Tag: "regulatory" at biology news
Unravelling new complexity in the genome
... Barash has uncovered what appears to be part of a regulatory
code that controls alternative splicing patterns i...ne regulation. The number of genes and coordinated regulatory
events involved in specifying cell and tissue type characteristics appear to be considerably more ex...
Gene regulation, not just genes, is what sets humans apart
...rnal Nature Genetics. His group looked at the regulatory
sequences immediately adjacent to 6,280 genes on t...hat has 88 percent the same genes as humans. These regulatory
stretches of DNA are where proteins bind to the genome to initiate a genes function. And it is here ...
Evolution is driven by gene regulation
...n difficult because the nucleotide sequence of DNA regulatory
regions, or promoters, are more variable than the ... comparisons. While many molecules that bind DNA regulatory
regions have been identified as transcription factors mediating gene regulation, we have now shown t...
JCI table of contents: Aug. 9, 2007
...specific portion of the DNA (known as the upstream regulatory
element; URE) that controls the level of expression of the PU.1 gene develop acute myeloid leukemia (AML). When researchers from Harvard Medical School, Boston, analyzed the equivalent URE in humans they found that a subset of individuals with AML ha...
Penn researchers discover how key protein stops inflammation
...vania School of Medicine recently identified how a regulatory
protein called Bcl-3 helps to control the bodys in...lammation. By using what we now know about Bcl-3 regulatory
function, we hope to create new ways to control inflammation for therapeutic purposes with selective...
Forsyth scientists gain new understanding of adult stem cell regulation
... system to molecularly dissect conserved stem cell regulatory
mechanisms in vivo. Planarians have powerful regeneration capability that makes them ideal for studying this process. The Forsyth team uses planarians and other animal models to study development and regeneration. The Forsyth team will publish this...
Research teams uncover risk genes for multiple sclerosis
...elieve that this receptor and its interaction with regulatory
T cells will now become a major focus of research on MS. The NEJM paper involved a hypothesis-neutral approach, in which the research teams scanned the entire genome of MS patients, their families and a control group for similarities and differenc...
Risk genes for multiple sclerosis uncovered
...rol the activity of a class of immune cells called regulatory
T cells. Two papers appearing simultaneously in Na...elieve that this receptor and its interaction with regulatory
T cells will now become a major focus of research on MS, says Stephen Hauser, professor of neurology...
Report recommends off-site disposal of secondary waste
...ition to secondary wastes, the report examines the regulatory
requirements associated with trial burns at the incinerator facilities. Trial burns are used to ensure that 99.9999 percent of the toxic agents will be destroyed during regular operations. The time required to complete a trial burn, submit results,...
FDA Nanotechnology Task Force takes positive step forward
...he agencys effort to tackle the new scientific and regulatory
challenges posed by nanotechnology. The Task Fo...to a transparent public process for developing its regulatory
policies. Public participation will be key both to developing good policies and winning public confi...
FDA sees nanotech challenges in every product category it regulates
...ations Nanotechnology Task Force about the agencys regulatory
approach toward nanotechnologyan exciting new fiel...nt risk research. It is critical that FDAand other regulatory
agencieshave the means necessary to evaluate which nanomaterials are harmful and which are not. This...
Study identifies new gene therapy tools for inherited blindness
... In addition to further studies of the grammar of regulatory
sites active in photoreceptor cells, Corbo and others are currently using the results of the study to design gene therapy vectors for a form of Leber's congenital amaurosis, an inherited disorder that leaves patients blind from birth....
Call for EU to launch major project to map out all our proteins
... many pathogenic infections, involve disruption to regulatory
processes in cells or tissues with associated changes in the abundance of proteins and their interactions, Aebersold pointed out. The idea would be that if we could map out the whole proteome, we could develop a toolbox structure enabling assays (for...
Contributing membership in the biomarkers consortium surges to 30 companies and nonprofits
...ual value, and formalize their use in research and regulatory
approval. The overall aim of The Biomarkers Consortium is to accelerate delivery of technologies, medicines, and therapies for successful prevention, early detection, diagnosis, and treatment of disease. The identification of biomarkers is an esse...
Awards celebrating women and biotech brilliance
...nology, but alsoendeavours to showcase the growth, regulatory
issues and opportunities in clinical trials in Queensland.Together with this, QCTN remains steadfast in highlighting its members and their affiliates and the importanceof clinical trials industry related careers in Queensland and the difficulties inv...
A new report, 'Where Does the Nano Go? End-of-Life Regulation of Nanotechnologies'
...f and treated at the end of their use, and how the regulatory
system will treat such materials at the various stages of their lifecycle. A new report from the Project on Emerging Nanotechnologies, Where Does the Nano Go" End-of-Life Regulation of Nanotechnologies, addresses these issues. Authored by Linda K. ...
A brain chemical that battles despair
...brain. This protein is a "transcription factor," a regulatory
protein that controls the activity of multiple target genes. In the new experiments, they sought to explore the role of ∆FosB in regulating adaptation to stress. Their approach involved first exposing mice to random shocks from which the anim...
Fedoroff, of Penn State, to receive National Medal of Science
...overed a unique type of heritable, but reversible, regulatory
circuit -- now called epigenetic -- that controls the mobility of transposons. After moving to Penn State in 1995 as the Willaman Professor of the Life Sciences, she founded and directed a multidisciplinary organization now known as the Huck Instit...
EPA foregoes opportunity to improve nanotechnology oversight
... controls and to give a predictable nanotechnology regulatory
environment for industry and consumers, he continu...to get these answers" Not enough. Can the existing regulatory
system protect the public from potential problems with nanotechnology" Not adequately. It is time fo...
One man's junk may be a genomic treasure
...ches of DNA within the genome that contain all the regulatory
signals and other information necessary to activate or repress a particular gene. Each domain is an entity unto itself that is defined, or bracketed, by a boundary, much as words in a sentence are bracketed by punctuation marks. The researchers dat...
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