Toward a better understanding of taste and smell impairments
... track chemosensory performance and symptoms among rescue and construction workers at the World Trade Center site. The third component investigates taste loss in a population where this condition is common. Over 90 percent of all head and neck cancer patients who receive radiation therapy experienc...Embryonic stem cells correct congenital heart defect in mouse embryos
... the Id protein impairs the stem cells' ability to rescue these embryonic mouse heart cells. These cells are...e Id knock-out embryos were born, but with partial rescue of cardiac defects and abnormal gene expression profiles. As a result, Id knock-out pups whose mothe...New DNA repair enzyme makes mistakes to save lives of cells
...sult in the cell not surviving, POL-Q comes to the rescue by performing its two-step handiwork. First, it replaces the site of a missing or chemically changed base by inserting a new base even if its choice from one of the four bases is not complementary to the base opposite. In a correct sequence strand, ...JCI table of contents, December 1 2004
...ww.the-jci.org/press/23705.pdf Stem cells to the rescue or not? The use of stem cells obtained from bone marrow for the treatment of some skeletal or heart diseases is an attractive long-term strategy to deliver normal stem cells, capable of developing into any cell type of the body, to injured tissue i...Blocking cell suicide switch fails to stop prion damage in mouse brains
...ansgenic mouse model. But when they found a way to rescue those cells, they were astonished to discover the mice still became sick. Now they believe previous efforts to find the beginnings of the mouse disorder may have been focused on the wrong part of the brain cell and are plotting new directions for res...The giant eagle of Middle Earth
...e Rings features enormous eagles swooping down to rescue Sam and Frodo from a desolate New Zealand landscape masquerading as Mordor. The image of giant eagles flying around New Zealand, while fanciful, is not so far-fetched as it might appear. New genetic data published in the freely-available online jou...Ancient DNA helps solve the legend of giant eagles
..., 2005 Gigantic eagles swooping from the skies to rescue Frodo and Sam in the Lord of the Rings may not be just the stuff of legends and fairytales, according to research published in the journal PloS Biology . McMaster University anthropologist Michael Bunce has shed new light on the evolution of the ext...EB and IUPS - Where cures of tomorrow can be seen in the science of today
... of diving and extreme physiology at depth and the rescue mechanisms of the heart; regenerative capacity of the heart; the molecular basis of epithelial disease; and long-term plasticity and spinal cord injury. American Society for Biochemistry and Molecular Biology (ASBMB) symposia reflect the society's...Diabetes' link to obesity broken in mice
...esult. To follow up, Kelly's lab is attempting to rescue the new mouse line from glucose intolerance and insulin resistance. PPAR-alpha seems to convince cells that they don't need glucose because they have plenty of energy available from fat, so Kelly will try to increase energy demand or trick cells int...Thumbnail sampler of 10 diverse physiology papers from IUPS 2005
...r findings indicate that chaperone competition can rescue delta-F508CFTR from destruction, permitting its channel activity to appear at the cell surface. Also, the delivery of mutant protein fragments may provide a therapy for CF. "Dietary interventions reduce muscle weakness in unloaded muscle." Sandrin...Next-era targeted therapy overcoming Gleevec's shortcomings
...rson: Abstract 3971 AMN107 appears to effectively rescue patients with chronic myeloid leukemia (CML) who d... more than 90 percent. "If you can take a pill and rescue people who failed the current standard of care, that is remarkable," says the study leader, Francis ...JCI table of contents May 2, 2005
...n and signaling in the liver was not sufficient to rescue normal in vivo responses to insulin. This restoration did not affect the ability of insulin to inhibit liver glucose production, suggesting that the indirect effects of insulin on the liver determine hepatic glucose production in mice. A companion p...Wild grasses and man-made wheats advance research capabilities
...e from a wild species to a hexaploid wheatand then rescue and nurture the developing embryo to get a plant, he said.Hexaploid wheat has three genomes or sets of chromosomes. This is themakeup of the typical bread wheat. After such a cross, the initial plant will have genetic abnormalities.A series of cro...Runyon award goes to third Vanderbilt-Ingram scientist since 2002
...y Clinical Investigator Award is designed to "help rescue an endangered species," the physician willing to devote his or her career to the development and application of new diagnostic, therapeutic and prevention strategies for cancer through clinical and translational research. The foundation was created ...EPO upholds limited patent on BRCA2 gene
...mittee, said: "The patent owners have been able to rescue a small bit of their original patent on BRCA2 testing by putting Ashkenazi women into their claim. This apparently renders the test for the 6974delT mutation, which happens to be frequent in the Ashkenazi population, inventive, novel and industrially...Salivating aphids and dynamic proteins
...ow special dynamic proteins are involved in 'plant rescue systems' and how aphid's saliva can overcome their defence mechanism. Bean plants contain contractile protein bodies (forisomes) which change their shape in response to calcium (released during stress). In reaction to wounding, forisomes block the s...Elevated temperature enhances success of viral cancer therapy
...refore, induction of the heat shock response could rescue ONYX-015 replication in resistant tumor cells. According to Dr. O'Shea, "Our data suggest that a clinical strategy that does not advocate the use of pharmacological agents to suppress fever would favor the tumor-selective replication of ONYX-015. Thi...U Iowa researchers prevent hereditary deafness in mice
...that developing the technique to produce long-term rescue of hearing loss is a future focus for his research team. In addition to Smith and Maeda, the research team included Kunihiro Fukushima and Kazunori Nishizaki of Okayama University Graduate School of Medicine in Okayama, Japan. The study, which was pu...Carbon monoxide: Poison gas or anti-inflammatory drug?
...ipients. But U-M scientists discovered they could rescue the mice by having them inhale CO-enriched air (100 ppm) for two weeks after transplantation, or by giving them a drug that induces high levels of Hmox expression. "We found that naturally occurring levels of the Hmox enzyme were not high enough to ...Research suggests fitness of Florida panthers improved by limited breeding with Texas animals
...ew. "A lot of scientists said this kind of genetic rescue would not work. They said if a species is rare, an... was himself skeptical about the success of such a rescue attempt in his 1991 book, "The Balance of Nature? Ecological issues in the conservation of species a...