles at inhibitory synapses (vesicles being the membranes that contain neurotransmitters). And once again, there was an additional, surprising finding, says Dr. Woolley. Estrogen receptors are typically found in the cell nucleus where they re...Reversing cancer cells to normal cells
... skin cell provide a previously unknown target for regulating tumor progression and metastasis. Dr. Hendrixs distinguished lecture is part of a session titled the cell microenvironment in development and cancer....Unicellular microRNA discovery
...ete differentiation, suggesting a possible role in regulating sexual reproduction. The discovery of miRNAs in a unicellular organism has evolutionary implications as well. While the existence of miRNAs in unicellular and multicellular organisms suggests that the miRNA pathway arose before these lineages split...The brain is more adept at using the nose than previously realized
...have looked at the how the olfactory bulb works in regulating smell and also examined behavior related to smell in mammals and other animals. "This is the first study to look at the ways in which mammals respond to challenges of distinguishing smells by studying actual activity in the olfactory bulb while vary...Researchers identify new genetic risk factors for type 2 diabetes
...-like growth factor 2 is thought to play a role in regulating insulin action. CDKAL1. This gene codes for a protein called CDK5 regulatory subunit associated protein1-like1. The protein may affect the activity of the cyclin dependent kinase 5 (CDK5) protein, which stimulates insulin production and may influ...U of M-led study identifies new genetic risk factors for type 2 diabetes
...-like growth factor 2 is thought to play a role in regulating insulin action. CDKAL1. This gene codes for a protein called CDK5 regulatory subunit associated protein1-like1. The protein may affect the activity of the cyclin dependent kinase 5 (CDK5) protein, which stimulates insulin production and may influen...MicroRNAs can be tumor suppressors
...ally only 20-25 nucleotides long and is related to regulating the expression of other genes. "Overexpression of the HMGA2 gene is an essential feature of many medically significant tumors, such as uterine fibroids, explains Dr. Dutta. It is very exciting to realize that microRNAs have an important role in sup...A relative of anti-aging gene Klotho also influences metabolic activity, obesity
... blood glucose in mice," he said. "Klothos role in regulating the metabolic activity of the growth hormones is essential." Dr. Kuro-o and his colleagues originally discovered the Klotho gene in 1997, naming it after one of the mythical Greek characters who controlled the length of human life. The Klotho pro...'Junk' DNA now looks like powerful regulator, Stanford researcher finds
...e first to suggest that transposons play a role in regulating nearby genes. In fact, Nobel laureate Barbara McClintock, PhD, who first discovered transposons, proposed in 1956 that they could help determine the timing for when nearby genes turn on and off....Highlighted sessions of ASBMB's 2007 Annual Meeting
...embrane receptor called alpha-2 beta-1 integrin in regulating the growth of cancer cells. Topic: Tuberculosis Session: Infectious Diseases in Minority Populations Tuberculosis Time/Location: 10:45 a.m.-11:30 a.m., Room 209C Title: "The Role of Resuscitation-Promoting Factors in the Virulence of Myc...News tips from the Journal of Biological Chemistry
...it has not been shown previously to be involved in regulating the replication of hepatitis C virus. Article: " p21-activated Kinase 1 Is Activated through the Mammalian Target of Rapamycin/p70 S6 Kinase Pathway and Regulates the Replication of Hepatitis C Virus in Human Hepatoma Cells " by Hisashi Ishida, Ku...How genetic malfunction causes a form of retardation
...led SHP-2. SHP-2 is involved in molecular pathways regulating development of brain cells. The NS mutations cause SHP-2 to be constantly activated. Specifically, SHP-2 plays a role in the pathways governing differentiation of immature precursor cells into neurons and glial cells. Unlike neurons, which conduct ...Genes and biomarkers that allow doctors to choose the right therapy for the right patient
...earchers have found 164 genes that are involved in regulating the sensitivity of squamous cell head and neck cancer cells to lapatinib, a cancer drug that was recently approved for use in metastatic breast cancer under the name Tykerb. The study, a collaboration with GlaxoSmithKline, evaluated 7,000 genetic ...Bioluminescence at the service of a novel cerebral imaging technique
...ns in the ellipsoid body, a structure involved in regulating locomotor activity. This structure is deeply embedded in the centre of the brain and has never been studied physiologically because it was always inaccessible to standard, fluorescent-type markers. Such recordings of the ellipsoid body have thus de...Other highlights from the April 18 Journal of the National Cancer Institute
...growth factor receptor family that plays a role in regulating cell growth. In about 15 to 20 percent of breast cancers, HER2 is overexpressed, and women with these kinds of tumors have a worse than average prognosis. Many breast cancers that express HER2 are resistant to the HER2 antibody trastuzumab, a drug of...