Study provides first look at the 'birth' of a retina cell
...ls of specific diseases, such as macular and other retinal degenerations. Gene profiling of rods and cones in disease models at various stages of pathogenesis could help scientists identify molecular targets for drug treatment. Swaroop is hopeful that his research group can use the fluorescent protein to il...Factor isolated that regenerates nerve fibers
... axon regeneration. When oncomodulin was added to retinal nerve cells in a Petri dish, with known growth-promoting factors already present, axon growth nearly doubled. No other growth factor was as potent. In live rats with optic-nerve injury, oncomodulin released from tiny sustained-release capsules increa...Neural stem cell gene plays crucial role in eye development
...ypes in the nervous system. In the developing eye, retinal neural stem cells differentiate to form the neuron...at, in mice, disruption of the SOX2 gene in neural retinal stem cells leads to a kind of abnormal development of the eye called microphtalmia, or small eye. Ap...Full year of treatment helps infants and children with toxoplasmosis
...e impairment of vision, 64 percent have had no new retinal lesions since beginning treatment. Unfortunately 1...decrease between evaluations. One developed a new retinal lesion. "The majority of the children in our cohort are entering adolescence without experiencing re...Schepens scientists are first to discover angiogenesis switch inside blood vessel cells
...can also nourish cancer tumors and damage delicate retinal tissues when uncontrolled. The angiogenic process is triggered by what the body perceives as a need for additional blood flow. In the case of disease, it is a mistaken need. In response, the body sends growth factors (such as VEGF) to blood vessels...Gene therapy for chicken model of childhood blindness
...d LCA1 which is caused by defects in a gene called retinal guanylate cyclase (GUCY2D). Defects in the gene leave the light sensitive photoreceptors in the eye unable to respond to light, and so cause blindness. Loss of function of these receptor cells leads to their degeneration and eventually breakdown of t...UF scientists restore sight to chickens with blinding disease
...ring therapy for children who suffer from blinding retinal diseases." Like people, chickens possess color vis...ve restored sight and slowed degeneration, but the retinal cells still degenerate. But Semple-Rowland thinks the time necessary to turn these research results ...Harvard Medical signs agreement with Merck to develop potential therapy for macular degeneration
...f the light gathering components of the eye called retinal photoreceptors. The macula is the portion of the r... absorption. Retinal photoreceptors and associated retinal pigment epithelial cells repair these altered chromophores, but the photochemically modified chromop...Bone marrow may restore cells lost in vision diseases
...ef that a cell layer vital for eyesight called the retinal pigment epithelium, or RPE, is a nonrenewable reso...place cells lost to injury or disease. "In people, retinal pigment epithelium can become damaged with age," said Jeffrey Harris, a graduate student in the depa...Meconium: Baby's first stool may provide clues to fetal alcohol exposure
...eicosanoids, while docosahexanoic acid is used for retinal and brain development in the fetus and infant. We propose that when the fetus is exposed to alcohol arachidonic and docosahexanoic acids may become unavailable to the fetus for its developmental needs, particularly brain development. This could re...News tips from the Journal of Neuroscience
...r 7 months. Untreated rats lost up to 20% of their retinal ganglion cells, whereas treated rats did not. In rats that went untreated for 3.5 months and then received AG1478, cell death was halted. The authors suggest that EGFR activation of astrocytes may play a detrimental role after injury. Bin Liu, Huiyi ...Friend or foe: Could a protein linked to Alzheimer's be related to vision loss in seniors?
...ickens, or does essentially nothing to the rate of retinal degeneration in genetically altered mice that undergo progressive, age-dependent vision loss. Fliesler's team will selectively introduce either the human apoE-3 or apoE-4 gene into the mice and then study what effects this may have on the structure a...$1.4 million grant helps professor see the light
... exquisitely light-sensitive enzyme can also cause retinal disease when its regulation or catalytic activity ...apeutically to prevent defects in PDE from causing retinal disease." Working with graduate and undergraduate students in his lab, along with three full-time...News tips from the Journal of Neuroscience
... Thompson et al. show that Slits help restrict the retinal ganglion cell (RGC) axons to the optic fiber layer (OFL) in the ventral retina, but in dorsal retina they affect the orderly growth of axons within the OFL. RGCs expressed slit1 and slit2 , both of which are chemorepellant for RGC axons. In wild-t...News tips from the Journal of Neuroscience
...authors examined the network of ON and OFF parasol retinal ganglion cells (RGCs) in the macaque monkey retina. Their 512-electrode recordings allowed them to sample most, if not all, of the parasol RGCs in a 35 mm circle of peripheral retina. To reduce the number of possible input patterns for n cells from...Walgreens and Joslin Diabetes Center form broad alliance to improve diabetes outcomes
...he JVN is the most thoroughly validated diagnostic retinal imaging service offering patients a pain-free and non-dilated diabetic eye evaluation that facilitates further examination by eye care specialists to treat diabetic retinopathy and other pathologies. The JVN is already in use at more than 50 clinica...Gene therapy for inherited childhood blindness tested in mice
...aused by mutations in a gene active in the retina, retinal pigment epithelium-specific protein, 65 kDa (RPE65...s in these mice showed that the treatment restored retinal function to near-normal levels and prevented degeneration in one type of retinal cell-the cones-unti...Vax and Pax: Taking turns to build an eye
... optic nerve cord, and Pax6, a protein that drives retinal fate--playing on the same field. That puzzle is ex... that Vax2 protein is indeed expressed in the same retinal cells as Pax6, but that Vax2 shuttles in and out of the nucleus in response to a signaling molecule ...... ants searched for the food at 20cm away where the retinal size of the landmark was the same." To analyse the ants' powers of recall an ambiguous situation was set up. Ants were trained to search for food between two cylinders of different sizes and then tested with the training cylinders replaced by two cy...Funnel in the eye: Signal focusing increases photosensitivity
... They switch from the comparatively less sensitive retinal cones to the far more sensitive rods. Since the latter only record differences in brightness and no colours,in the dark all cats are grey, as the saying goes. Grey and blurred: in faint light the amacrine II cells additionally focus the signals fr...