Study begins to reveal clues to the cause and progression of sepsis
...Health embarked on the Framingham Heart Study, the results of which have influenced everything we know about the prevention and treatment of cardiovascular disease. With our study, were hoping to do the same for sepsis, providing a greater understanding of the disease on which future treatment and prevention...Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
...quisition of the mutations identified in our study results in the accumulation of malignant plasma cells beyo...ogical control of the bone marrow compartment. Our results suggest a mechanism by which MM cells can overcome these limitations through acquisition of mutation...Pollution causes 40 percent of deaths worldwide, study finds
...d water. Increased soil erosion worldwide not only results in more soil being blown but spreading of disease microbes and various toxins. At the same time, more microbes are becoming increasingly drug-resistant. And global warming, together with changes in biological diversity, influence parasite evolution...Which came first, the moth or the cactus?
...ual species and of whole networks of species." The results suggest that the structures of mutualistic communities compliment those of predator-prey food webs, a finding that presents the tantalizing possibility of developing an overarching scheme that incorporates elements of both....Bursts of waves drive immune system 'soldiers' toward invaders
...wn destruction, even while it is progressing. This results in a wave that moves undiminished because of the self-activation, and in one direction, because of the inhibition it leaves in its wake," he says. The scientists observed the Hem-1 activation of actin assembly and actin's inhibition of Hem-1 accum...Features of replication suggest viruses have common themes, vulnerabilities
...air where it can safely replicate its genes. The results provide strong evidence that at least some of the machinery four of the seven distinct classes of known viruses use to reproduce have common attributes. Such a discovery is important because it reveals a common viral theme that may be vulnerable to d...Doernbecher Children's Hospital scientist earns coveted Javits award
...od flowto the brain. The loss of these oligo-cells results in failure to makethe myelin required for normal brain function. Progress in preventing this brain injury has been slow, Back says,because of the lack of animal models to test therapies for the complexforms of brain injury that occur in human survi...Gene regulation, not just genes, is what sets humans apart
...-wide analysis of coding regions. To be sure their results would be robust, they focused on just the most reliably accurate published DNA sequences in common between the three animals, discarding two-thirds of the genome to ensure accuracy. With only three species, we had to be very stringent about quality, ...Risk of common vaginal infection linked to preterm birth appears higher for blacks
...owed an influence on BV risk, Dr. Simhan said. Our results showed that when one partner is black whether male or female risk of BV goes up two-fold. BV infection is commonly treated with a range of antibiotics. However, in some cases treatment fails and infections become resistant. Even women whose infec...UK scientists working to help cut ID theft
...scientists are well respected in the field. The results that emerge from Biotesting Europe will provide a clear direction for the future development of shared resources for biometric testing....Does the desire to consume alcohol and tobacco come from our genetic makeup?
...ex-specific loci inside some of these areas. The results are based on the study entitled, Genome-wide Scan for Genomic Determinants of Alcohol and Tobacco Use in French Canadian Families. It was conducted by Majid Nikpay, O. Seda, Johanne Tremblay and Pavel Hamet, of the Research Centre CHUM, University of...Abnormal fat metabolism underlies heart problems in diabetic patients
...e days after diabetes was induced in mice." "These results suggest that cardiolipin alterations underlie heart dysfunction in diabetic heart disease and may be a useful biomarker for diagnosing cardiovascular disease in diabetes," Gross says. "Measuring alterations may be a way to tell the severity of heart ...Tropical insects 'go the distance' to inform rainforest conservation
...m that conducted this groundbreaking research, the results of which are described in the Aug.ust 9 online issue of the journal Nature. The group included scientists from Australia, the Czech Republic, the United Kingdom, New Guinea and the United States. Tropical rain forests are home to a rich diversity o...Climate change and permafrost thaw alter greenhouse gas emissions in northern wetlands
...peat, have remained big questions for us. Their results were surprising. Turetsky and her colleagues studied areas affected by permafrost degradation across a large region of Canada. They initially expected to find that the melting ice would (trigger a release of greenhouse gases to the atmosphere, as...OHSU turns mouse into factory for human liver cells
...gineered and bred to grow human liver cells. Early results since 2004 showed it could be done, but the mice were difficult to breed, the time window for transplanting human liver cells into the mice was narrow, and the mouse liver, despite efforts to make the animal immunodeficient, often rejected the human ...Genetic variation helps to understand predisposition to schizophrenia
...gene to be overexpressed in the human brain. These results may provide a new way to design better drugs to tr...enetic variation in this promoter, Law says. These results will probably help us understand how DNA variations affect the function of this gene and lead to sym...Antioxidant overload may underlie a heritable human disease
...der in humans, according to the researchers. The results found in the heart suggest that reductive stress might underlie other diseases, as well. Our findings open up a whole new line of investigation in protein aggregation diseases, including neurodegenerative diseases such as Alzheimers and Huntingtons d...A study by the MUHC and McGill University opens a new door to understanding cancer
...e growth factor become much more pronounced, which results in an unrestrained proliferation of cells that can become a cancer. In the long term, this may serve as a basis for us to find ways to intervene in this chain reaction and discover a treatment adds Dr. Gehring. This new information about ubiquitin...Research shows skeleton to be endocrine organ
...ic Sciences, and senior author of the paper. These results uncover an important aspect of endocrinology that was unappreciated until now. Karsenty and his colleagues had previously shown that leptin, a hormone released by fat cells, acts upon and ultimately controls bone mass. They reasoned that bones must......fails to accurately segregate the chromosomes this results in diseases like Down syndrome and infertility. It is therefore very important that we now understand how this crucial division at the beginning of life is orchestrated....