Epigenetic studies will provide a better understanding of disease
...regulate gene expression. This additional layer of regulatory instructions, which are not held in DNA, comprise the epigenetic code. Epigenetic differences explain, for example, why two cloned organisms are not the same or why twins develop illnesses of distinct genetic origin. Epigenetic studies promise not ...Researchers use poliovirus to destroy neuroblastoma tumors in mice
...genome called a "spacer region", with an essential regulatory gene removed from elsewhere in the viral genome. ...," said Cello. "And in the unlikely event that the regulatory gene element is deleted, the virus would not be able to reproduce." To test the virus' ability to ...Nanotechnology oversight requires thinking outside the box
...'s Project on Emerging Nanotechnologies, "existing regulatory approaches likely will prove to be suboptimal. Novel problems require novel solutions, and the oversight of nanotechnology will require 'out of the box' thinking. As an alternative, this report suggests that a number of statute-independent questions ...New drugs for cancer therapy at international conference in Amsterdam
...b. All of these have been approved or are awaiting regulatory approval in various cancer indications. In addition, a range of agents in earlier phases of development will be discussed. The TAT 2007 program incorporates presentations of results from early-phase clinical trials (phase I and phase II) that have no...... with viral proteins. Interactions involving viral regulatory factors have a direct impact on the amount of virus produced by the HIV host cell", Brack-Werner explains. "Preventing HIV proteins from interacting with their crucial partners is a promising approach to developing novel therapies." Therefore the GSF...Thinking big about things small
...DA) is evaluating the effectiveness of the agencys regulatory approaches and authorities to meet the potential unique challenges presented by the use of nanomaterials in FDA-regulated products, and the agency expects to issue its findings in July 2007. A new report by former EPA official Mark Greenwood, Think...New report: Explosive growth changes salmon industry
...nd. The report also recommends: harmonizing regulatory food safety standards; recognizing and mitigating environmental impacts of both farmed and wild salmon production; providing accurate and balanced information about salmon issues; collecting better data about seafood markets and consumers...Ovarian cancer may mimic fallopian tube formation
...are a lot of decisions that have to be made by the regulatory genes, like pax8, before the end products can be made. Bowen's next steps are to find out why paired box gene 8 gets turned on and to discover its targets in order to find out of it turns on another decision-making gene or an endpoint gene. "That...Penn researchers discover new molecular path to fight autoimmune diseases
...en one type of white blood cell, called the immune regulatory cell, malfunctions. In humans, one cause of this m... that act on the FOXP3 protein, in turn making the regulatory immune cells work better. These findings have important implications for treating autoimmune-related...Fruit flies may pave way to new treatments for age-related heart disease
...aging," he said. "We need to better understand the regulatory systems that control the level and activity of known cardiac channels and other unknown factors involved in coordinated heart muscle contraction." In fact, the researchers are now looking at identifying other genes that regulate KCNQ channel functi...Targeting the adrenal gland could be key strategy against heart failure, Jefferson scientists show
...and norepinephrine. By blocking GRK2, an important regulatory enzyme, they cut the hormone production that forces the heart to pump too hard, leading to heart failure. Such a novel approach targeting the adrenal gland in addition to the heart provides a potential new strategy against heart failure, and could ...'Ten Commandments' could improve fisheries management
...the context of existing knowledge, approaches, and regulatory mechanisms. "As much as anything, the real challenge here is changing our world view," Hixon said. "We must accept the need for change in how we approach fishery science and management. There are still many people who think we can accomplish our goa...The last wild hunt -- Deep-sea fisheries scrape bottom of the sea
...nternational waters) far from the watchful eyes of regulatory agencies its impacts on species and ecosystems is generally neither monitored nor controlled. "The unregulated catches by these roving bandits are utterly unsustainable," says Robert Steneck, of the University of Maine. "With globalized markets, t...Researchers publish first working model that explains how biological clocks work
... for understanding biochemical signaling and other regulatory processes in cells, said Arnold. Before this res...rom the interaction of even a small number of gene regulatory elements," said Arnold....New mechanism for nutrient uptake discovered
...pid shut-off. They think it might be a very common regulatory event called phosphorylation, where a phosphate molecule is introduced to another molecule, changing the latter, and preparing it for a chemical reaction. They have found a site for phosphorylation and are looking at this possibility further. A le...The code of codes -- Scientists discover parallel codes in genes
...such as splice sites, mRNA secondary structure, or regulatory signals. Itzkovitz and Alon also demonstrated th... and function of the genome. Many currently known regulatory sequences reside in non-protein-coding regions, but this may give scientists incentive to delve deep......contain the code for protein, or by disrupting the regulatory regions of the genome that control gene activity - the on/off and dimmer switches in our genome. "Although the simplest model for a CNV affecting gene activity is where the variant is a deletion of a gene or part of a gene, we found examples where ...JCI table of contents -- February 8, 2006
...oencephalitis. TITLE: Role of a CUF1/CTR4 copper regulatory axis in the virulence of Cryptococcus neoformans AUTHOR CONTACT: Peter R. Williamson University of Illinois at Chicago, Chicago, Illinois, USA. Phone: (312) 996-6070; Fax: (312) 413-1657; E-mail: prw@uic.edu . Sherri McGinnis Gonzlez Office of P...Researchers discover master metabolism regulator with profound effect on fat metabolism
...acids in the diet. They also discovered that this regulatory substance, an enzyme named GCN2 eIF2alpha kinase, ...ts in the body. These findings about the crucial regulatory role of GCN2 kinase in the metabolism have major implications for the treatment or prevention of obe...Beyond the DNA: Chemical signatures reveal genetic switches in the genome
... identified hundreds of novel genomic regions with regulatory potential." Moreover, says Heintzman, this 'histone code' was able to accurately distinguish between promoters, from which gene transcription is directly initiated, and enhancer regions - some of which are very distant from the target gene - to which...