Stanford cooling tool may improve performance of athletes, soldiers
... such tremors occur because the body's temperature regulation mechanisms are suppressed during anesthesia. They reasoned that rapid rewarming might stop the tremors sooner. It turns out they were right. "We used a pressure differential to draw blood to the skin surface, then we applied heat to the skin to ...Dying cells encourage neighbors to grow
...rrounding tissues. They also suggest that abnormal regulation of apoptosis, as has been shown to be the case in some cancers, may result in pathological activation of these pathways. "Based on the behavior of undead cells in Drosophila imaginal discs, one might expect mutations that block or delay apoptosis to ...New genetic tools provide clues to the effects of exercise and diet on obesity, diabetes
...t adenylate kinase 1 (AK1), an important enzyme in regulation of cellular energy metabolism, particularly skeletal muscle, was highly expressed in obese and morbidly obese women relative to lean control subjects. Total muscle AK1 activity also increased 1.9-fold in obese and 2-fold in morbidly obese women. "Sur...U-M scientists see ubiquitin-modified proteins in living cells
... of Jun builds up in the cell, which can alter the regulation of gene transcription and cell growth. "Applying ubiquitin-mediated fluorescence technology to Jun made it possible to discover new information on how Jun turnover is controlled in cells," Kerppola says. The technology uses comple...Yale scientists find cooperative RNA switches in nature
...ia that operates as a rare "ON" switch for genetic regulation of the three proteins in a glycine processing system. "This seems like something only a biochemist can appreciate, but what it really means is that modern RNA has what it takes to run the complex metabolism of life. It is like what would have been ne...Society for Psychophysiology Research
...W. Pennebaker, University of Texas, Austin Emotion regulation research typically focuses on emotional responses ...st for weeks or even months. What, if any, emotion regulation strategies can work for extended periods of time? A series of studies will be presented that suggest...'Junk' DNA may be very valuable to embryos
...ht to be non-functional, may play some role in the regulation of gene expression and promotion of genetic diversity. Dr. Barbara B. Knowles and colleagues from The Jackson Laboratory in Bar Harbor, Maine, found that distinct retrotransposon types are unexpectedly active in mouse eggs, and others are activated ...New method identifies chromosome changes in malignant cells
...science and statistics to questions concerning the regulation and function of genes. In September, Technology Review magazine, which is published by the Massachusetts Institute of Technology, announced that it included Troyanskaya in its annual list of 100 top innovators from around the world. The magazine cite...Intracellular protein localization involved in new tumor progression pathway
...rstanding the molecular mechanisms involved in the regulation of apoptosis is key for developing proper cancer t... the cellular location is directly involved in the regulation of apoptosis and the establishment and progression of tumors. The authors identified a specific mito......t are normally controlled by TR4 and contribute to regulation of specific behaviors," she adds. Scientists have known that the receptor is present throughout tissues such as muscle, spleen, thyroid gland, the testes, and the cerebellum, but they didn't expect that knocking out the receptor would have suc...Manipulation of epigenome turns off as many genes as it turns on
...hey compared these methyl-based mechanisms of gene regulation to a chromosome-based one, also in early clinical trials, using a chemical called trichostatin A, or TSA, that gently unravels the chromosomes, exposing genes and allowing their instructions to be read. Much to the team's surprise, both chemic...Early life stress harms mental function and immune system in later years
...s on the developing central nervous system and its regulation of basic physiology, psychology, and immune function. Several reports at this meeting demonstrate that this phenomenon is conserved across species-from the barn owl to rodents to humans-suggesting that these effects are mediated by fundamental mechan...Wistar study demonstrates heritability of non-genomic information
... inherit epigenetic information to ensure that the regulation of our genes is executed correctly," says Jumin Zh... an assistant professor in the gene expression and regulation program at Wistar and senior author on the new study. In their experiments with fruit flies, Zhou an...UGA scientist Moran receives $2.6 million from Gordon and Betty Moore Foundation for marine research
... a key feedback loop in theories of global climate regulation for which biotic processes are central elements. The Gordon and Betty Moore Foundation launched its 10-year Marine Microbiology initiative last April with the goal of attaining new knowledge regarding the composition, function and ecological role of ...Sleeping, waking, ... and glucose homeostasis
...ned within fairly narrow limits for survival. This regulation is controlled in part by a balance between blood s...the effect of the molecular clock genes in glucose regulation (homeostasis) by examining mice in which Clock and Bmal1 were impaired. In normal mice they observed...First human trial of bioartificial kidney shows promise for acute renal failure
...ic waste products, and cannot provide the cytokine regulation function of living cells. Traditional therapy for patients with acute or chronic renal failure involves dialysis or kidney transplant, both of which have limitations. Humes and his colleagues began developing this technology a decade ago, identifying...Initial sensor for p53 tumor-suppressing pathway identified
....S., Ph.D., a professor in the gene expression and regulation program at The Wistar Institute and senior author on the Nature study. "Now, we know it is the initial sensor for the p53 tumor-suppressor pathway - it is responsible for detecting DNA breaks - and we also have a good idea how it works." According to...U-M researcher examines the cell's housekeeping habits
...organisms, including mice, and can tinker with the regulation of the process to see how it works. Cancer researchers have been trying to figure out how to turn apoptosis on as a way to have cancer cells kill themselves. Being able to control autophagy may prove useful as well, Klionsky said. In fact, any kind...Asymmetric organs and microRNA-directed DNA modification
...ember issue of Developmental Cell reveals that the regulation of critical genes that guide development of asymmetric leaf patterning depends on microRNA-directed gene inhibition via DNA methylation. MicroRNAs are a class of very small genes that do not code for proteins but instead act as regulators that can i...... recognize the origin of eggs is important for the regulation of worker reproduction in primitively eusocial stage rather than self constraint. Contact: Dr Koji Tsuchida, Laboratory of Entomology, Gifu University, Yanagido 1-1, GIFU, 501 1193, Japan Proceedings of The Royal Society B: Biological Sciences Model...