New gene therapy promising for treating Fabry disease
...ed that an engineered lentiviral vector a type of retrovirus administered a day or two after birth can correct the defect long term in Fabry mice, ensuring they produce the appropriate enzyme at relevant levels. Further testing will be required before the therapy can be tried in humans. "Our previous strate...Scottish scientists win 800,000 to boost research into fighting killer viruses
... enJS56A1 interferes with a pathogenic 'exogenous' retrovirus (JSRV), the cause of major infectious diseases of sheep. enJS56A1 forms viral particles that 'stick' together and cannot exit the cell and spread to other cells. JSRV instead forms particles normally able to exit the cell. However, when JSRV and enJS......ssemblies scattered all over their surfaces. These retrovirus surface proteins cause the membrane envelope of th...o how the virus locks onto the cell membrane. The retrovirus used by Fass and the team is similar to that which causes leukemia in humans. They hope, with furthe...Study reveals candidate targets for anti-retroviral therapeutics
... genome, thus providing a rich source of candidate retrovirus host genes. Sandmeyer and colleagues hope that this study, along with related studies of retrovirus-like elements in yeast, will ultimately lead to the development of a new generation of anti-retroviral therapeutics....Two new retrovirusestransmitted from animalsidentified
..., which described the discovery of another primate retrovirus in hunters, the simian foamy virus (SFV) in the Ma...iven the incredible potential costs of a new human retrovirus into the general population, the development of sentinel systems for forecasting disease emergence--...Science study holds implications for gene therapy and stem cell biology
...d team revealed that the insertion of several such retrovirus vectors into a single blood-forming stem cell can ...nd activated by the random insertion of a disabled retrovirus appear to have exactly this property: They can increase the multiplication rate of stem cells. While...Results of world's first gene therapy trial for arthritis show approach safe, feasible
... evidence that the vector, a replication-defective retrovirus called Maloney Murine Leukemia Virus, has since become capable of replication in their patients. "At the outset, our primary objective was proving the safety of gene therapy, especially for a clinical application to a nonlethal disease, such as arthr...Stephen P Goff awarded inaugural Retrovirology Prize
...sh award in recognition of his excellence in basic retrovirus research. Editor-in-Chief Kuan-Teh Jeang writes about the award in an editorial published this week in the Open Access journal Retrovirology. The editorial includes an interview with Goff, about his career, inspirations and achievements. The Retrovi...Primate virus jumps species barrier to humans for first time in Asia
...-human transmission of simian foamy virus (SFV), a retrovirus found in macaques and other primates that so far has not been shown to cause disease in humans. The transmission of the virus from a monkey to a human took place at a monkey temple in Bali, Indonesia, the researchers report in the July issue of the j...Duke professor to lead $300 million NIH center for HIV vaccine research
...cognized leader in basic T- and B-cell immunology, retrovirus research and HIV vaccine development. "Making a vaccine for AIDS has turned out to be more difficult than we ever anticipated," Haynes said. "With this award, our CHAVI team will work with the HIV research community in a new model that places great ...Performing monkeys in Asia carry viruses that could jump species to humans
...d positive for simian foamy virus (SFV), a primate retrovirus that so far has not been shown to cause disease in...sia. Two of the monkeys tested positive for simian retrovirus (SRV), which, though it has been shown to infect humans in a laboratory setting, has yet to be assoc...'Virus chip' detects new virus in prostate tumors
... from another species, it is known as a xenotropic retrovirus in this case, a xenotropic murine-like retrovirus, or XMRV. This is not the first virus of this family to be discovered, but it appears to be the first one found in humans, the scientists report. The new virus is 96 percent identical to a class of ...New human retrovirus originated in mice
...archers and their colleagues have discovered a new retrovirus in humans that is closely related to a cancer-caus...e first documented cases of human infection with a retrovirus that is native to rodents. The researchers discovered the virus in patients with a rare type of pros...Paper reports discovery of virus implicated in genetics of prostate cancer
...n article detailing research that identifies a new retrovirus in the tissue of human prostate tumors. The research was first announced at an American Society of Clinical Oncology Meeting, but only now is the full, peer-reviewed report available. The paper, entitled "Identification of a Novel Gammaretrovirus i...Scientists discover new regulating mechanism in cells
...n RHA is knocked out, the spleen necrosis virus, a retrovirus Boris-Lawrie and her collaborators were studying a...s knocked out the RHA protein and learned that the retrovirus stopped making several vital proteins. "That suggests that the retrovirus needs RHA to make these e...Protein from the wrong side of the tracks aids cancer virus
...the human T cell leukemia virus type 1 (HTLV-1), a retrovirus and a distant cousin to HIV, the cause of AIDS. The findings indicate that HBZ enhanced the ability of HTLV-1 to establish a persistent infection in an animal host. The study by researchers with the Ohio State University Comprehensive Center and the...News tips from the Journal of Neuroscience
...thors injected adult rat brain white matter with a retrovirus driving expression of green fluorescent protein (G...ngers in tumor growth. Progenitors infected with a retrovirus expressing GFP alone did not cause tumors, rather these cells differentiated into oligodendrocytes. ...Joe Sodroski wins the 2006 Retrovirology Prize
...inner was Stephen P Goff at Columbia for his basic retrovirus research. The M Jeang Retrovirology Prize winner is selected, by Retrovirology's editors, from nominations submitted via the journal's Editorial Board. Representing the Editors of Retrovirology, Prof. Andrew Lever of Cambridge University, the UK, ...Viruses can jump between primates and humans, researchers warn
...y virus (SFV) from a monkey bite. SFV is a primate retrovirus that so far has not been shown to cause disease in humans. Monkey temples are religious sites that have become gathering spots for populations of wild macaque monkeys fleeing deforested areas. "This study is basically the first step in quantifying t...Researchers discover that sheep need retroviruses for reproduction
...ndogenous retroviruses related to Jaagsiekte sheep retrovirus or enJSRVs, are critical during the early phase of...ls have shown that a protein of a human endogenous retrovirus might have a role in development of the human placenta. The team blocked expression of the envelop...