A friendly foe -- Bacteria residing in the gut boost immune response to tumors
...uption of the population of bacteria that normally reside in the gut without causing disease also plays a role in the effectiveness of this therapeutic approach for cancer. A specific population of bacteria present in our gut is crucial to our health. However, some treatments for cancer, particularly thos...JCI table of contents -- July 26, 2007
...uption of the population of bacteria that normally reside in the gut without causing disease also plays a role in the effectiveness of this therapeutic approach for cancer. A specific population of bacteria present in our gut is crucial to our health. However, some treatments for cancer, particularly thos...MicroRNA works with Ago2 protein to regulate blood cell development
...marrow of adult mice where their blood stem cells reside OCarroll conditionally knocked out the gene that encodes Ago2. Two months later, OCarroll observed that they had developed anemia and enlarged spleens, and noted that although the stem cells still gave rise to all blood cell types, the development o......dentify, and sequence communities of microbes that reside in termite hindguts, and his lab at Stanford is custom building chips for other scientists interested in pursuing any culture-resistant microbe or discovering the dark matter of a specific environment....TU Delft tracks the influence of a cancer inhibitor on a single DNA molecule
...d that topotecan only causes the TopoIB protein to reside longer than normal on the DNA molecule, disturbing the cell division and damaging the (cancer) cell. But the Delft researchers have now discovered to their surprise that adding topotecan also dramatically impedes the unwinding and that DNA loops accu...How 'memory' T cells curb the spread of viruses throughout the body
...lymph nodes are not just organs where immune cells reside and proliferate, but also are the sites where a ma...fact, prevent viral diseases. CD8 T cells normally reside in lymphoid organs such as the lymph nodes. It was thought that to protect from disease, memory CD8...UVa-led team uncovers important secret in gene replication
...ressor genes, the ones that turn off cancer cells, reside in areas of the genome with asynchronous replication, the cancer cell can turn such genes off merely by mutating the one active copy instead of going through the trouble of separately mutating both copies. Dutta and colleagues are now gearing up fo...Cancer stem cells can go it alone
...ted with uncontrolled cell proliferation when they reside within their normal environment or niche. Cancer stem cells, however, are not equally responsive to environmental cues that repress uncontrolled cell proliferation of the stem cells, explains Zucchi. When grown in culture dishes, LA7 cells act just...Nitric oxide: Key to cardiovascular and pulmonary function and drug effectiveness
...onathan Stamler M.D. G-protein coupled receptors reside on the cell surface where they interact with all manner of stimuli, including circulating factors such as adrenaline, as well such diverse sensory signals as odorants and light. The activation of these receptors leads to the propagation of intracellu...Brain networks strengthened by closing ion channels
...vated cyclic nucleotide-gated channels (HCN), that reside on dendritic spines, the tiny protrusions on neurons that are specialized for receiving information. These channels can open when they are exposed to cAMP (cyclic adenosine monophosphate). When open, the information can no longer flow into the cell, ...Targeting tumors the natural way
.... Because target receptors on cancer cells usually reside on healthy cells, too - albeit in lower numbers - therapies aimed at these receptors are always expected to have debilitating side effects. That's why Kiessling's approach holds such promise. "What we've shown is that you don't need a receptor that's...Viral protein is an effective preventative against infection
...umoniae, arent transmitted at school. They already reside on the mucosal membranes in the nose, waiting for their chance to strike. When a child catches the flu, or another virus that causes an upper respiratory infection, the bacteria seize the opportunity and migrate to the middle ear, causing a secondary...Despite their heft, many dinosaurs had surprisingly tiny genomes
...to the bone cells called osteocytes. These cells reside in individual lacunae, small pockets inside bone tissue. This uniquely durable cellular housing allowed the scientists to look back in time at the size of 31 extinct species' genomes: By measuring lacunae in dinosaur and extinct bird specimens housed...News tips from the Journal of Neuroscience
... with compulsive behaviors. These 1 mm 3 hotspots reside in the shell of the nucleus accumbens and in the ventral pallidum and are reciprocally connected. To test the interaction between hotspots, the authors used a sucrose stimulus and tested rats for changes in Fos expression and for behavioral "liking" ......licles, and sebaceous (oil) glands. Because they reside in the skin, the cells are easily accessible. But purifying and characterizing them has taken years of research. "We had to learn enough about the properties of the different cells within the skin in order to come up with a strategy to isolate pure p...New mechanism for nutrient uptake discovered
...like protein structures called transporters, which reside at the surface of the cell's outer membrane. Each pore is capable of transporting nutrients individually, so we were really surprised to find that the pores simply can't act without stimulation from their neighbors." In earlier research the Carnegi...The code of codes -- Scientists discover parallel codes in genes
...genome. Many currently known regulatory sequences reside in non-protein-coding regions, but this may give scientists incentive to delve deeper into the protein-coding genes in order to solve life's mysteries....New medications, cancer diagnosis goals of UH engineers with $1M in grants
...g likely will follow. Because so many sensors can reside in a small area, hundreds even thousands of drug candidates can be screened at once, cutting down the time it takes to bring new drugs to market. In addition to testing the viability of potential drug candidates, the technology being developed by ...JCI table of contents: Feb. 1, 2007
...y inflammatory cells and destruction of cells that reside in the CNS, known as oligodendrocytes (ODCs). The soluble factor IFN-gamma has a detrimental effect on disease in patients with MS. However, studies using the mouse model of MS, known as EAE, indicate that IFN-gamma can also have a protective effect....... The job of MMPs is to cleave other proteins that reside in the space in between cells. Page-McCaw has previously identified a specific protein, called ninjurin, that gets cut by MMP. Now she is working out the interplay between MMPs and ninjurin, with the goal of characterizing this previously unknown pat...