Jefferson scientists explain cancer cell metabolism changes
...between the mitochondria and the nucleus one gene regulating both compartments of the cell. We didn't know what coordinated both functions. This shows both are functionally linked by a common gene." "If we have therapies that target changes in metabolism, it allows us to develop therapies selective for the c...An irregular heartbeat makes exercise deadly
...lthough CASQ2 is thought to have a crucial role in regulating contraction of the heart, individuals lacking both copies of CASQ2 and whose hearts contract relatively normally have been identified. In a study that appears online on August 24 in advance of publication in the September print issue of the Journal o...JCI table of contents: August 24, 2006
...lthough CASQ2 is thought to have a crucial role in regulating contraction of the heart, individuals lacking both copies of CASQ2 and whose hearts contract relatively normally have been identified. In a study that appears online on August 24 in advance of publication in the September print issue of the Journal o...Loss of just one species makes big difference in freshwater ecosystem, study finds
..., and because of this, it plays a critical role in regulating the breakdown and transport of carbon in the rivers. "This fish species is a popular food source; it is harvested regularly, and in some cases, it's overfished," says Taylor, the lead author on the study that was published in the August 11 issue o...JCI table of contents: August 17, 2006
...ls and might provide new therapeutic approaches to regulating aldosterone production. TITLE: Molecular basis for the modulation of native T-type Ca2+ channels in vivo by Ca2+/calmodulin-dependent protein kinase II AUTHOR CONTACT: Paula Q. Barrett University of Virginia School of Medicine Charlottesville, V...Be still my beating heart: Ilk gene underlies heart failure
... G&D reveal a critical role for the ILK protein in regulating cardiac contractility identifying a new genetic component of heart disease. Congestive heart failure affects 2-3 million people in the United States annually. A large portion of congestive heart failure cases is caused by a condition known as card...Brain's cannabinoid system 'mellows' seizures
...ds that trigger them, as well as the machinery for regulating the process--was already known to modulate the excitation of neuronal transmission, noted the researchers. However, it had not been established that such modulation might affect neurons in the hippocampus responsible for the "excitotoxicity" that und...Researchers identify human DNA on the fast track
...tend to be located near genes that are involved in regulating the function of genes. Furthermore, 12 of the regions are adjacent to genes involved in the development of the brain. The Nature paper looks in depth at the region that has undergone the most change in the human lineage, which the researchers called...How secondhand smoke injures babies' lungs
...th, apoptosis went awry. Critical cellularcontrols regulating cell death turned off. Alveolar cells died twiceas fast as they should have. "If you are killing cells at a higher rate during a criticaldevelopmental stage, when they are supposed to be proliferating inorder to create new alveoli, the lungs may ne...ACS News Service Weekly PressPac -- August 9, 2006
...ates and Europe have taken different approaches to regulating acrylamide levels in food. The highest levels occur in French fries and potato chips. Efforts to reduce acrylamide in food in the United States may depend on the fate of a proposed Federal law, according to the C&EN article. The law would restrict st...Expression of 'Blimp1' gene leads to the discovery of cells responsible for skin's sebaceous gland
...is somehow controlling this progenitor population, regulating how many cells are allowed into the gland. This is the first molecular characterization of these cells." "This study has implications for understanding sebaceous gland disorders ranging from acne to sebaceous cell cancers," says Fuchs. "And it not on...JCI table of contents: August 1, 2006
...?id=29441 IMMUNOLOGY A designer approach to regulating autoimmunity in diabetes Type 1 diabetes is an...TLE: Costimulation couture: a designer approach to regulating immunity AUTHOR CONTACT: Mohamed H. Sayegh Harvard Medical School, Boston, Massachusetts, USA. Pho...Study pinpoints how genetic glitch could keep some people from feeling full
...r, a gene found in brain cells that play a role in regulating hunger, are the most common cause of genetic obesity. Now University of Florida researchers have determined how some of these mutations cause the receptor to miss signals from molecules that tell the body when to eat and when to put down the fork, pl...Improving livestock health, trade and human livelihoods in Africa
...establish central government units responsible for regulating CAHW activities. Their work also prompted the global body responsible for animal health the Office International des Epizooties to revise its guidelines to include CAHWs as one type of veterinary para-professional. The paper calls for the "AU's ...'Friend' protein keeps nerve signals in check
...his friendly protein appears to play a key role in regulating the synaptic release of neurotransmitter chemicals...that become competent to fuse at synapses, thereby regulating the amount of neurotransmitter released. "If you remove tomosyn, you get exuberant neurotransmitte...Study identifies new role for breast cancer susceptibility gene
.... BRCA1 is known to serve as a tumor suppressor by regulating DNA damage repair and maintaining genomic stabilit...uppression beyond maintaining genomic stability by regulating intercellular signaling within the tissue microenvironment. This view will extend BRCA1's tumor supp...Researchers find cause of frontotemporal dementia
...mong other things, the frontal lobe is involved in regulating behavior, movement and mood, and is responsible for cognitive functions like memory and speech. So, FTD is clinically characterized by changes in personality and, in a later stage, loss of cognitive functions. Looking for the needle in the haysta...UF study sheds light on cystic fibrosis-related diabetes
...s of the chemotherapy drug and had more difficulty regulating blood sugar levels, both while fasting and after receiving glucose. Mice that were still able to produce the crucial protein that prevents cystic fibrosis were able to maintain normal blood sugar levels, even after the drug had damaged some of their ...Mutation in tumor suppressor gene causes pancreatic islet cells to reproduce
... better we understood the precise role of menin in regulating islet cell proliferation. This latest finding about the acute and specific role of menin on repressing islet cells, but not adjacent exocrine cells, led to the realization that manipulating the menin pathway might be a powerful way to stimulate islet...... DBP, TEF, and HLF--mediate rhythmic physiology by regulating the activity of still other genes. Earlier studies by Schibler's group found that mice lacking one or two of the PAR bZip proteins exhibit only mild symptoms. Half of those animals lacking all three genes, however, died as a result of epileptic sei...