New use for a cell toxin found to inhibit survival proteins in cancer cells
...y. Cells with normal levels of Bcl-2 or Bcl-xL are resistant to 2-Methoxy antimycin. David M. Hockenbery, a member of the Hutchinson Centers Clinical Research Division and principal investigator for the study, and colleagues set up screening assays to look for small molecules or compounds that are selectively...Scientists find brown fat master switch
...ntrol in mice and overfeed them to see if they are resistant to becoming obese. "Brown fat is present in mice and in human infants, where it keeps them warm by dissipating food energy as heat, instead of storing it as white fat," said Spiegelman, senior author of the paper. "Human adults don't have much brow...Insulin sensitizer also serves as energy-conserving signal to the brain
...ore energy. That action, in turn, made the animals resistant to becoming obese even on a high-fat diet. Moreover, animals lacking adiponectin lost more fat after 12 hours of fasting than normal mice did. Blood levels of another fat hormone, leptin, are regulated inversely in relation to serum adiponectin lev...New way to target and kill antibiotic-resistant bacteria found
...ade, almost every type of bacteria has become more resistant to antibiotic treatment. These bugs cause deadly i...r traits such as drug resistance. Many highly-drug resistant bacteria rely on an enzyme, called DNA relaxase, to obtain and pass on their resistance genes. A mut...Scientists follow familiar TRAIL to new cancer therapy
...king c-Myc and a functional apoptotic pathway were resistant to TRAIL. In the current study, the researchers demonstrated that expression of c-Myc in TRAIL-resistant human colon cancer cells sensitized the cells to TRAIL, even when the cells had intrinsic apoptotic defects. The researchers observed that TRAIL ...Tiny tweezers and yeast help St. Jude show how cancer drug works
...n yeast cells, expressing a topoisomerase that was resistant to the drug. This was further evidence that camptothecins, such as topotecan, kill cells by preventing topoisomerase from uncoiling positive supercoils. ...First all-African produced genetically engineered maize is resistant to maize streak virus
...can seed company, PANNAR Pty Ltd, have developed a resistant variety of maize that they hope will help alleviat...king for more than a quarter century on developing resistant varieties of maize by selecting and crossing varieties with various degrees of resistance to the vir...Malaria-resistant mosquitoes battle disease with 'molecular warhead'
...researchers has discovered why some mosquitoes are resistant to malaria, a finding that may one day help fight ...researchers has discovered why some mosquitoes are resistant to malaria, a finding that may one day help fight a disease that afflicts and kills millions of peop...Researchers identify genetic mutation that may alter tumor cell proliferation
... proliferation and may play a role in making cells resistant to certain types of therapies. The findings are reported in an advance online publication (AOP) of the journal Nature. The PI3-Kinase/AKT pathway is among the most commonly activated cellular pathways in human cancers and members of this pathway ar...Manganese levels increase in scrapie-infected sheep before clinical symptoms develop
...istry. Although these sheep are considered to be resistant to scrapie, they do show some indications that scrapie challenge results in similar metabolic changes as occur in non-resistant sheep. Another interesting finding was that although levels of manganese were elevated, there were differences in the bl...M. D. Anderson team identifies new oncogene for brain cancer
...lly support and nourish neurons -- that are highly resistant to treatment. This makes IGFBP2 an important candidate for development of targeted therapy to treat gliomas, Zhang says. Gliomas kill about 13,000 people in the United States annually. The possibilities are not limited to brain cancer, Fuller n...... the gut and in the spleen of allergic and allergy resistant mice. He found that in the gut of susceptible mice, dendritic cells have stopped producing IL-12. This research was carried out in collaboration with the University of Siena. We have identified a molecule that is very important for the regulation...Extracting eggs from pre-pubertal cancer patients brings hope for future fertility
...individual eggs from the follicles, which are more resistant to the damage caused by extreme cold, offers a better chance of restoring fertility in adulthood. To their surprise, Dr. Revel and his team found eggs in the follicles of girls between 5 and 10 years old who had not reached puberty. We were able ...'Modular' leukemia drug shows promise in early testing
...means that this agent may benefit patients who are resistant to other CLL drugs, says co-author Natarajan Muthusamy, a research scientist with Ohio State's Comprehensive Cancer Center. It also suggests that it might work well in combination with other drugs, as well as alone....Support for chromosomal theory of cancer found in cancers' development of drug resistance
...taneous mutations can occur in cancer to make them resistant to more than one drug. "The fundamental problem ...normal cells," he said. "Why aren't we all getting resistant to any toxic drug we are exposed to" Why does it happen only in cancer cells" Why do cancer cells be...ORNL-led team wins DOE bioenergy center
...micellulose and lignin that makes plant cell walls resistant to the stress of weather, insects and disease. These sugars can then be processed into fuel. To date, no cost effective bioprocessing methods for cellulose-based bioenergy sources have been developed. The DOE Bioenergy Science Center will focus on ac...UGA scientists receive $20M in federal bioenergy initiative
...micellulose and lignin that makes plant cell walls resistant to the stress of weather, insects and disease. These sugars can then be processed into fuel. To date, no cost effective bioprocessing methods for cellulose-based bioenergy sources have been developed. The DOE Bioenergy Science Center will focus on ac...New amfAR research grants to optimize HIV treatment
...HIV reservoir. This reservoir contains HIV that is resistant to both antiretroviral therapy as well as the immune systems efforts to destroy it, and so constitutes the major barrier to curing HIV infection. Discovering the role of PD-1 in establishing and maintaining the reservoir may lead to new therapies des......s are not susceptible to it and have probably been resistant throughout millennia," said senior author Michael Emerman, Ph.D., a member of the Human Biology and Basic Sciences divisions at the Hutchinson Center. "However, we found that during primate evolution, this innate immunity to one virus may have made u...