Proteins' subtle 'backrub' motion could have important implications
..."We then went through each of those structures one residue at a time, looking for evidence of some sort of motion that extended beyond just a side chain spinning." Davis distinguished backrub motions by detecting movement of the first side chain atom attached to the backbone -- a shift that could only occur ...Emory scientists discover unique binding method for essential cellular protein ubiquitin
..."zinc finger domain," which consists of amino acid residue held together by a zinc ion. Using x-ray crystallography--a technique for imaging on the molecular level--she provided the first images showing that a ubiquitin chain binds to IsoT by inserting one end of a chain into a pocket on the zinc finger dom...Joint European strategy for industrial biotechnology
...d as a catalyst, and agricultural products and the residue of these are used as renewable raw materials. Research into industrial biotechnology is essential in order to make the chemical industry a sustainable sector. Moreover, it is viewed as a key technology for obtaining the Lisbon objectives. The Europea...JCI Table of Contents, June 15 2006
...d TNF-alpha induce the phosphorylation of a serine residue at position 345 on a component of NADPH oxidase. This event, which occurs via ERK1/2 and MAPK signaling pathways, "primes" the enzyme for action at sites of inflammation. The authors suggest that using drugs that inhibit this phosphorylation step mig...Neutrophils in rheumatoid arthritis: How to lessen inflammation but still fight infection
...d TNF-alpha induce the phosphorylation of a serine residue at position 345 on a component of NADPH oxidase. This event, which occurs via ERK1/2 and MAPK signaling pathways, "primes" the enzyme for action at sites of inflammation. The authors suggest that using drugs that inhibit this phosphorylation step mig...UCLA scientists strengthen case for life more than 3.8 billion years ago
...hich is approximately 4.5 billion years old. The residue of ancient life that the scientists believe they have found existed prior to the end of the "late heavy bombardment" of the Moon by large objects, a period which ended approximately 3.8 billion years ago, Harrison noted. "Life is tenacious, and it ...Mosquito spray increases toxicity of pyrethroids in creek, study finds
... sun for a day or two to let the pyrethrin and PBO residue degrade rather than send the runoff into the creeks....JCI table of contents: August 17, 2006
...ith angiotensin II, CaMKII phosphorylates a serine residue of a1H T-type Ca2+ channels, which leads to an increase in the intracellular Ca2+ concentration. Blocking this phosphorylation step in rats decreased the amount of aldosterone produced in response to angiotensin II. This study provides new insight in...Research aims for more efficiency in harvest and handling
...usly harvest corn and stover, while leaving enough residue on the ground to curb erosion and maintain tilth. "Our approach has been to never let the [corn stover] hit the ground," Shinners says. "You try to drive cost down by eliminating all of those extra field operations, and don't worry about drying it....Glue made from ethanol-production leftovers may be worth more than the fuel itself
...rs. He thinks that the large heap of fermentation residue from the ethanol-making process - what many people...ent," Weimer says. "We think that the fermentation residue may actually be more valuable than the ethanol. And it may mean that we can do without pretreatment.......ulation in an infested wheat field using the straw residue from a single mass-rearing cage. Mass-rearing of the parasitic wasps is only one of three or four approaches for sawfly management that are being pursued at MSU. The drought conditions of recent years have made the work more pressing, since drought...Insights into activity-dependent neuronal growth through RSRF-supported research
...result in phosphorylation of MeCP2 at a particular residue (S421) which, in turn, increases transcription of certain genes, including Bdnf, that are required for experience-dependent brain maturation. They further show that phosphorylation of MeCP2 at S421 is required for structural modifications of neurons ...Scientists convert modern enzyme into its hypothesized ancestor
... major difference being a change in one amino acid residue adjacent to the oxygen-binding site: The oxidase had an acidic residue capable of donating protons to the oxygen to form water while the desaturase did not. Based on this...News tips from the Journal of Neuroscience
...hors systematically substituted cysteines at every residue in transmembrane domains 6 and 7 of presenilin 1 and then determined their accessibility to a membrane-impermeable reagent that modifies cysteines. From the analysis, they concluded that the two transmembrane domains must form a water-filled, funnel-...Protein's tail may be flu virus's achilles heel
...," Tao said. "We found that a mutation in only one residue out of 30 was enough to prevent the NPs from coming together to form the building blocks for the columns, and without these columns the virus cannot make copies and infect other cells." Tao said the research also provides clues about NP's role in s...Midges send undeniable message -- planet is warming
... sediment just four inches (10 cm) of lake-bottom residue can represent nearly 100 years' worth of sedimentation, Porinchu said. "The amount of sediment that trickles out of the water column to the bottom of these lakes every year is so low because these lakes are at such high elevations few, if any, tre...Experts advise world policies to cope with causes, rising consequences of creeping desertification
...tch to clean cooking fuels instead of burning crop residue and animal dung so that soil stops losing valuable sources of nutrients badly needed now to forestall desertification and world hunger. He argues that a global effort to help restore badly-depleted soil resources in developing countries would help: ...Mayo researcher discovers target site for developing mosquito pesticides
...ated at the active site of the enzyme. This serine residue is present in both insects and mammals and therefo... and researchers elsewhere found that the cysteine residue acts as a hook that could tether a small molecule in the active site of an enzyme and permanently da...VBI research offers potential route to diabetes therapeutics
...and, more specifically, examined how changing each residue affected the enzyme's properties. The researchers concluded that it is possible to influence the activity of the enzyme from a site distinct from where the reaction takes place on the enzyme. The research appeared in the article, "Roles of Asp75, ......NAs have always been found with an extra guanylate residue at the 5' end of the tRNA molecule. The scientists, led by Kelly Williams of VBI, have shown that tRNAs carrying the amino acid histidine in the alphaproteobacteria Sinorhizobium meliloti and Caulobacter crescentus apparently lack the universal guany...