NIH awards new $14.5 million, five-year grant to the Scripps Research Institute
... of all the proteins in the human body, which will reveal a wealth of information on the biology of human health and disease. "Everybody feels that structural biology needs better tools for producing certain types of proteins, particularly for membrane proteins," says Scripps Research Professor Raymond St......rent Human Species Evolved Together Our genes reveal the evolutionary history only of modern humans. Fossil evidence is scant for now-extinct species of early humans. Because lice evolved in concert with the humans they infested, lice "have recorded events in human evolutionary history in their DNA," R...Researchers provide road map for generating B cells from stem cells
...ome, and blocking off other options. "Our findings reveal considerable complexity, but are promising from the standpoint of directing stem cell differentiation," said Harinder Singh, Ph.D., Louis Block Professor of Molecular Genetics and Cell Biology and an Investigator with the Howard Hughes Medical Instit...Mitochondria findings may help beat wide range of disease
...ynamic mitochondrial behavior has the potential to reveal keen insights into the basic and essential cell-mitochondria relationship, leading to increased understanding of the aging process; and potential treatments and perhaps cures of those age-related scourges of Parkinson's and Alzheimer's."...Study in Royal Society journals presents evidence for inherited factors in homosexuality
... natural selection in dragon lizards. Our results reveal that in species occupying closed habitats, both sexes are ornamented and males are more conspicuously coloured than females. In contrast, species occupying open habitats tend to be less ornamented and males tend to be conspicuously coloured only on ...Coke versus Pepsi: It's all in the head
...und. Brain scans of people tasting the soft drinks reveal that knowing which drink they're tasting affects their preference and activates memory-related brain regions that recall cultural influences. Thus, say the researchers, they have shown neurologically how a culturally based brand image influences a be......ntrol brains. "These studies not only reveal important changes in the neurotransmitter systems of autistic brains, but also the specific regions of the brain in which they occur," says Blatt. "Together, this information may ultimately help guide pharmaceutical companies to develop drugs that sp...Clues to the puzzle of 'talking' root cells
...any molecular complex. However, the tracer did not reveal that the protein was moving from one cell to anoth... Thus, he said, the researchers hope ultimately to reveal the machinery by which the developing cells talk to one another in the critical process of generatin...Mystery unwrapped: Texas A&M team uncovers mummy secrets
...gyptians used contains molecular fingerprints that reveal interesting information," Kennicutt explains. "First, we are able to 'fingerprint' the tars from mummies that were embalmed as early as 900 B.C. These fingerprints can then be matched with known oil seeps to establish their origin. "Al...Powerful 'toolkit' developed for functional profiling of yeast genes
...icroorganism. Eventually the work with yeast could reveal particular gene interactions that could become targets for therapies to fight cancers or fungal infections, say the researchers. The toolkit, a combination of techniques developed by the Hopkins researchers and others, starts with a collection of alm...Conversion of flower organs into leaves
...rful, such an approach nevertheless often fails to reveal the essential nature of closely related genes that are functionally redundant. Functional redundancy refers to the situation where two or more genes play very similar roles and must be simultaneously inactivated if the abnormal characteristic is to b...Acetaminophen shows positive in vivo cardioprotective effects in heart attack, arrhythmia
... our recent work in vitro to the in vivo arena and reveal salutary effects of acetaminophen in the neurohumo... to dogs and not to humans. More work is needed to reveal the potential salutary effects of this agent in other tissues and organ systems under other physiolo...Genetic influences on taste perception of alcohol may influence alcohol intake
...OP), and perceived intensity of alcohol. Findings reveal that both bitter taste perception and genotype make overlapping and independent contributions to oral sensations from alcohol and alcohol intake. "We do not all share the same oral sensory experiences from foods and beverages," said Valerie B. Duffy...New tool highlights activity of key cellular signal
...ent phenomenon to study the molecular changes that reveal cells' inner workings. Much like a child might pass along a visitor's request to a grown-up, cyclic AMP carries messages from hormones or other molecules "knocking" at the cell's door to proteins inside the cell. But because cyclic AMP uses just a...JCI table of contents, November 15 2004
...tion, German researcher Jorge Frank and colleagues reveal the molecular basis of type 2 mosaicism in Hailey-Hailey disease. The authors isolated skin cells from severely affected areas of a female patient and found that skin cells from patterned skins lesions possessed a defect in the gene ATP2C1, which enc...Researchers piece together the puzzle of Hailey-Hailey skin disease
...tion, German researcher Jorge Frank and colleagues reveal the molecular basis of type 2 mosaicism in Hailey-Hailey disease. The authors isolated skin cells from severely affected areas of a female patient and found that skin cells from patterned skins lesions possessed a defect in the gene ATP2C1, which enc...Heart responds to fasting by remodeling vital energy-producing components
...of extreme starvation. The researchers' data also reveal that after feeding resumes, the phospholipid levels in heart muscle cells rise back to normal levels, indicating that mitochondria readily rebuild their membranes. During this recovery period, another class of lipid, triglyceride, a common source of...Acid-resistant bug doesn't give in to alcohol either
... That answer, Kappock said, could reveal many new important insights.Kappock discussed his research at the American Chemical Society's Annual Meeting, held Aug. 23-25, 2004, in Philadelphia.Specifically, Kappock and his research group study the enzyme citrate synthase, one of the oldest enz......est study by Heberlein, Blau, and their colleagues reveal a more complex neurological process. From 400 different mutants, they identified seven with an increased response to cocaine, and for two of these, the disrupted gene was the same--Lmo. The Lmo protein, whose levels were reduced by the mutatio......egment of DNA. They then used x-ray diffraction to reveal the structure of the complex. Unexpectedly, they found that unlike the yeast version of the protein, human POT1 contained two distinct OB-folds. The grooves of the two folds align with one another, forming a continuous channel where the telomeric DNA...