NIH gives $8M to University of Pittsburgh School of Medicine for myositis research
...t rheumatoid arthritis patients with an inadequate response to anti-TNF (tumor necrosis factor) agents. In this study, rituximab is considered to be experimental because it is not FDA approved for the treatment of dermatomyositis or polymyositis. The study doctors believe that the symptoms of myositis are rel...Study begins to reveal clues to the cause and progression of sepsis
...develop sepsis, a result of the bodys inflammatory response to an infection, which can lead to organ failure a...the complexity and variability of the inflammatory response to sepsis. To gain a better understanding into the mechanisms behind the condition, the researchers ...Circadian clock controls plant growth hormone
...he production of auxin through to the final growth response showed some regulation by the clock. Covington a...e plants are preparing for daylight. A circadian response to auxin was actually observed in 1937 but then forgotten for 70 years, Harmer said. The researchers...JCI table of contents: Aug. 9, 2007
... apoptosis activated by the sustained inflammatory response the intrinsic apoptotic pathway of cell death. The extrinsic apoptotic pathway of cell death proceeded unchecked. These data led the authors to suggest that the extent of cardiomyocyte apoptosis is a critical factor in determining whether or not adv...Brain blood flow gives clues to treating depression
...depressant drugs failed. Interestingly, patients response to two different classes of antidepressant medicin...or the development of depression and for mediating response to its treatment, he added. Additional research could examine whether its possible to use functional...Study finds gender differences in renal and other genes contributing to blood pressure
...ender may affect vascular physiology and the bodys response to some types of blood pressure medications. Although gender is usually accounted for in association studies, newer research has focused on identifying autosomal (not on the X or Y chromosomes) genes that contribute differentially to complex traits ...Sugar and spice and everything nice: Health differences in newborn girls and boys
...to the research team, the results suggest that the response of the newborn female heart (i.e., myocardium) to ischemia may increase its susceptibility to injury during ischemia and offer a potential explanation for the poorer clinical outcomes found in infant females following cardiac surgery. Study 2: L...Inflammation may cause preterm labor and fetal deaths
...s as a possible link in producing the inflammatory response that is believed to have brought about the fetal d...ce deficient in TLR4 lacked the necro-inflammatory response to bacteria and produced healthy pups. This discovery led Han and her colleagues to attempt to bloc...What we can learn from the biggest extinction in the history of Earth
...l Nio years, corals bleach. This type of immediate response to environmental change is hard to track in the geologic record. "We hope to reconcile the short-term processes we observe operating in the modern world with the very long time scales seen in the geologic record," said Seth Finnegan, a postdoctoral...News tips from the Journal of Neuroscience
...magnitude, discriminable level steps, and temporal response patterns. These parameters generally were optimal at rostral and slightly ventral ICC stimulation sites. At least two functional regions emerged, one caudal--dorsal and one rostral--ventral, which will require consideration in designing implants. ...Preclinical study links gene to brain aneurysm formation
...n important role in remodeling of blood vessels in response to changes in blood flow. When a vessel experiences increased blood flow, it attempts to reduce the shear stress to even levels by enlarging its luminal caliber through a process known as remodeling. This involves reabsorbing the inner layers of th...Secret life of elephant seals not secret anymore!
...ity of St Andrews in the UK. Until recently, the response of large marine predators to environmental variability has been almost impossible to observe directly. Sensors were deployed on 85 elephant seals from key colonies in January and February 2003 and lasted throughout most of the Antarctic winter se......wisdom that even harmless bacteria and the immune response they provoke suck up the energy of the host organ...the organism increases with age. The innate immune response to bacteria is similar in flies and humans, and it loses strength with age in both species. The st...In limiting life span, study finds booming bacteria innocent
... accumulating so much bacteria and a robust immune response to that bacteria, its not limiting how long the fl...umber of bacteria and mount a strong innate immune response against them without cutting their 65-day lives any shorter. There has been some thinking in gener...High-intensity ultrasound may launch attack on cancer, wherever it lurks
...mmune system, Zhong said. For an anti-tumor immune response to be effective, it may need to recognize not only... delivered to the animals tumors sparked an immune response twice as strong as did thermal HIFU, presumably by releasing a much more diverse range of danger sig...Cornell scientists link E. coli bacteria to Crohn's disease
...terial characteristics that drive the inflammatory response have remained elusive. Researchers at Cornell examined possible causes for the disease in patients with Crohns restricted to the ileum and the colon versus healthy individuals. Given that only about 20 percent of fecal bacteria can be cultured, our...Penn researchers discover how key protein stops inflammation
...lled Bcl-3 helps to control the bodys inflammation response to infection by interfering a critical biochemical...he DNA region coding for inflammation, halting the response to infection, explains Chen. Without Bcl-3, Chen says p50 cannot stop the inflammation response, but...Gene variant is associated with brain anatomy, clinical course of ADHD
...components on a disease pathway] for ADHD, such as response inhibition and working memory....How cells change the pace of their steps
...ells of all higher, or eukaryotic, species move in response to external stimuli. This movement is made possibl... types in the body can move at different speeds in response to many different stimuli, and while our collaborative study didnt look at these possibilities per s...UC experts detail new standard for cleaner transportation fuels
... and the new fuels that will come on the market in response to the low carbon fuel standard will be an important part of that change, said Farrell. One of the key roles for the state agencies will be ensuring that the competition among the different fuels results in real carbon emission reductions, more cons...