Estrogen interferes with immune surveillance in breast cancer
...tities of the granzyme inhibitor and become highly resistant to immune attack. The researchers were able to show that estrogen's effect on PI-9 production was the sole mechanism by which estrogen interfered with the natural killer cells' ability to kill off breast cancer cells. They did so by blocking PI-9 p...Detaining patients is justified to contain deadly TB strain in South Africa say experts
...rced isolation and confinement of extensively drug resistant tuberculosis (XDR-TB) and multiple drug resistant tuberculosis (MDR-TB) infected individuals may be a proportionate response in defined situations giv...Microwave oven can sterilize sponges, scrub pads
...bacterial spores, Bacillus cereus spores are quite resistant to radiation, heat and toxic chemicals, and they are notoriously difficult to kill. The UF researchers used the spores as surrogates for cysts and oocysts of disease-causing parasitic protozoa such as Giardia, the infectious stage of the protozoa. Th...ACS News Service Weekly PressPac -- Jan. 17, 2007
...mechanism that renders about half of human cancers resistant to chemotherapy. Such findings have stirred new interest in understanding silent polymorphism, and determining its precise role in human health, the article points out. ARTICLE #5 EMBARGOED FOR 9 A.M., EASTERN TIME, JAN. 22, 2007 "Silent No Longer:...UCLA and NYU microbiologists crack genome of a parasite that causes a common STD
...es, and the emergence of parasite strains that are resistant to these drugs is on the rise. There is a clear need to develop additional effective drugs, Johnson said. The T. vaginalis genome project began in 2002 and was funded by the National Institute of Allergy and Infectious Diseases, part of the Nationa...Researchers develop new strategy for the treatment of CML
...espite initial success, patients eventually become resistant to imatinib mesylate. According to Steven Grant...ls expressing many of the mutations that make them resistant to the latter agent. Dasatinib also inhibits another important survival protein known as Src. Howeve...Researchers discover surprising drug that blocks malaria
... rapidly changes its molecular structure to become resistant to those drugs. It would be difficult, however, for the malaria parasite to develop resistance to a drug that acts on a person's red blood cells as the blood pressure medication does, Haldar said. When Haldar and her colleagues tested propranolol i...New antibacterials being developed to tackle MRSA superbug
...ureus, or MRSA, is a form of the bacterium that is resistant to the drug methicillin and a number of other antibiotics and tends to be more difficult to treat. "The so-called superbug MRSA is fast becoming untreatable with the currently available antibiotics," says Dr Ted Bianco, Director of Technology Transf...Scientists sequence genome of parasite responsible for common sexually transmitted infection
...s to why the parasite has become increasingly drug resistant and suggesting possible pathways for new treatment...d identified possible ways the parasite may become resistant to these medications. Understanding how T. vaginalis causes infection and developing methods to prev...TIGR researchers reveal tricks of common sexually transmitted infection
...e, Trichomonas vaginalis, is becoming increasingly resistant to this drug, making development of new medicines a high priority. Infected men frequently have no symptoms, and sometimes women are symptom-free as well. Thus diagnosis and treatment can be difficult. Symptoms include a frothy yellow-green dischar...Researchers urge monitoring of bone health during chemotherapy
...osteoporosis agent that inhibits osteoclasts, were resistant to the effects of G-CSF on bone tumor growth. Weilbaecher is currently investigating bisphosphonates as a means to prevent tumor metastasis to bone in breast cancer patients. "We used G-CSF as a tool to understand the implications for tumor growth w...Stealth technology maintains fitness after sex
...bacterial genes, such as those that make pathogens resistant to antibiotics. However, the plasmid comes at a ...istance plasmid they have described in Salmonella, resistant bacteria are likely to survive and the resistance genes to persist even if antibiotic therapy is sto...Wheat can fatally starve insect predators
...ure, known as a chitin. When the larvae attack a resistant plant, the plant's lectin production quickly incre...in. However, the researchers believe that plants resistant to Hessian fly invasions may make several strains of lectins in response to virulent larvae, William...NSF funds biofertilizer research at Rutgers-Camden
...ient in the uptake of specific nutrients, and more resistant against soil-borne pathogens, interest in using these fungi as "biofertilizers" or "bioprotectors" is increasing. By promoting the proliferation of mycorrhizal fungi through diminished fertilizer input, farmers would make more efficient use of the n...Genetically altered cells may help artificial skin fight infection
...enetically altered cells containing HBD4 were more resistant to microbial infections than the unaltered cells. "If it proves effective in additional testing," Supp predicts, "this type of gene therapy could be a promising alternative infection control method for burn wounds." Researchers hope to begin test...New HIV test may predict drug resistance
...ent by predicting if a patient is likely to become resistant to a particular HIV drug, said one of its develope...strains take on new properties that make them more resistant to the drugs used in antiretroviral therapy, the primary means of treatment for HIV infection. Duri...MGH Cancer Center researchers find new gene associated with Wilms tumor
...ise slowly from the organ's tubules and are highly resistant to current chemotherapy drugs, but pediatric kidney tumors arise in the early stem cells of the kidney's filtering apparatus and are highly responsive to chemotherapy. Following up on these findings should help us better understand this tumor and ma...News tips from ACS Chemical Biology
...y it due to its notorious talent for mutating into resistant strains. Himmel and Arnold report the crystal structure of HIV-1 reverse transcriptase complexed with an inhibitor of RNase H activity, suggesting intriguing new strategies for hitting HIV where it could really hurt. Based on a bacterial quorum se...Other highlights in the December 20 JNCI
...cells that gives rise to a tumor may be relatively resistant to radiotherapy and may even increase when given multiple treatments of radiation, a new study shows. In the last several years, researchers have discovered a small population of so-called cancer-initiating cells (also called cancer stem cells) in...First Laos bacteraemia study highlights need for local knowledge
...sia, the researchers found few cases of multi-drug resistant typhoid. Use of fluoroquinolone antibiotics in oth...rent situation in Vietnam where typhoid is usually resistant to commonly used, inexpensive antibiotics," says Dr Rattanaphone Phetsouvanh of the Mahosot Hospital...