Tag: "retinitis" at biology news

Retinal stem cells can regenerate after transplant

...ure treatment of degenerative eye diseases such as retinitis pigmentosa and macular degeneration but that's still a long way off, says Coles. She, van der Kooy and their colleagues are now exploring whether retinal stem cells from healthy mice continue to develop into photoreceptor cells and RPE cells when tra...

'Blind' cells see the light; maybe someday humans will, too

...r eyes because of nerve damage or diseases such as retinitis pigmentosa or age-related macular degeneration. In these cases, the photoreceptor cells are dead, but other nerve cells downstream of the photoreceptors are still alive. In particular, retinal ganglion cells, which are the third cell in the path from...

Researchers discover way to make cells in the eye sensitive to light

...pies for treating some forms of blindness, such as retinitis pigmentosa. Retinitis pigmentosa is a form of hereditary blindness where the rods and cones are destroyed, but the rest of the eye and retina remains intact. By switching on the melanopsin it could be possible to restore the eyes ability to respond t...

Secrets of the cilia: Kidney disease and blindness share common genetic defect

...nophthisis*, as well as a form of blindness called retinitis pigmentosa. In both the eye and the kidney, U-M s...ia in the light-sensitive portion of the eye cause retinitis pigmentosa." For the past 15 years, Hildebrandt and his collaborators have been studying nephronopht...

Ophthalmologists and physicists team up to design 'bionic eye'

... vision. Worldwide, 1.5 million people suffer from retinitis pigmentosa (RP), the leading cause of inherited blindness. In the Western world, age-related macular degeneration (AMD) is the major cause of vision loss in people over age 65, and the issue is becoming more critical as the population ages. Each year...

Ophthalmologists implant five patients with artificial silicon retina microchip

...es of five patients to treat vision loss caused by retinitis pigmentosa (RP). The implant is a silicon microchi... retinal diseases such as macular degeneration and retinitis pigmentosa, which cause blindness and vision impairment in about 10 million Americans. More than one...

Six previously blind patients detect light, motion, identify objects with retinal prostheses

...ght perception due to the degenerative eye disease retinitis pigmentosa (RP). Ultimately, however, the device is likely to be used for the millions of people suffering from age-related macular degeneration, or AMD, as well. In fact, notes Humayun, there are 25 million people across the globe, including 6 milli...

Gene therapy works in mice to prevent blindness that strikes boys

...olve the eye's ability to process light, including retinitis pigmentosa, which affects about 200,000 people in the United States and is one of the most common inherited causes of blindness in people between the ages of 20 and 60. "We've been very successful in curing a disease in mice that has a direct copy in...

Genetic testing helps physicians zero in on eye disease

...es for patients with the blinding disease known as retinitis pigmentosa (RP). The screening technique has proven to be reliable and cost-effective. In the September issue of Investigative Ophthalmology & Visual Science (IOVS), scientists at the U-M Department of Ophthalmology and Visual Sciences report on the ...

Scientists link another gene to degenerative blindness

...such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP). It has been a painstaking scientific journey as AMD and RP each belong to a complex family of disorders, in which every disorder has many forms and each form is encoded with a distinct genetic recipe. Even AMD, a major cause of visio...

A new way of looking at molecular motors

...a variety of human and animal disorders, including retinitis pigmentosa (which causes blindness), polycystic kidney disease, brain development defects, neurodegenerative diseases, muscular dystrophy, skin pigmentation problems, and genetic hearing loss. Researchers led by Dominique Soldati, a Howard Hughes Me...

'Prosthetic' retinal cells let blind mice see light

...es the defect in such inherited human disorders as retinitis pigmentosa. Unlike the retinal rods and cones that normally function as light-sensing cells in the eye, these retinal neurons are normally not photosensitive. The light-sensitive protein they used, called channelrhodopsin-2 (ChR2), is found in green ...

Fish oil may help protect against retinal degenerative diseases

...ells in the retina from degenerative diseases like retinitis pigmentosa and age-related macular degeneration, t... DHA, known to be in short supply in patients with retinitis pigmentosa and Usher's syndrome, promotes protective cell signaling by facilitating the expression o...

Blind mice recover visual responses using protein from green algae

... This condition is similar to the blinding disease retinitis pigmentosa (RP) in humans. Vision normally begins when rods and cones, also called photoreceptors, respond to light and send signals through the retina and the optic nerve to the visual cortex of the brain, where visual images are formed. Unfortunate...

Study provides first look at the 'birth' of a retina cell

...root of eye diseases such as diabetic retinopathy, retinitis pigmentosa, and macular degeneration. In most instances, including age-related macular degeneration, rod photoreceptors die before cones. As the mouse eye develops, rods start out as stem cells, meaning they have not yet been assigned a function and ...

$1.4 million grant helps professor see the light

... of vision and that, when defective, can result in retinitis pigmentosa, a leading inherited cause of blindness. Retinitis pigmentosa, or RP, affects 1.5 million people worldwide. Typically, symptoms begin in childhood or early adulthood and progress from impairments in night vision to tunnel vision. The deg...

Transplanted photoreceptor precursor cells restore visual function in mice with retinal degeneration

...ases, such as age-related macular degeneration and retinitis pigmentosa, it is the loss of photoreceptors that leads to blindness. Understanding the birth of photoreceptorsIn 2001, Swaroop's team first showed that the gene NRL, discovered several years earlier in his U-M lab, is essential for the developme...

The National Academies' Distinguished Speaker Series runs Jan. 17-March 21, 2007

...discoveries about the effects of eye diseases like retinitis pigmentosa and age-related macular degeneration, and his work is restoring hope to those who previously had little chance of seeing again. Mark Humayun, M.D., Ph.D., is professor of ophthalmology and biomedical engineering, University of Southern Ca...

Unfolded proteins may protect cells from dying

...titute investigator, focused on autosomal dominant retinitis pigmentosa (ADRP), which causes blindness. Unfolded proteins linked to ADRP accumulate in the endoplasmic reticulum, an organelle where proteins are manufactured and packaged for transport to the cell surface, unlike some other forms of the unfolded ...

U-M team: Genetic testing sheds light on degenerative eye disease

...130 genes associated with retinal disease, such as retinitis pigmentosa and macular degeneration. The authors observe that genetic testing for eye disease is a relatively new and evolving practice. Says Ayyagari, Molecular diagnostics does not replace the necessary expertise of the ophthalmologist; rather, ...

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(Date:10/18/2014)... a sample of patients with undiagnosed, suspected genetic conditions, ... with a higher molecular diagnostic yield than traditional molecular ... JAMA . The study is being released to coincide ... , Exome sequencing, which sequences the protein­coding region of ... material present in a cell or organism), has been ...
(Date:10/16/2014)... wages war on the human body. Battles are ... In pancreatic cancer, this stalemate—known as tumor dormancy—can ... malignant, a phenomena that is poorly understood. ... laboratory of Salvatore Torquato, a Professor of Chemistry ... surrounding tumor dormancy and the switch to a ...
(Date:10/16/2014)... respiratory tract infections and worldwide claims the lives ... and Ghent University have succeeded in developing a ... infection. , Xavier Saelens (VIB/UGent): "We discovered ... for the development of a novel approach to ... in numerous small children and elderly people." , ...
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