Tag: "retroviral" at biology news

Scottish scientists win 800,000 to boost research into fighting killer viruses

...ses evolve and will help explain late steps in the retroviral life cycle. Understanding how enJS56A1 functions could provide a model for designing new anti-retroviral therapies that work on cells already infected by retroviruses. Many current anti-retroviral drugs function only immediately after the virus infec...

Study reveals candidate targets for anti-retroviral therapeutics

...st elements) encode proteins that are homologs of retroviral proteins. The proteins encoded by Ty elements and the steps of the life cycle in yeast are similar to the proteins encoded by retroviruses and their life cycles in animal cells. Scientists believe that these simple elements in a single-celled organ...

Gene therapy completely corrects hemophilia in laboratory animals

... needed and used a large viral vector called gamma retroviral vector. The viral vector carrying factor VIII genes was injected into the blood of 11 newborn hemophilic mice and two newborn hemophilic dogs. The viral vector also contained a short DNA promoter sequence to make the gene active only in liver cells...

Retroviral resistance gene found

...tephen Goff and colleagues have identified a novel retroviral resistance gene, called FEZ1, that can mediate a p...ratory rat cell line caused a significant block to retroviral infection retroviruses were able to enter the host cells and synthesize the viral DNA, but were exc...

Stephen P Goff awarded inaugural Retrovirology Prize

...irst investigators to clone a functional copy of a retroviral genome, and to use recombinant DNA methods to study viral replication. Over the last two decades Dr. Goff has developed and exploited the Moloney murine leukemia virus as a genetic system. One of his most important results was the definition of the ...

JCI table of contents September 1, 2005

...on of blood monocyte activation and infection with retroviral therapy rapidly reduces CNS neuronal injury. Animals on retroviral therapy show no accumulation of macrophages in the CNS or detectable virus, in contrast to non-treat...

Crisis in African fish supplies looms, experts warn Africa leaders

...y infections while increasing the effectiveness of retroviral drugs. "Small fish ponds are a valuable addition to farms without substantially adding to the labour burden," says Daniel Jamu, the WorldFish Center's program director for southern Africa, adding that HIV and AIDS affected families in Malawi, includi...

A clue from macaques yields evidence for impaired retroviral defense genes in humans

...n were responsible for this difference in battling retroviral infection. This prompted the Malik and Emerman gro... history corresponding to relatively low levels of retroviral infections may have allowed impaired versions of retroviral defense genes--such as the hobbled versi...

New human retrovirus originated in mice

...st really solid example of an authentic xenotropic retroviral infection in a human being," said Ganem. According...RNASEL is an important part of the defense against retroviral infection. This is the first evidence in humans of findings that were previously made only in vitro....

'Resonance' may explain virologic failure in STI drug therapy

...chers suggest. Resonance is observed when the anti retroviral drugs cannot reduce the viral load. "Resonance is a very general phenomenon that has been long known in physics and engineering," Breban said. "We are the first to apply it to virology." "At the beginning of treatment, the patient's viral load is qui...

Scientists discover new regulating mechanism in cells

...ause it has something important in common with the retroviral proteins. The mRNA in both cases does not pass through the processing step of the four-step protein-making process. Normally, that processing step also adds a signal to the mRNA that facilitates the final making of the protein. Because mRNAs like th...

Researchers discover that sheep need retroviruses for reproduction

...retroviruses can be considered remnants of ancient retroviral infections, Spencer said. Many scientists believed these endogenous retroviruses were junk DNA, he said. "Indeed, these endogenous retroviruses are usually harmless and generally contain mutations that prevent them from producing infectious retrov...

Phoenix rising: Scientists resuscitate a 5 million-year-old retrovirus

...(HML2) family, an evolutionarily "young" family of retroviral elements. They aligned HERV-K(HML2) elements, det...' that may be responsible for the synthesis of the retroviral particles that can be observed in some human cancers such as germline tumors and melanomas," says He...

UCLA AIDS Institute researchers find a peptide that encourages HIV infection

...ty of HIV-1 to enter a broad range of human cells, retroviral vectors are currently being explored as vehicles f...rote. "In this area, at least, agents that enhance retroviral uptake could contribute to an emerging field of medicine." "So many people have tried to deliver ...

Ancient retrovirus sheds light on modern pandemic

...r many millions of years, and so humans share many retroviral DNA fragments with their primate cousins. Such vestiges of primitive infection, rendered inactive by eons of genetic mutation, make up about 8 percent of the human genome. Innate protection against PtERV1 in humans could be credited, the researchers ...

JCI table of contents: August 1, 2007

...to divide uncontrollably. Analysis of the sites of retroviral integration in individuals treated with gene thera...population. Although the diversity of the detected retroviral integration sites decreased following transplantation into patients because the treated cells differ...

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(Date:10/14/2014)... Research shows SIRT6—a protein known to inhibit the ... of skin cancers by turning on an enzyme that ... , Previously considered protective, SIRT6 is part of a ... genomic stability and prevent some of the genetic flaws ... can lead to cancer. This study, in the journal,s ...
(Date:10/14/2014)... N.Y. – Scientists have sequenced the house fly genome ... one might expect from an insect that thrives in ... published Oct. 14 in the journal Genome Biology ... biology and of how flies quickly adapt to resist ... Adult house flies (Musca domestica) carry and transmit more ...
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