OHSU study: Bacterial switching mechanism key to survival
...onsume." The survival technique, carbon catabolite repression (CCR), is one of the most fundamental and oldest mechanisms used for environmental sensing and signalling in bacteria, and it's critical for successful competition in diverse and frequently changing conditions. As a neutral molecule, glucose is able ...Asymmetric organs and microRNA-directed DNA modification
...authors speculate that microRNAs provide a general repression of PHB and PHV during development and that specific regions of the plant may have the ability to overcome this repression, thus permitting varying morphologies, as is observed on the top and bottom of Arabidopsis leaves. Ning Bao, Khar-Wai Lye, and...Discovery of first demethylase molecule, a long-sought gene regulator
..., so its removal would be consistent with the gene repression function they had identified. Now that the first demethylase has been recognized, researchers will certainly find more. "This cannot be the only demethylase," said Shi. Genes turning on at the wrong time or in the wrong place is a hallmark of cancer ...Signs of aging: Scientists evaluate genes associated with longevity
...ed age. "We speculate that the apparent metabolic repression in early and mid-life adults contributes substantially to the observed longevity of daf-2," says Dr. Julius Halaschek-Wiener, a researcher at the BC Cancer Agency's Genome Sciences Centre and first author on the study. Another notable observation was...Eye candy: Transcriptional control of vertebrate eye development
...ues found that Vax1 and Vax2 are necessary for the repression of Pax6 expression, the ventralization of the eye field, and subsequent development of the optic nerve. Dr. Lemke notes that "in many respects, the eyes represent a default differentiation pathway for the front end of the developing brain. To make an...JCI table of contents, July 1, 2005
... angiogenesis via TNF-alphainduced transcriptional repression of cyclin A AUTHOR CONTACT: Douglas W. Losordo Tufts University School of Medicine, Boston, Massachusetts, USA Phone: (617) 789-3474; Fax: (617) 789-6362; E-mail: douglas.losordo@tufts.edu View the PDF of this article at: https://www.the-jci....... heterozygosity, but PTEN is haploinsufficient for repression of carcinogenesis resulting from Tsc2 heterozygosity. Specifically in the kidney, the researchers determined that Tsc2-heterozygous tumors need to loose the other copy of Tsc2 in order to become malignant. While the studies do have some conflicting o...Scientists get look at genes' defensive playbook
... consequences of infection fighting. "The apparent repression of genes that occurs has never been fully appreciated," said Henry Baker, Ph.D., associate director of the UF Genetics Institute and director of the UF lab that performs genomic analyses for the consortium. "Initially, more than half of the genes bec......evance to human disease, as improper activation or repression of genes that regulate cellular growth is a common...re beginning to understand how gene activation and repression is altered in cancer cells, and how that leads to tumor growth. However, the design of targeted tre...Researchers discover new form of cancer gene regulation
...r events, these signals trigger gene activation or repression through action of transcription factors in the nucleus of the cell. The altered gene expression profile then results in cellular differentiation, cellular proliferation or cellular death as pattern formation proceeds. An important signal transdu......dditional mouse models, which allow the reversible repression or activation of IKK2 at any time in neurons. "The unique advantage of this system is that we can specifically induce or block this signaling pathway at virtually any time and selectively in neurons," Wirth emphasizes. Putting all of this expertise t...Researchers uncover cellular clues to vitamin A resistance in lung cancer
...her organ sites," the authors write. "The frequent repression of RAR-beta-1' in lung carcinogenesis underscores its likely important biologic or clinical role. Identification of pharmacologic approaches that restore RAR-beta-1' expression would provide a basis for future retinoid-based combination strategies f......R protein as a co-factor required for SXL-mediated repression of msl-2 translation. Dr. Gebauer points out that the "UNR is, therefore, an essential component of a translational control mechanism that prevents dosage compensation in female cells," and Dr. Hentze adds that "These new studies teach us how a prot...Turkish scientist's discovery of how proteins work
...upport he received from Cedar. His studies on gene repression suggested a mechanistic connection between DNA replication timing and gene expression. Zhang received his Ph.D. degree in 2004 and was awarded the Aharon Katzir Prize. He is a postdoctoral fellow in Daniel Habers laboratory at the Cancer Center, Mass...Translational derepression & oncogene expression in breast cancer cells
...egion (UTR) of Her2 mRNA can inhibit translational repression by the 5' upstream open reading frame (uORF), and thereby increase Her2 translation in breast cancer cells. Like a subset of eukaryotic genes that are important regulators of gene expression, the 5'UTR of Her-2 encodes a uORF that interferes with eff...How embryonic stem cells maintain their identity
...olycomb protein, further supporting a link between repression of developmental regulators and embryonic stem cell identity. "This paper connects the two classes of embryonic stem cell regulators and provides a foundation for understanding the basic circuitry underlying human development," Young said. In the sec...Location, location, location: Transcriptional activity and nuclear position
...tein complexes associated with gene activation and repression at the nuclear periphery in mammalian cells is a high priority."...Satellite images obtained by AAAS program provide strong evidence of Zimbabwe repression
...atellites may be able to signal that a campaign of repression is beginning. Bromley said that other scholars are trying to assemble and analyze a range of data from past conflicts--demographic and economic data, drought and other weather data, eyewitness accounts and satellite images--to find common patterns th...Salk scientists get to the root of plant cell fate
...t is produced," he explains. Since transcriptional repression plays such a key role in animal embryonic development, the finding that a co-repressor controls polarity in plants was surprising, says Long. "We thought that because plants and animals are believed to have largely developed independently from each o......ression by at least two independent mechanisms: by repression of translation and/or by induction of mRNA degradation. This provides an explanation for changes in mRNA levels observed at least for a subset of miRNA targets."...