JCI table of contents: Feb. 1, 2007
...re shown, by two independent mechanisms, to bind a regulatory region of DNA in the gene encoding FSP1. This regulatory region of DNA is known as FTS-1 and the binding of proteins to FTS-1 has previously been shown to dr...Biogen Idec acquires Brandeis spin-out
...ts of development and commercialization. Following regulatory approval, Syntonix is responsible for marketing FIX:Fc in North America and Biovitrum is responsible for marketing FIX:Fc in Europe, Russia, and the Middle East. Syntonix is pursuing other early-stage programs, including a long-acting factor VIII pr...Researchers probe health and safety impacts of nanotechnology
...noparticles and other forms of nanotechnology, and regulatory agencies such as the Environmental Protection Agen...'s the case, it could mean a lot of work ahead for regulatory agencies. "Typically, when you test a chemical, the response is the same regardless of formulation...Virginia Tech's System X supercomputer provides super tool for simulation of cell division
...pressing the genes that encode the proteins of the regulatory network. The model has 143 parameters that need to be estimated from the data. "That is a big problem," said Watson. "You can't do that by hand. You can't even do it on a laptop. It takes a supercomputer." In fact, it required more than 20,000 CPU ...Major link in brain-obesity puzzle found
...ive physiology at U-M. SH2B1 appears to play a key regulatory role in this system, through its direct influence on the processing of leptin and insulin signals in cells of the brains hypothalamus. Rui, who first discovered SH2B1s metabolic importance as a graduate student at U-M in the 1990s, worked on the n...ACS News Service Weekly PressPac -- January 24, 2007
... the European Union are giving industry additional regulatory incentive to go green with mainstream consumer products, the article adds. A companion story describes developments in getting detergents to deliver perfume to the laundry including approaches that adapt leading edge drug delivery technologies for...Carbon monoxide protects mice from multiple sclerosis
...emission, leading to the suggestion that there are regulatory mechanisms that counter the disease-causing inflammation. Using a mouse model of MS (known as EAE), researchers from the Gulbenkian Institute in Portugal show that increased expression of a protein known as HO-1, as well as administration of carbon m...JCI table of contents: January 25, 2006
...emission, leading to the suggestion that there are regulatory mechanisms that counter the disease-causing inflammation. Using a mouse model of MS (known as EAE), researchers from the Gulbenkian Institute in Portugal show that increased expression of a protein known as HO-1, as well as administration of carbon m...Turning a cellular sentinel into a cancer killer
...ould also be applied to study the effects of other regulatory molecules on cancers. "We think we have a really powerful technology that could be generalized, not only to study tumor suppressors, but also molecules that might be important drivers of tumorigenesis, making them good drug targets," he said. "For th...Cracking open the black box of autoimmune disease
...ls are commanded by a second group of cells called regulatory T cells. Regulatory T cells prevent biological "f... not attack the body's own tissues. Failure of the regulatory T cells to control the frontline fighters leads to autoimmune disease. Scientists previously disc...Tracing the pathways of neurofibromatosis
... Ras, PI3K and Akt to work in concert to inhibit a regulatory group of proteins called 'forkhead box O,' or FOXO. FOXO proteins are key players in regulating the genes responsible for programmed cell death and DNA repair two common culprits in cancer. "Our results raise the possibility that neurofibroma form...'Speechless' and 'Mute' help break the silence of the leaves
...to each other. Molecular conservation of such key regulatory genes between plants and animals genes that switch on and off cell-type differentiation programs from precursor stem cells is intriguing and exciting, Torii says....Scientists map key landmarks in human genome
...3,692 promoters (regions of DNA that interact with regulatory factors to control gene activity) within seven human cell lines, including malignant melanoma. Nucleosomes are spherical packing units for DNA. They consist of a length of DNA wrapped around a core, like ribbon around a spool that is made up of pro...Gene that makes people 'early to bed and early to rise' demystified
...t position 662 is replaced by glycine, prevented a regulatory enzyme from tacking a phosphate onto the encoded protein. Now, the researchers report additional evidence that the lost "phosphorylation" prevents a cascade of chemical modifications that are normally primed by the initial event. Moreover, they sh...Novel regulation of the common tumor suppressor PTEN
...cer Center have now identified fundamentally novel regulatory mechanisms of PTEN function. The findings from two related studies are published in the January 12 issue of Cell. The first is research by Dr. Xuejen Jiang's laboratory at Sloan-Kettering which identified a novel component that regulates PTEN. This ...JCI table of contents -- January 11, 2006
...n mice and humans a population of T cells known as regulatory T cells (Treg), which keep other immune cells from...: Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis AUTHOR CONTACT: David J. Rawlings University of Washington School of Medicine, ...Regulatory T cells require WASp if they are to prevent self-destruction
...n mice and humans a population of T cells known as regulatory T cells (Treg), which keep other immune cells from attacking the body's own tissues and causing autoimmunity, are also impaired in the absence of WASp. In the study, which appears online on January 11 in advance of publication in the February print...Wheat can fatally starve insect predators
...ction." The scientists currently are looking for regulatory regions in Hessian fly-susceptible wheat genes tha...s to halt the virulent insects, Williams said. The regulatory regions, or promoters, would be from genes that the fly larvae ordinarily manipulate so plants will ...Antibody therapy prevents type 1 diabetes in mice
... dependent on the induction of a certain subset of regulatory T-cells. If we can demonstrate this same genetic predisposition and therapeutic effect in human type 1 diabetes patients, then this may prove to be a significant step toward preventing this disease before it can take hold," he explained....Physicians face significant new liability risks with advent of personalized medicine era
...he ASU/Mayo Clinic M.D.-J.D. program. The legal, regulatory and ethical issues surrounding personalized medicine, or pharmacogenomics, is the focus of a March 2 conference at the College of Law. ( https://www.law.asu.edu/personalizedmedicine ) It is defined as using information about a person's genetic makeup...