T for two: Scientists show how immune system chooses best way to fight infection
...to emerge from the thymus as an effector cell or a regulatory cell. The research suggests that new treatments co...uence on whether a T cell becomes an effector or a regulatory cell," explains Professor Adrian Hayday of King's College London. "This may be clinically significan...What's the difference between mice and men?
... actual examples directly linking small changes in regulatory parts of genes to morphological differences have been scarce. While it may not be possible to swap regulatory sequences to turn a man into a banana, or even into a mouse, examination of these sequences may tell...New biomarkers for lupus found
...all chains of ribonucleic acid that have important regulatory functions in the body, particularly in suppressing genes. (RNA serves as the template for translation of genes into proteins.) The research is part of Mishra's broader focus on histones, the tiny spools in the nuclei of cells around which DNA winds ...Sea urchin genome is a biology boon and a computational feat
...to the cis-regulatory code, the blueprint for gene regulatory systems and networks and the functional maps of the control circuitry of the cell," Istrail said. "Now that we have the genome and transcriptome map, we can start to crack this code, which will reveal key insights into human genetics and evolution."...RNA map provides first comprehensive understanding of alternative splicing
...tive splicing is that a relatively small number of regulatory splicing factors acting in concert on a single transcript can potentially generate a large number of different protein variants," says Darnell. "There is a converging set of observations indicating that as neurologic diseases are better understood,...Insight into evolution of adaptive immunity boosted by sea urchin genome sequencing
...as one of the leading models for analyzing genetic regulatory networks that control development. Sea urchins bel...l help us to better understand how complex genetic regulatory circuits are assembled from components that originally may have been dedicated to very different tas...JCI table of contents: November 9, 2006
.../article.php?id=28184 AUTOIMMUNITY: Multiple regulatory cell types can't keep self-destructive immune cell...mally keep the destructive ones in check (known as regulatory T cells) are impaired in individuals with MS. Previous studies have focused on a regulatory T cell s...Scientists harness diptheria toxin and interleukin 2 to help the immune system attack melanoma
... antigens such as tumour cells, and suppressive or regulatory T cells (Tregs), which turn off activated immune c...y. Dr Chesney explained: "Recently a subset of regulatory T cells has been found to directly suppress the activation of the anti-tumour T cells, but it was al...Transplanted photoreceptor precursor cells restore visual function in mice with retinal degeneration
...y building on previous research, using an NRL gene regulatory element to tag the rods with a green fluorescent protein. This enabled Kellogg scientists to illuminate the rods, which begin as unspecified cells and gradually differentiate into cells dedicated to light reception. "One of our critical discoveries,"...St. Joseph's provides tissue processing services to researchers in hopes of finding a cure
... created an efficient and centralized process with regulatory oversight to ensure human safety. More than 2,220 specimens have been gathered from approximately 950 patients. Eighty percent of St. Joseph's tissue bank is neuro-based but specimens including lung, heart and ovarian tissue are also collected. Al...Fake pesticides threaten food safety
...ents and regulators to use their powers to enforce regulatory policies....Stem cells engage in dialogue with the cells that regulate their futures
...se niches - nest-like microenvironments made up of regulatory cells in order to self-renew. Stem cells can divide and turn into many types of new cells. The niches help regulate the amount and kinds of new cells produced to meet current demands. The niches also help maintain a supply of stem cells for later...SNM: Exploring molecular imaging potential
...tice, and one of the challenges to the medical and regulatory communities is to facilitate the introduction of new imaging techniques into patient management. As technology advances, scientists will further their ability to use different probes with the whole spectrum of molecular imaging modalities to identify...Key molecular signaling switch involved in allergic disease identified
...enzyme called ADAM10 that releases a major allergy regulatory protein from the surface of cells and thereby prom...gic disease can be modulated by high levels of the regulatory protein, known as CD23, which ultimately results in a decreased production of IgE. He said that when...Bee genome information housed at Texas A&M University
...ng ways of treating insects with this new class of regulatory compounds, could "profoundly and very specifically change their genetic responses," he said. "RNAi has the potential to control production of different castes for colony maintenance, influence honey bee pollination behavior so important to crop pro...New insight into cell division
...s of the molecular reactions between the different regulatory proteins and then investigate how these interactions differ in healthy cells and cancer cells. Long term, this could lead to the development of new diagnostic or therapeutic strategies....New behavior may use old genes
...archers next identified genes encoding proteins in regulatory pathways based on their genome location as potentially responsible for differences in the social foraging behavior of the honeybee. These pathways support the ongoing work of Amdam and Page on the evolutionary basis for social behavior, and also are...Sweet yet sophisticated: Honey bee genome lends insight into sociality, sensation and sex
...volves several interlocked pathways and associated regulatory components. Using the honey bee genome sequence, a team of researchers led by Dr. Guy Bloch has identified and characterized the core set of genes responsible for circadian rhythms in honey bees. As described in Genome Research , Bloch's group fo...HFI-1 gene has key role in both oxygen sensing, heat shock pathway
...ity of Oregon researchers have found an unexpected regulatory link between cellular responses to hypoxia and heat shock. Central to the discovery is a gene known as Hypoxia-Inducible Factor-1 (HIF-1) that is critical for both normal and pathological changes, making it a potential target for both health promotio...VIP's importance to temperature regulation may be pre-empted by substance P
...ted in the body and have been associated with many regulatory roles. Reporting in a paper appearing online ahead of regular publication by the Journal of Physiology, two UO researchers concluded that when NK-1 receptor activity was diminished, so went the dilation of blood flow necessary for bringing warm blo...