Trojan horse strategy defeats drug-resistant bacteria
...inical Investigation. Bacteria are increasingly resistant to antibiotics, and existing drugs work poorly aga...aeruginosa from cystic fibrosis patients that were resistant to multiple antibiotics. In mice, gallium treatment blocked both chronic and acute infections caused...Gallium: A new antibacterial agent?
...eded because more and more bacteria are antibiotic resistant and because antibiotics are not effective at eradi... growth of Pseudomonas aeruginonsa; even multidrug resistant strains of P. aeruginonsa isolated from individuals with cystic fibrosis. Ga also prevented P. aerug...JCI table of contents: March 15, 2007
...eded because more and more bacteria are antibiotic resistant and because antibiotics are not effective at eradi... growth of Pseudomonas aeruginonsa; even multidrug resistant strains of P. aeruginonsa isolated from individuals with cystic fibrosis. Ga also prevented P. aerug...UNC scientists discover cellular 'SOS' signal in response to UV skin damage
..."This protective response may make some cells more resistant to certain types of cancer therapies which work by inducing the cancer cell to die. If the cell, even if it is a cancer cell, is given this additional time to recover from treatment, it may be able to survive it, much to the detriment of the patient...500,000 years of climate history stored year by year
...sts the ravages of time. The material is extremely resistant to environmental influences and even withstands strong acids or bases, Professor Litt explains. Using hydrofluoric acid or potassium hydroxide he dissolves the pollen grains from the sediment samples; the grains prove to be completely impervious to s...New cell type identified in cancer development
...usly tricky to isolate and describe. They are also resistant to virtually any kind of treatment, and some scientists believe they are the reason cancer recurs. Until now, no one has known how they arise. But a team of scientists, led by Dr. Jian-Xin Gao, a researcher in the department of pathology at Ohio St......ise in the incidence of new strains of TB that are resistant to traditional antibiotics. As a result, the World...quantities to kill the bug completely; this is how resistant strains develop and these regions have become huge breeding grounds for these super strains." Fund...Bacterial walls come tumbling down
... as methicillin-resistant Staphylococcus aureus is resistant to several common antibiotics, including penicillin and amoxicillin, and is a great cause for concern among hospital infectious disease staff. Postdoctoral fellow Andrew Lovering, who is first author on the paper, hopes the group's three-dimensional ...Breakthrough vaccine to treat chemo-resistant ovarian cancer
...ly stages, is a very complex disease that is often resistant to chemotherapy. Cancer Treatment Centers of America will offer this new treatment to patients whose cancer has recurred after chemotherapy. "To win the fight against cancer, it is absolutely vital we do everything we can to make innovative new tr...Scientists find genes involved in the battle between Hessian flies and wheat
... can't establish a feeding site on plants that are resistant to the larvae. "The focus of our work is to try .... The toxic oxygen compound defense mechanism in resistant plants stresses the larvae, which then fight back, he said. This is confirmed by the Hessian fly lar...Photodynamic therapy as alternative therapy for periodontal diseases may be beneficial
...ness, but also may lead to the development of drug resistant organisms. Our Academy supports future research to further define the application of PDT as a means to treat periodontal disease."...Insulin -- in need of some restraint?
...igh a level for too long, the body becomes insulin resistant and blood sugar and certain blood lipids gradually creep up, which can cause progressive damage to multiple organs." Urocortin 3 is the second urocortin peptide that this laboratory has found to restrain insulin production or action. In a study pub...UA researchers identify new adherence factor, Pili, produced by tuberculosis
...tions, as well as with the emergence of multi-drug resistant strains of M. tuberculosis. Such strains constitute a very serious public health problem because they cannot be treated with any of the most commonly used anti-tuberculosis antibiotics, resulting in high mortality and rates of transmission," said Dr....JCI table of contents -- March 1, 2007
... the lungs (known as alveolar macrophages) of mice resistant to lung damage caused by the oxidant ozone expressed more of a protein known as MARCO than the alveolar macrophages of mice susceptible to ozone-induced lung damage. Consistent with a role for MARCO in protection from oxidant-induced lung damage, mic...Cells in the lung clear the air to prevent lung damage
... the lungs (known as alveolar macrophages) of mice resistant to lung damage caused by the oxidant ozone expressed more of a protein known as MARCO than the alveolar macrophages of mice susceptible to ozone-induced lung damage. Consistent with a role for MARCO in protection from oxidant-induced lung damage, mic...Joslin study reveals how a specific fat type can protect against weight gain and diabetes
...fat diet than the B6 mouse and has been considered resistant to dietary induced obesity and glucose intolerance. In the new study, Dr. Kahn and his colleagues showed that this difference is due to the higher basal energy expenditure in the 129 mouse. When searching for the source of the energy expenditure, the...New UD technology removes viruses from drinking water
... are far smaller than bacteria, highly mobile, and resistant to chlorination, which is the dominant disinfection method used in the United States, according to the researchers. Of all the inhabitants of the microbial world, viruses are the smallest--as tiny as 10 nanometers. According to the American Society...E. coli bacteria migrating between humans, chimps in Ugandan park
...ome of the E. coli strains migrating to chimps are resistant to antibiotics used by humans in Uganda. Their s...inding that humans had transferred some antibiotic resistant strains to chimps "was the smoking gun," Goldberg said. More than 81 percent of the humans and 4.4 p...JCI table of contents -- February 22, 2006
...astasize to distant organs, and are usually highly resistant to chemotherapy and radiation. Understanding the molecular differences between radial and vertical growth melanomas might provide new targets for the development of drugs to treat individuals with advanced stage melanoma. In a study that appears on....... The bacteria Vibrio campbellii are antibiotic resistant and cause significant loss in the fish farming industry (aquaculture) as an outbreak cannot be treated with antibiotics. Adding PHB to the culture water significantly decreased the number of brine shrimp which were killed by Vibrio campbellii. The sh...