UCLA scientists transform HIV into cancer-seeking missile
...it is possible to develop an effective carrier and reprogram it to target specific cells in the body." The UCLA team employed a two-step approach to transform HIV into a cancer-seeking machine. First, the scientists used a version of HIV from which the viral pieces that cause AIDS had been removed. This allo...Genomic analysis to become tool for studying trauma patients
...l. Such changes in gene activity can, for example, reprogram white blood cells, immune system cells that circulate in the bloodstream. This reprogramming alters the relative populations of the different types of white blood cells and the genes they express. One white blood cell, the neutrophil, normally makes...Double triumph in stem cell quest
...ea is that the cytoplasm of an enucleated ESC will reprogram the donor nuclei, turning the fused cell into an ESC too. The result, Verlinsky told a conference on pre-implantation genetics in London last week, is new lines of ESCs that are genetically identical to the adult donor. He calls the new cells stembri...Harmful chemicals may reprogram gene response to estrogen
...that an environmental agent can actually change or reprogram the gene so that it functions differently. "This study is telling us that an environmental reprogramming of a normal response, combined with an inherited gene defect, work together to promote cancer," said NIEHS Director David Schwartz, M.D. "If this...Washington State University study points to role of toxins in inherited disease
...inding that an environmental toxin can permanently reprogram a heritable trait also may alter our concept of evolutionary biology. Traditional evolutionary theory maintains that the environment is primarily a backdrop on which selection takes place, and that differences between individuals arise from random mu...Cloning advance: Researchers demonstrate direct transfer of terminally differentiated cell nuclei
...e question of whether the egg cytoplasm can itself reprogram a fully differentiated nucleus. It therefore remains a possibility that many cloned mammals might be derived from rare stem cells present in donor-cell samples rather than derived from differentiated cells themselves. In a new study publishing in the...Scientists discover the molecular switch for nerve cells' insulating jelly rolls
...e cells. "Is it possible that this same switch can reprogram a nerve cell that has lost myelin due to injury or disease to repair itself? That is a key question that our laboratory and others are now actively trying to answer," he says....Cloned stem cells prove identical to fertilized stem cells
...l. For a viable fetus to develop, the egg needs to reprogram the genome of the skin cell, shutting off genes specific for skin tissue and turning on genes needed for embryonic development, genes that are normally dormant in tissue-specific cells. In other words, the egg needs to erase all tissue-specific memor...Bone and cartilage growth to blame for heart valve disease
... high cholesterol that stimulates certain cells to reprogram into bone cells in the aortic valve and cartilage cells in the mitral valve, says principal investigator Nalini Rajamannan, MD, newly appointed director of the Center for Heart Valve Disease in the Bluhm Cardiovascular Institute of Northwestern Memor...Durable critters providing insight for human egg preservation
...r embryonic stem cells, he says. Eggs, which can reprogram cell function by turning genes off and on, can produce cells that can become essentially anything, Dr. Eroglu says. If he can better understand how they do this, regular body cells might be reprogrammed in a test tube to embryonic-like stem cells for...Wheat can fatally starve insect predators
...k, she said. In addition, some virulent larvae can reprogram plant development so that cells in leaves and the base of the plant where the insects feed pump out nutrients favored by the insect. If this happens then even the weak, avirulent larvae on the same leaf have a chance to survive. The researchers dis...Can engineered immune cells stop AIDS?
... to create B lymphocytes. The researchers want to reprogram these bone marrow cells by adding genes that will instruct the cells to produce rare antibodies such as B12, 4E10, 2G12 and 2F5. Wang says these antibodies are known to neutralize the virus. "In laboratory tests, we remove harmful genes coding ...Cancer cells 'reprogram' energy needs to grow and spread, study suggests
... at Johns Hopkins have found that cancer cells can reprogram themselves to turn down their own energy-making machinery and use less oxygen, and that these changes might help cancer cells survive and spread. The Hopkins scientists report that the loss of a single gene in kidney cancer cells causes them to st...A twist of fate -- Reprogrammed fibroblasts resemble embryonic stem cells
...se potential problems is to find a way to reliably reprogram an individuals differentiated tissue cells into cells that behave like embryonic stem cells and can give rise to any fetal or adult cell type. Recent research discovered that expression of four transcription factors can induce a pluripotent state i...Reprogrammed fibroblasts identical to embryonic stem cells
...vating four genes in a mouse skin cell, they could reprogram that cell into a pluripotent state resembling an embryonic stem cell. However, the resulting cells were limited when compared with real embryonic stem cells, and the Kyoto team was unable to generate live mice from these cells. A team of researche...UCLA researchers reprogram normal tissue cells into embryonic stem cells
... at UCLA were able to take normal tissue cells and reprogram them into cells with the same unlimited properties...potentially replace a controversial method used to reprogram cells, somatic cell nuclear transfer (SCNT), sometimes referred to therapeutic cloning. To date, SCN...