Research team identifies additional genetic risk factors for Crohn's disease
...me not associated with specific genes but possibly regulating the activity of other genes. Further understanding of how these variations contribute to the development of Crohn's should identify new targets for drug development, the authors write. ...3 proteins may play important role in nerve-cell repair
...lls called cAMP. This molecule plays a key role in regulating nerve-cell growth, differentiation and survival, a...these receptors are likely to play a major role in regulating cAMP production in nerve cells," says Saeki, an associate professor of neurological surgery and chie...Anti-wrinkle compound causes pathological reaction in skin cells
...ocked in cells or even in the liver. Yet, the laws regulating their use are far less restrictive than those regulating drugs," concludes Dr. Marceau....Scripps research study shows humans and plants share common regulatory pathway
...nce also suggests that the protein plays a role in regulating pathogen resistance in plants. Various genetic studies have identified SGT1 as a crucial component for pathogen resistance in plants through regulation of expression and activities of some R proteins Although there is a significant genetic crossove......ning cells and evening cells, keep circadian time, regulating what fruit flies do morning and evening, day in and day out. By genetically manipulating these groups of cells in this study, Stoleru and his colleagues discovered that the network is dominated by either one group, acting as the master clock, or t...Scripps research scientists identify new regulatory mechanism for critical protein signaling domain
...expected and striking," the study found that a new regulating messenger IP4, a small soluble molecule, augments ...s is something we stumbled into-the possibility of regulating the Ras pathway with IP4 at the level of DAG production through PLCg1," he said. "In the immature, d...JCI table of contents -- April 5, 2007
...ates that Gi proteins have many different roles in regulating airway constriction and dilation, leading the authors to suggest that “pharmacologic or genetic methods to modulate Gi [proteins] could have limited clinical utility.” TITLE: Crosstalk between Gi and Gq/Gs pathways in airway smooth muscle regulates...UCLA identifies new molecule involved in the body's processing of dietary fat
... that endothelial cells may play an active role in regulating the delivery of lipid nutrients to different tissues," Beigneux said. Experiments with cultured cells revealed that GPIHBP1 binds both chylomicrons and lipoprotein lipase, suggesting GPIHBP1 is a key platform for the processing of chylomicrons. ...Highlights from the April 2007 Journal of the American Dietetic Association
..., it is possible that women are better than men at regulating portion sizes of foods thatare more likely to increase body weight." Additional research articles in the April Journal of the American Dietetic Association include: "Influence of Intervention on Beverage Choices: Trends in the Dietary Interven...JCI table of contents: April 2, 2007
...angiotensin II in the SFO has an important role in regulating water intake, and therefore the amount of fluid in the body. As discussed in an accompanying commentary by Kelly Parsons and Thomas Coffman, these data suggest that RAS activity in the SFO and kidney are nonredundant and that "creative use of techniq...MIT's ocean model captures diversity of underwater forests
...' biological and chemical cycles and their role in regulating atmospheric carbon dioxide, an important greenhouse gas. The output of the new model, the brainchild of oceanographer Mick Follows, has been tested against real-world patterns of a particular species of phytoplankton, called prochlorococcus, which...Natural mechanism for immune suppression paves way for cancer trials
... he says. "What was not known was IDO activity was regulating the adaptive immune response."...Brain tissue reveals possible genetic trigger for schizophrenia
...s studies have shown that microRNAs play a role in regulating brain development. They also figure importantly in "synaptic plasticity," the ability of neurons to make connections with one another. "And those connections between neurons come and go all the time. It's a normal process for them to be pruned and g...Scientists identify a candidate gene for osteoporosis
... in BMD. To confirm the involvement of DARC in regulating BMD, Mohan's team characterized the skeletal phenotype of mice with and without the DARC gene. The DARC -knockout mice exhibited increased BMD and lower bone resorption compared to mice with the DARC gene, supporting the predicted role of DARC ...Fruit fly gene research may shed light on human disease processes
... as help in the chromosome-counting process and in regulating other crucial cell activities. "This signaling process is not unique to embryonic sex differentiation, but occurs in hundreds of genes throughout the body, in flies and in higher animals, too," Avila says. "Our work sheds light on signal transmiss...Tiny molecule controls stress-induced heart disease
...d a new and completely unanticipated mechanism for regulating the contractility of the heart," said Dr. Eric Olson, chairman of molecular biology and senior author of the study. "We're very excited about the therapeutic implications, but we still have much work left to do." Dr. Olson is director of the Nancy ...Cells use 'noise' to make cell-fate decisions
...ole interactions between distinct circuits play in regulating complex biological processes, such the differentiation of multipotent stem cells. Dr. Sel, who earned his doctorate in molecular biophysics from UT Southwestern, carried out much of the work for the Science paper while a postdoctoral research fel...JCI table of contents -- March 22, 2007
...S, which makes asparagine. However, the mechanisms regulating the susceptibility of ALL cells to asparaginase ar...rface protein known as ROMK1 (which is involved in regulating potassium uptake) by kidney cells, the molecular details behind this increased internalization have ...Making memories that last a lifetime
... the central nervous system as a "crucial step" in regulating gene activity involved in memory formation. What's more, they noted, abnormal epigenetic regulation has been seen in cancer, some types of autism, and schizophrenia. Thus, they said their findings could aid in basic understanding of epigenetic mech......chestrate the complex series of events involved in regulating cell fates and organ development in the embryo. Encouragingly, the researchers also found that giving supplemental cholesterol to zebrafish embryos exposed to alcohol restored normal development. Fetal alcohol syndrome is a term to describe an arra...