JCI table of contents -- March 8, 2006
...fragments in the blood that have a central role in regulating hemostasis, the physiologic process whereby bleedi...y therefore identifies a new function for SHIP1 in regulating platelet function to sustain normal hemostasis. TITLE: Deficiency of Src homology 2 domaincontaini...Triptolide: A potential drug for polycystic kidney disease
...mal kidney tubule cells have a built in switch for regulating their growth two proteins, PKD1 and PKD2, located on a bristle-like cilium that bends in response to fluid flow across the cell. During kidney development, cells destined to line a kidney tubule grow and divide until the tubule is formed, as sensed...Sphingolipids with therapeutic ends
...undamental to the architecture of the cell and for regulating metabolism. They are important regulators of certain biological functions. Biological functions as important as the regulation of cellular proliferation, i.e. cell growth. And not just growth, but also the death of the cells. Often cells die due to a...Carnegie Mellon researchers urge regulators to rethink strategies for soot emission
... officials need to adopt new ways of measuring and regulating the fine particles of smoke and soot so endemic to...ic policy. "We need to take a holistic approach to regulating these sources that account for all emissions." Accounting for these new processes improves the predi...UC Davis researchers discover key to body's ability to detect subtle temperature changes
...of cells. They have the ability to open and close, regulating the flow of charged ions and controlling the voltage gradient found between the inside and outside of every living cell. In the current study, Zheng and his colleagues focused on a group of ion channels called transient receptor potential (TRP) ch...Killing the messenger RNA -- But which one?
...hey are being seen as vitally important players in regulating the genome. Now, a new study led by researchers at The Wistar Institute shows that these microRNAs can undergo a kind of molecular editing with significant physiological consequences. A single substitution in their sequence can redirect these micro...... in his laboratory shows that TCTP plays a role in regulating Rheb (Ras homologue enriched in brain), a protein ...nd biochemically that TCTP is directly involved in regulating Rheb function so that it regulates cell size as well as cell numbers. We found that in the case of d...Fetal heart-cell enzyme important in onset of heart failure
...also found that HDAC works in the heart in part by regulating expression of another enzyme called Inpp5f, which ...ancer. "HDAC and Inpp5f give us new targets for regulating cardiac hypertrophy," says Epstein. "Inhibitors of HDAC may warrant testing for cardiac disease to s...ALTRAN: Industry experts address technology challenges at Altran Innovation Conference
...a 3kg payload and a device capable of autonomously regulating diabetes. Unveiled at the conference was the winner of the Ecobuilding Forum of 8 9 November 2006. This concept, a type of communal organic recycling centre, is solar powered, gathers rain water, harvest methane (in turn used to power the square's l...Breakthrough in understanding type 2 diabetes as key genes identified
...transporter known as SLC30A8, which is involved in regulating insulin secretion. Type-2 diabetes is associated with a deficiency in insulin and the researchers believe it may be possible to treat it by fixing this transporter. Professor Philippe Froguel, one of the authors of the study from the Division of ...Smithsonian receives $8M HSBC grant
...st ever field experiment on the role of forests in regulating the quality and quantity of water flow in the Panama Canal, the most important watershed for world commerce "HSBC's grant will bring science to a new level by enabling us to document quantitatively some of the environmental services that tropical fo...Columbia scientists determine 3-dimensional structure of cell's 'fuel gauge'
...h diabetes, including problems that diabetics have regulating blood sugar. Dr. Shapiro explained that researchers do not yet know how to activate AMPK without activating other proteins and causing potentially toxic side effects. However, he notes that this development in understanding the atomic resolution s...Good for the goose, not so great for the gander
... this might occur. Mitochondria play a key role in regulating the programmed cell death pathway, or apoptosis. I...rol sex determination and be very much involved in regulating human life span, he said. His team aims to find out how manipulating the activity of the analogou...Taking heart failure to the MAT1
...sential partner to PGC-1, facilitating its role in regulating cell metabolism. In fact, two forms of PGC-1 exist alpha and beta both of which have been reported by other groups to be vital to the heart. Both forms of PGC-1 were shown by Schneider's team to depend highly on MAT1 and to turn on the ordinarily......ated which parts of the cerebellum are involved in regulating the activity of a single muscle. Furthermore, they examined the consequences of inactivation of one or more parts of the cerebellum on the functioning of this muscle. Nerve cells in the cerebellum receive two types of signals. Through the climbing...Virginia Tech's System X supercomputer provides super tool for simulation of cell division
...anted to characterize all the protein interactions regulating the cell cycle of budding yeast (the yeast cells familiar to bakers and brewers, and a favorite organism of molecular biologists, as well). "Such fundamental research on the cell cycle of budding yeast provides a basis for understanding the reproduct...Joslin-led study uncovers role of appetite hormone MCH in insulin production
...research process is to pinpoint exactly how MCH is regulating the growth of beta cells and identify which proteins are involved in this growth process. We know MCH is having an effect on both growth and function likely by recruiting different proteins. It will be worth exploring which proteins are being activat...'Quiet revolution' may herald new RNA therapeutics
...hat one particular type of RNA plays a key role in regulating the gene implicated in control of tumour growth. The research is published online today in Nature. The Human Genome Project identified about 34,000 genes responsible for producing proteins. The remaining part in fact, most of the genome constitut...Tracing the pathways of neurofibromatosis
... box O,' or FOXO. FOXO proteins are key players in regulating the genes responsible for programmed cell death and DNA repair two common culprits in cancer. "Our results raise the possibility that neurofibroma formation in individuals with neurofibromatosis might result in part from a Ras-PI3K-Akt-dependent i......ates in thebloodstream and plays a crucial role in regulating wound healing. SAP's roleis to inhibit the activity of immune cells called fibrocytes, which makeexcess collagen that the body uses to heal wounds. Gomer said the tests atRice show that maintaining an elevated level of SAP in the blood is enoughto pr...