Yale scientists find microRNA regulates Ras cancer gene
...s contains sequences encoding microRNAs, important regulators of development, that control processes determining cell type and cell death. "The let-7 microRNA regulates Ras by binding to the message for Ras and likely inhibits translation of the Ras protein," said Slack. "The microRNA does not revert a mutated...A regulatory network analysis of phenotypic plasticity in yeast
...others. Promislow has now discovered that the more regulators a gene has, the more plastic the gene. Furthermore, he shows that the plasticity of a gene depends on its function. From these simple patterns, we gain insight into the complex genetic architecture that determines how well an organism can respond to ...Protein tags regulate key ion channel
...dium and calcium to flow in and out and so are key regulators of many fundamental processes in biology. "Ions are the currency of the cellular world," explained Goldstein. "Cells collect some ions, others they discharge. Ions are stored, spent, and exchanged." "Cellular solvency," he added, "the ability to res...Experts on iron-sulfur proteins to meet in Madison, Wisconsin
...uster proteins also play critical sensing roles as regulators of gene expression." Despite the importance of Fe-S proteins, the mechanism by which the Fe-S clusters are synthesized and inserted into proteins is poorly understood. However, this is changing. In the last several years proteins have been discovered...Water research initiatives at UW-Madison
... coalition of farmers, environmental groups, state regulators and scientists that comprise the "Wisconsin Buffer Initiative" is closing in on solutions to the contentious issue of riparian buffer zones on state waterways. Buffers are strips of vegetation near rivers and streams that help remove sediment and pol...Stem cells and regeneration: Opening up a new can of worms
...putations. As a result of these studies, candidate regulators of stem cells and directors of sequential steps of regeneration were identified along with genes that appeared to be critical for normal physiological processes. "Our study demonstrates the great potential of RNAi for the systematic exploration of ge...Fundamental genes regulate human blood stem cells
...e. The researchers conclude that HES-1 and HLF are regulators of HSC behavior. Because HES-1 and HLF impact HSC function via two different mechanisms involving integral pathways common to all human cells, the authors suggest that HSC behavior may be controlled by general rather than HSC-specific genes. "Our rep...Unexpected lock and key mechanism found for the assembly of tumor blood vessels
... receptor-ligand pair previously identified as key regulators of immune cell function puts the finishing touches on newly constructed blood vessels by allowing the two cell layers of blood vessels to recognize and "lock" together. The study, which appears in the June 2005 issue of the Journal of Clinical Invest...University of Minnesota to host international whole grains conference
...le grain researchers, manufacturers, educators and regulators from around the globe as they meet May 18-20 in the Radisson Plaza Hotel, Minneapolis, to develop a research agenda and action plan for including more whole grains in peoples' diets. Hosted by the University of Minnesota, "Whole Grains & Health: A Gl...Excess liver gene protects against high-fat diet
...bolic genes. "Liver X receptors had emerged as key regulators of cholesterol and lipid metabolism," said Lazar. "The current study elucidates a previously unrecognized role for these liver receptors in the links between diet, serum lipids, and atherosclerosis." Selective modulation of the LXR target genes in li...B cells are required for development of epithelial cancer associated with chronic inflammation
... Cancer Cell identifies B lymphocytes as important regulators of premalignancy associated with chronic inflammation. The results suggest that drugs targeted against B lymphocytes or recruitment of innate immune cells toward premalignant tissue may represent a viable strategy to protect against the development o...2005 Elizabeth Fleming Stier Award: George J. Flick Jr.
...gram has provided funds to industry, academia, and regulators to address problems affecting the seafood industry. His School Food Service Conference, which he formed in the early 1970s as a result of changes to the school lunch program, provided instructions to school foodservice managers on how to comply with...Study establishes new class of cancer-causing genes
...ntists have discovered that a new class of genetic regulators called "microRNAs" influences normal human growth and development. Now, researchers have found that microRNAs also play an important role in human cancer. The findings are published in tomorrow's issue of the journal Nature (June 9). "These studies c...New regulators of apoptosis and chemoresistance identified
...rs of the AGC family of kinases, and several novel regulators of apoptosis and chemoresistance. "Interestingly,...cognized general role for phosphatases as negative regulators of apoptosis. This is important because phosphatases cannot be simply viewed as enzymes that oppose ...Cancer related gene p53 not regulated as indicated by previous tissue culture research
... new study focuses our attention on the network of regulators of p53 and how they are regulated." "This study c...t not be so important as modifications of negative regulators and co-activators." Many chemotherapeutical drugs used to treat cancer exert their biological effe...JCI table of contents July 1, 2005
...ty establish the role of LXR alpha and LXR beta as regulators of renin. The data provide information for the development of novel selective modulators of LXR alpha and beta for several disorders including hypertension and heart failure. TITLE: Liver X Receptors alpha and beta regulate renin expression in viv...Brain size may depend upon how neural cells are cleaved
...rotrimeric G proteins were very good candidates as regulators of the plane of cell division in neural precursors... known as AGS3 and mPins in mammals -- as upstream regulators of G proteins. The researchers' analyses showed that AGS3 is, indeed, expressed in progenitor cells...Mechanism proposed for link between RU-486 and fatal infections
...glucocorticoid effects may interfere with chemical regulators known as cytokines, offsetting the delicate balance between over- and under-activation of the immune system. This disruption impairs the body's ability to fight off C. sordellii and may help spread the bacteria's toxic by-products, a combination that...... the motor proteins to work together. "They act as regulators of this subtle coordination," Scholey said.......een in cultured Drosophila cells to identify novel regulators of the JAK/STAT signaling pathway. In a stunning example of the utility of cell-based RNAi analysis in a genetically tractable system, like fruit flies, the researchers identified 121 genes involved in the JAK/STAT pathway, including a key, and previ...