News tips from the Journal of Neuroscience
...xin1 reduced vesicle docking. However, Munc18-1 NV rescued release, albeit to a lesser extent than wild type. Thus, Munc18 regulates a postdocking (priming) step by a mechanism that does not require binding to syntaxin1. In fact, the authors suggest that this second interaction either involves dissociation f...News tips from the Journal of Neuroscience
... immediate and long-term memory deficits that were rescued by expression of the human Nf1 gene (hNF1). Flie...stream of the GRD but involved in cAMP regulation, rescued immediate, but not long-term memory. Thus, these two Nf1 domains appear to have independent effects....JCI table of contents -- June 1, 2007
...thesis causes severe glomerular proteinuria and is rescued by N-acetylmannosamine AUTHOR CONTACT: Marjan Huizing National Human Genome Research Institute, NIH, Bethesda, Maryland, USA. Phone: (301) 402-2797; Fax: (301) 480-7825; E-mail: mhuizing@mail.nih.gov Raymond MacDougall Associate Directo...Jefferson scientists use gene therapy to reverse heart failure in animals
...rapy. They found that beta-blockers only partially rescued the animals' hearts in failure and that S100A1 gene therapy alone was significantly better at improving heart function in the model. "Importantly, the combination of the two was also therapeutic and in some indices studied there were additive effects...News tips from the Journal of Neuroscience
... plexinA3 mRNA, which did not bind the morpholino, rescued the phenotype. Branching and exiting were exacerbated by coinjection of morpholinos that blocked expression of sema3A1 or sema3A2. Sema3A1 in particular appeared to contribute to excess branching, whereas sema3A2 appeared to regulate the increase in ...News tips from the Journal of Neuroscience
...ure, and had reduced tolerance. These effects were rescued by transgenic pan-neuronal expression of Homer or when Homer expression was driven in the ellipsoid body, part of the central complex thought to be involved in control of locomotor activity. 2. Experience-Dependent Gustatory Development Jamie E....Blood sugar's manufacture limited by building blocks' supply
...servation, injection of pyruvate, but not alanine, rescued the mice from their fasting hypoglycemia. The findings point to a novel form of control over glucose levels, the researchers said. Ultimately, this "window into glucose control" might also have implications for diabetes treatmenta condition charact...News tips from the Journal of Neuroscience
... and bite at the newcomer. The authors treated the rescued intruder with thymidine analogs at various time points relative to the stress to track changes in the birth and survival of new neurons. The episode raised corticosterone levels indicative of the stress but did not impact the number or immediate surv...JCI table of contents: February 15, 2006
...resistance in generalized PPAR-gammadeficient mice rescued from embryonic lethality AUTHOR CONTACT: Richard M. Mortensen University of Michigan Medical School, Ann Arbor, Michigan, USA. Phone: (734) 763-2021; Fax: (734) 936-8813; E-mail: rmort@umich.edu . David S. Milstone Brigham and Women's Hospital, ...News tips from the Journal of Neuroscience
...ansporter), which controls cytosolic levels of DA, rescued flies from the mutant parkin phenotype. The idea is that dopamine oxidation leads to modification of parkin, particularly mutant forms, reducing its E3 ligase activity and increasing susceptibility to cell toxicity....News tips from the Journal of Neuroscience
...cause of respiratory failure, and thalamic neurons rescued from these animal almost completely lacked glutamatemediated synaptic transmission as studied in autaptic cultures. Neurons from heterozygous mice, on the other hand, showed reduced amplitude of miniature excitatory postsynaptic responses, indicating...News tips from the Journal of Neuroscience
...NF expression in mutant granule cells and could be rescued by a 5 d treatment of the cultures with exogenous BDNF. In vivo , the dendritic abnormalities were less dramatic, but still apparent. 2. Determining Sites of Synapse Formation Shasta L. Sabo, Raquel A. Gomes, and A. Kimberley McAllister What de...JCI table of contents: Oct. 12, 2006
... authors demonstrated that inhibition of myostatin rescued the muscle wasting in these mice. The study indica...E: Muscular atrophy of caveolin-3deficient mice is rescued by myostatin inhibition AUTHOR CONTACT: Yoshihide Sunada Kawasaki Medical School, Kurashiki, Japan....News tips from the Journal of Neuroscience
...t. Using a cortical slice preparation, the authors rescued the defects in MAM-treated slices by coculture with normal slices, suggesting that a soluble factor was required for positioning of C-R cells. Inhibition of CXCR4, the receptor for SDF1 that is secreted by the leptomeninges, blocked the rescue. In u...News tips from the Journal of Neuroscience
...dult mice, PNs were severely reduced. NSC implants rescued the number of PNs and improved motor performance. ...ther than newly differentiated NSCs. PNs were also rescued by NSCs in organotypic slice cultures. Direct contact between transplanted NSCs and host cells was r...Researchers reverse Parkinson's symptoms in animal models
...hat if they identified genes whose over-expression rescued a cell, that would tell them something about how alpha-synuclein made the cell sick in the first place. Most of the proteins that they identified pointed to a pathway that involves two cellular organelles, the endoplasmic reticulum (ER) and the Golg...News tips from the Journal of Neuroscience
... identical central SNARE motif with synaptobrevin, rescued transmission. An electrostatic interaction between...tial because an R-Q substitution in synaptobrevin rescued evoked and spontaneous release. However, spacing between the SNARE motif and C-terminal transmembran...Novel stem cell technology develops a new cell for repairing spinal cord injuries
... nerve fibres are severed in the spinal cord, were rescued when their cut nerve fibres interacted with the astrocytes transplanted into spinal cord injuries. In contrast, transplanted precursor cells failed to suppress scar formation or promote the growth of any nerve fibres across the injury site. Important...News tips from the Journal of Neuroscience
...P that becomes layers 2/3. Overexpression of MDGA1 rescued the migration of layer 2/3 neurons. 3. The Subdivisions of Visual Working Memory Harald M. Mohr, Rainer Goebel, and David E. J. Linden According to the "domain-specific" view, visual working memory tasks are separated in the lateral prefrontal cort...New antimicrobial compound adheres to skin to promote healing
...o heal skin ulcers on a whale named Gasper who was rescued from a Mexico City amusement park and is now a popular resident of the Georgia Aquarium. Petroleum-based ointments are commonly used in treating skin infections, but Capomacchia said that petroleum can be toxic and inhibit healing,"Using a petroleum...