Knocking out survival protein could aid leukemia treatment
...with an overabundance of the protein are also more resistant to anticancer drugs such as rituximab, which has revolutionized the treatment of certain chronic and acute leukemias. The study by researchers at the Ohio State University Comprehensive Cancer Center is published online in the journal Clinical Can...Freeze! Scientists film proteins at work by freezing them at different states
...proteins that get excited by light and are in very resistant crystals....Discoveries thrust cancer-initiating stem cells into a larger role in cancer biology and treatment
...ome targets of interest in the treatment of tumors resistant to the drug Herceptin. "We now believe that our ...ty will then initiate and maintain tumors that are resistant to current therapies. The two genes appear to influence stem cell self-renewal by controlling two ...Researchers identify key gene that may be a marker of breast cancer metastasis
...arch focused on breast cancer cells that had grown resistant to a class of anti-hormone drugs called aromatase inhibitors. AIs shut down an enzyme, aromatase, that lets the body produce estrogen outside the ovaries. These drugs represent one of the newest, most effective forms of hormone therapy for postmeno...Other highlights from the April 18 Journal of the National Cancer Institute
...2 gene can be treated with lapatinib, but they are resistant to another drug known as trastuzumab. HER2 is a...ognosis. Many breast cancers that express HER2 are resistant to the HER2 antibody trastuzumab, a drug often used to treat HER2-positive breast cancer. Some are r...Investigational cancer drug targets critical proteins
...ones are highly expressed in human cancer and seem resistant to radiation therapy and chemotherapy, according to Dr. Bhalla. ...Research on grey mold offers possible breakthrough in tomato cultivation
... efficient methods whereby tomato varieties can be resistant to grey mould. The leading company De Ruiter Seeds... started off with wild tomato accessions that were resistant to grey mould. When crossing the resistant wild tomato Solanum habrochaites LYC4 with the susceptibl...Antibiotic stress, genetic response and altered permeability of E. coli
...e bacteria such as Escherichia coli are frequently resistant to two or more antibiotics (multi-drug resistant). Because introduction of new antibiotics will not eliminate the problem of multi-drug resistance (mdr), mdr type infections constitute a major health threat, especially to patients that acquire such ...Little lifesavers -- Nanoparticles improve delivery of medicines and diagnostics
...rade them. The team made their particles even more resistant to early degradation by attaching hydrophobic substances, including vitamin E, to the medicines and imaging agents before incorporating them into the particles. Further studies of the controlled release technique currently are under way. Prud'homme...Disease can be our ally, not just our enemy, says new book by UCR evolutionary biologist
...ys evolving back at us, so a copy of even the most resistant set of genes will become outdated and useless in a... of pneumonia, meningitis, and ear infections, are resistant to penicillin. Tuberculosis, syphilis, typhoid, gonorrhea all have antibiotic-resistant strains in...Researcher examines polymers created with poultry feathers
..., be more aesthetically pleasing, and become water resistant and stronger for increased longevity. ...Removing a hydrogen fuel-cell roadblock
...g alloy shiny, ductile, high melting, and totally resistant to aqua regia (a mixture of nitric and hydrochloric acids that dissolves gold or platinum)." Russell added that the willingness of the DOE to fund such a program is indicative of the commitment to develop alternative energy sources. "Research fun...UBC researchers find new superbug weapon for near-empty antibiotics arsenal
...tly. That means it's unlikely bacteria will become resistant to it." The team found that a peptide, or chain ...oking at a crisis in 10 years as most bugs will be resistant to most antibiotics. There's an urgent need to develop new tools," says Brett Finlay, a UBC microbio...Meat and two neutrons -- the key to a longer life
...al isotopes builds bodily components that are more resistant to the processes of ageing. The concept has been d...hought to produce bodily constituents and DNA more resistant to detrimental processes, like free radical attack. The isotopes replace atoms in susceptible bonds...Could estriol be the elixir for MS?
...attack the brain, as well as making the brain more resistant to damage if any immune cells do make it through. "It's a two-pronged approach an anti-inflammatory prong to reduce the attacks, but also a neuroprotective prong to make the brain suffer less damage in case of an attack," said Voskuhl. In all, s...Jefferson scientists uncover gene mutation that cuts colon polyps, may suppress cancer
...r or lower, and can mean a person is more prone or resistant to developing polyps and tumors. In earlier work, the husband and wife team had identified the general region on the chromosome for the mutation. Now, weve identified the gene and its very important it encodes a subunit of the ATP synthase protei...Researchers uncover protection mechanism of radiation-resistant bacterium
... In a 2004 study, Daly and colleagues found that resistant and sensitive bacterial cells had significantly di...llowing irradiation. The team showed that the most resistant bacterial species contained approximately 300 times more manganese and three times less iron than th...Will the plague pathogen become resistant to antibiotics?
.... "When we identified the first Y. pestis strain resistant to multiple antibiotics, we warned that if this type of strain spreads or emerges again, it would pose a serious health problem" says co-author Elisabeth Carniel, head of the Yersinia Research Unit at the Institut Pasteur in Paris. "The discovery tha...Why is long-term therapy required to cure tuberculosis?
Understanding why other bacteria become resistant to antibiotics could hold the key to understanding...a, the dormant state of TB is thought to render it resistant to treatment. But the authors now challenge this traditional view. In the light of data on treati...One small step for Deinococcus or one giant leap for radiation biology?
...ll cause high levels of protein damage compared to resistant cells exposed to the same dose. This new model of ... damaged. In contrast, repair enzymes in extremely resistant cells survive and function with great efficiency after irradiation because they are protected, speci...