MGH researchers confirm that bone marrow restores fertility in female mice
...rrow that restores recipient oocyte production and rescues long-term fertility. However, we do know without question that immature oocytes can be generated from cells in adult bone marrow, but they are probably not critical to the fertility rescue observed after the transplants. Since the 2005 Cell pape......th the common anti-inflammatory aspirin completely rescues hair loss in these pups....JCI table of contents: July 19, 2007
...heart disease. TITLE: Mediating ERK1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome AUTHOR CONTACT: Jeffrey Robbins Cincinnati Childrens Hospital Medical Center, Cincinnati, Ohio, USA. Phone : (513) 636-8098; Fax: (513) 636-5958; E-mail: jef.robbins@cchmc.org View ...JCI table of contents -- April 19, 2007
...t failure. TITLE: Inhibition of p38-alpha MAPK rescues cardiomyopathy induced by overexpressed beta2-adrenergic receptor, but not beta1-adrenergic receptor AUTHOR CONTACT: Dorothy E. Vatner University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA Phone: (973) 972-8920; Fax: (97...Mind over matter: SH2B1 in the brain regulates obesity
...at replacing SH2B1 only in the brain of these mice rescues them from obesity, indicating that targeting SH2B1 in the brain might be a new avenue of research for the development of treatments for obesity and type II diabetes. In the study, which appears online on January 18 in advance of publication in the F...JCI table of contents: Jan. 18, 2007
...at replacing SH2B1 only in the brain of these mice rescues them from obesity, indicating that targeting SH2B1 in the brain might be a new avenue of research for the development of treatments for obesity and type II diabetes. In the study, which appears online on January 18 in advance of publication in the F...NYU, Scripps finding offers new path for treatment of diabetes
...chemical compounds to find one hit compound, which rescues the mutant C. elegans (diabetics model) from diabetes. Then, they identified the target protein, which was found to be the enzyme GAPDH. GAPDH has long been known as one of the important glycolytic enzymes, and its function is affected by insulin. Ho...A humble aquarium fish may be the key to new therapies for birth defects
...hat it works almost as well as the fish enzyme and rescues embryos from a number of the mutant's defects. That demonstrated just how similar the molecular mechanisms for handling copper are in the zebrafish and in humans. This didn't come as a big surprise because the researchers know that evolution tends...Cause of neuronal death in Down's syndrome, Alzheimer's disease could be surprisingly simple
...trophin "brain-derived neurotrophin factor" (BDNF) rescues neuronal death in another mouse model of Down's syndrome. Salehi et al. found that the NGF transport disruption leads to the degeneration of "basal forebrain cholinergic neurons" (BFCNs) important for cognitive function. This deterioration of BFCN...Steps made toward overcoming biological obstacles to cell therapy for cancer
...tigen. It's not known precisely how proliferation rescues these cells, but the expanded tumor-reactive T cel...rs of the Nature Medicine article, "Interleukin-15 rescues tolerant CD8+ T cells for use in adoptive immunotherapy of established tumors," were Drs. Ryan M. Te...JCI table of contents, February 1, 2006
...centrations suppress PI3K activity." TITLE : GDNF rescues hyperglycemia-induced diabetic enteric neuropathy through activation of the PI3K/Akt pathwayAUTHOR CONTACT: Shanthi Srinivasan Emory University, Atlanta, Georgia, USA Phone: (404) 727-5298; Fax: (404) 712-2980; E-mail: ssrini2@emory.edu View the P...JCI table of contents: December 15, 2005
...TITLE: Intramuscular viral delivery of paraplegin rescues peripheral axonopathy in a model of hereditary spastic paraplegia AUTHOR CONTACT: Elena I. Rugarli National Neurological Institute, Milan, Italy Phone: 39-02-23942614; Fax: 39-02-23942619; E-mail: rugarli@istituto-besta.it View the PDF of this a...Recreating 'Flowers for Algernon' with a happy ending
... a key learning and memory pathway, and completely rescues the most common genetic cause for learning disabilities. We don't have to do extensive clinical trials for toxicity or safety these were already completed for other uses."...JCI Table of contents August 1, 2005
...of this data. TITLE 1: Phosphoinositide 3-kinase rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury AUTHOR CONTACT 1: Anthony Rosenzweig Massachusetts General Hospital, Charlestown, MA USA Phone: 617-726-8286; Fax: 617-724-7387; E-mail: arosenzweig...JCI table of contents May 1, 2005
...he-jci.org/article.php?id=24140 PHYSIOLOGY BH4 rescues a bruised heart B4 breaking Heart failure can result from chronic hypertension, pressure overload and consequent overgrowth of the organ. In a study appearing online on April 14 in advance of the print publication of the May issue of the Journal of...JCI Table of Contents, March 1, 2005
...tic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury AUTHOR CONTACT:Barasch, Jonathan Columbia University, New York, NY USA Phone : (212) 305-1890; Fax: (212) 305-3475; E-mail: jmb4@columbia.edu View the PDF of this article at: https://www.the-jci.or......s://www.the-jci.org/press/22218.pdf Gene therapy rescues the failing heart Heart failure remains a leading...re. TITLE: Cardiac adenoviral S100A1 gene delivery rescues failing myocardium AUTHOR CONTACT: Patrick Most or Walter J. Koch Center for Translational Medicine...