Protein identified that regulates effectiveness of Taxol chemotherapy in breast cancer
...ights into why some breast cancer cells can become resistant to therapeutic drugs." Additionally, the study i...t phosphorylated, breast cancer cells appear to be resistant to Taxol treatment, the researchers conclude. "Thus, this study opens an area of investigation in ou...Gene profiling predicts resistance to breast cancer drug Herceptin
...und markers that identified breast cancer subtypes resistant to Herceptin, the primary treatment for HER2-posit...id not express IGF-1R. They also discovered that resistant tumors continue to over-express the HER2 growth factor protein -- an important finding given that ma...Novel test identifies lymphoma patients likely to respond to new therapy
...d by BPI while lymphomas without the signature are resistant to the therapy. Suitable lymphoma patientsthose whose tumor cells exhibit this BCL6 signature --will now have access to a potent and specific therapy that is unlikely to cause the side effects associated with chemotherapy drugs," says Dr. Melnick.......to target these stem cells: they are intrinsically resistant to chemotherapy. Polycomb proteins have emerged ...g instead of maturing into specific tissues. Some resistant cancer cells dont listen to the stop signal any more, he explains. That stop sign is delivered by th...Problem forgetting may be a natural mechanism gone awry
...est memory scores throughout their lives were more resistant to the interference. However, aged animals with impaired memories displayed what was termed as robust long-term depression. Going back to the phone call example, not only did the rest of the room get quieter, the callers did, too. The assumption i...IDIBAPS participates in European Network on antibiotic resistances and hospital infections
...oup of IDIBAPS. The appearance and spread of resistant bacteria is one of the most alarming events of the...d the appearance and to contain spreading of these resistant bacteria in European hospitals, especially in the units more exposed to this problem (intensive care...Orbiter provides new hints of past groundwater flows on Mars
... the rock, they say. The cemented rock proved more resistant to wind erosion than other features on the canyon walls and floor. It now serves as an exposed record of hydrological activity and offers a promising site to search for evidence of habitable niches in the Martian past. Chris H. Okubo, the principal...JCI table of contents: February 15, 2006
...th a global PPAR-gamma defect are severely insulin resistant and have less fat than normal mice, although the latter is offset by an increase in the size of all the internal organs. These changes were associated with a decrease in blood pressure (hypotension), which is surprising given that PPAR-gammastimulati...Successful development of prototype assays
...ments that have been successfully engineered to be resistant to β-Lactamase inhibitors as announced in October 2006. The technology represents a potentially great advance in medical and veterinary diagnostics. Reduced diagnostic test processing times down to as little as 10 minutes are possible, down fr...Super-thin membrane, 50 atoms thick, sorts individual molecules
...ow they stand up to regular wear and tear, and how resistant they are to clogging, which is a chief problem with conventional filters....Harvard team creates spray drying technique for TB vaccine
... the increasing incidence of tuberculosis and drug resistant disease in developing countries due to HIV/AIDS, t...With the emergence of multidrug and extremely drug resistant TB, we hope this breakthrough is one more step to help us develop a stable vaccine to stem the tide ...Oxidative stress stimulates p38 MAPK-mediated tumor suppression
...poptosis, whereas the cells lacking p38-alpha were resistant to ROS-induced apoptosis. The researchers point out that this finding may have clinical significance, as they observed that increased ROS levels were also linked to tumorigenic potential in several human cancer cell lines that were examined. The a...Female Antarctic seals give cold shoulder to local males
...re genetically diverse individuals tend to be more resistant to disease, carry fewer parasites, and in the case of males, are more aggressive and father more offspring. It had long been assumed that the females were passive, simply mating with their nearest male. However, using paternity tests, the scientists...Exercise pivotal in preventing and fighting type II diabetes
...id. The study, "Contraction of insulin resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism," will be published in the American Journal of Physiology-Cell....Scientists identify pancreatic cancer stem cells
...d to take on the qualities of stem cells. They are resistant to traditional therapy designed for cells that rapidly turn over because stem cells don't, according to some researchers. Thus, they remain after tumors shrink and may be responsible for cancer recurrence and metastasis. This study confirms at leas...JCI table of contents: Feb. 1, 2007
...p21Waf1/Cip1/Sdi1 (p21) is required for HSCs to be resistant to infection with HIV-1. David Scadden and colleagues showed that HSCs in which expression of p21 was decreased were more susceptible to infection with HIV-1 than cells expressing normal levels of p21. Further analysis showed that p21 did not inhibi...Salmonella survives better in stomach due to altered DNA
...his type, Salmonella serovar Typhimurium DT104, is resistant to at least five different antibiotics. Dutch researcher Armand Hermans found new genetic information in DNA of DT104 that might be involved in its survival and infection mechanism. This genetic information might also be involved in the increase in t...Weight-loss supplement shows good and bad traits
...ue to the weight gain. In turn, the rats were less resistant to insulin. "Many people take CLA as a supplemen...t lost fat in the liver. The mice also became less resistant to insulin. "When we took CLA away, we lost that suppressive effect on body fat, but we were actua...New approach could lower antibiotic requirements by 50 times
...s had slowly created a host of infections that are resistant to antibiotics. MRSA (Methicillin-resistant Staphylococcus aureus) for example is rapidly spreading through hospitals, affecting more than 8,000 people in the UK every year. MRSA infection can lead to septic shock and death....Scripps Research study reveals new function of protein kinase pathway in tumor suppression
...no senescent cells. The PRAK knockout animals were resistant to ras-induced senescence but prone to tumor induction, which led us to the happy conclusion that PRAK and the senescence response mediated by PRAK has a tumor-suppressing function in vivo. The knockout mice were more vulnerable to tumor induction be...