News tips from The Journal of Neuroscience
...d after the first 21 amino acids of the C terminus rescued LTD, whereas one containing only 13 amino acids of the C terminus did not. Expression of a peptide containing amino acids C1420 acted as a dominant negative, blocking LTD perhaps by interfering with a δ2PICK1 interaction. 2. Growing Axons Find...Adaptation to oxygen deprivation elucidates tumor physiology
...ng HIF-1 limited toxic free radical generation and rescued the cells from hypoxia-induced death. Denko's team similarly demonstrated in tumor cells that HIF-1 causes a drop in oxygen use, resulting in increased oxygen availability and decreased cell death under low oxygen conditions--findings that might hav...Steps made toward overcoming biological obstacles to cell therapy for cancer
...ed through experimentation that the cells could be rescued from this tolerant state and encouraged to prolife...ns, and that these CD8+ T cells can potentially be rescued and expanded for use in tumor immunotherapy. The authors of the Nature Medicine article, "Interleuk...Swiss researchers develop all-in-one remote control gene expression tool
... application, dying cells (such as neurons) can be rescued by introducing a gene that expresses a growth factor. Thanks to the remote control carried in the lentivirus the expression of this growth factor can now be turned off when the desired effect is achieved, thus preventing unharnessed growth otherwise...Teaching worms good taste: Researcher reveals the cell biology of learning at ASCB meeting
...ng the tph-1 gene back to their ADF neurons, Zhang rescued the mutants' ability to learn aversion. Further experiments also identified a serotonin-gated chloride channel, MOD-1, functioning in interneurons downstream of ADF to promote aversive learning. Apparently the worm learns to eat right, one bad taste ...Disease-causing protein protects against nerve damage in Parkinson's disease
...ic Neuroscience and lead author of the study. "The rescued animals can live for one year or longer." The researchers also bred mice that produced neither CSP-alpha nor alpha-synuclein and found they suffered neurodegeneration faster than mice just lacking CSP-alpha ? another sign that alpha-synuclein protect...Studies find possible drug targets for improving vascular health
... to reverse the effects of the missing gene, which rescued limbs in danger of dying because of ischemia. Ischemia is a severe reduction of blood flow and nutrients, usually because of a blood clot or atherosclerosis. Sessa said the study in PNAS implies that therapeutic approaches to improve blood flow and ...JCI table of contents July 1, 2005
...f the chromogranin A gene: Elevated blood pressure rescued by the human ortholog AUTHOR CONTACT: Sushil Mahata University of California, San Diego, La Jolla, CA USA Phone: 858-552-8585 x2637; Fax: 858-642-6425; E-mail: smahata@ucsd.edu View the PDF of this article at: https://www.the-jci.org/article.php?i...A new study examines how shared pathogens affect host populations
...is frequency-dependent transmission, a host can be rescued from pathogen-mediated extinction by the presence of a second host with which it shares a pathogen. Sharing a pathogen among one or more alternative species may actually be limiting the spread of the pathogen in any one particular host population. Th...Buying time through 'hibernation on demand'
...ple: In May 1999, a female Norwegian skier was rescued after submersion in icy water for more than an hour. When rescued she was clinically dead with no heartbeat, no respiration, and her body temperature had fallen to 57...Highlights of January 2005 issue of Biology of Reproduction
... embryos, and the blocking effect of osmolarity is rescued by glycine. These results not only clear up long-standing confusion about the etiology of the 2-cell block but also highlight the important effects of culture conditions on experimental design. (The full text of this paper is available from Biology o...Injured whooping crane recovering at USGS Patuxent Wildlife Research Center
...Patuxent flock was a bird named Canus who had been rescued from the northern breeding grounds in Canada in 1964 after he was found with a broken wing. Canus lived and reproduced successfully at Patuxent for almost 40 years. The USGS Patuxent is active in several whooping crane recovery and research progr...Embryonic stem cells correct congenital heart defect in mouse embryos
...enetically predisposed to develop a lethal defect, rescued the heart from developing the disorder by not only producing normal daughter cells that were incorporated into the defective embryonic heart but also by releasing biological factors into the nearby vicinity. This prevented neighboring heart cells fro...