Unravelling new complexity in the genome
...dy published in the latest issue of Genome Biology reveals that a step in gene expression (referred to as alternative splicing) is more highly regulated in a cell and tissue-specific manner than previously appreciated and much of this additional regulation occurs in the nervous system. The alternative splic...Features of replication suggest viruses have common themes, vulnerabilities
...tributes. Such a discovery is important because it reveals a common viral theme that may be vulnerable to disruption and could lead to the development of drugs to treat many different kinds of viral infections, much like antibiotics are used to attack different kinds of bacterial pathogens. "It turns out t...MIT creates 3-D images of living cell
...onds. The team's image of a cervical cancer cell reveals the cell nucleus, the nucleolus and a number of smaller organelles in the cytoplasm. The researchers are currently in the process of better characterizing these organelles by combining the technique with fluorescence microscopy and other techniques. ...High blood pressure, low energy -- a recipe for heart failure
...ld explain that difference. Their latest research reveals that impaired energy production in heart muscle may underlie heart failure in some hypertensive patients. The researchers assert that a molecular factor involved in maintaining the heart's energy supply could become a key to new approaches to prevent...Antioxidant overload may underlie a heritable human disease
...w study in the August 10 issue of the journal Cell reveals that, in fact, balance is the key. The researchers show in mice that an overload of natural antioxidants can actually lead the heart to failure. There is plenty of evidence about the damaging effects of oxidative stress, but there is another side t...A study by the MUHC and McGill University opens a new door to understanding cancer
...chanisms to be minutely controlled. This new study reveals that ubiquitin also promotes interactions between proteins known as Cb-b. In a healthy patient, Cb-b is activated when a growth factor attaches itself to the surface of a cell, its role being to mitigate the cell proliferation and growth mechanisms i...Satellite tracking reveals threats to Borneo pygmy elephants
...ities and forest disturbance. Data gathered so far reveals there are probably not more than 1,000 pygmy elephants left in Sabah less than the 1,600 or so estimated previously. And, one important area for the elephants, the Lower Kinabatangan Wildlife Sanctuary, may be too small and too fragmented to suppo...Surprising new species of light-harvesting bacterium discovered in Yellowstone
...a very large scale. Analysis of the DNA sequences reveals what types of genes and organisms are present in the environment. The team focused on two genes: 16S ribosomal RNA, a crucial component of the machinery used by all living cells to manufacture proteins; and the gene for a protein called PscA, which ...Innovative research technique reveals another natural wonder in Yellowstone Park
... a very large scale. Analysis of the DNA sequences reveals what types of genes and organisms are present in t... an excellent example of how metagenic information reveals how little we know about life on Earth," said Weiner. Members of the phylum Acidobacteria have pro...More fish oil, less vegetable oil, better for your health
...rt all the vegetable oil available. This finding reveals for the first time a limit to how the body naturally regulates levels of prostanoids produced by fish and vegetable oil. If both oil types are present in the body, levels of prostanoids from fish oil will, in general, be higher than those coming from...UCLA study links air pollution to clogged arteries
.... The interaction left a genetic footprint that reveals how interaction between the particles and cholesterol accelerates the narrowing and blockage of the blood vessels, Araujo noted. To duplicate these findings in living cells, the UCLA team exposed mice with high cholesterol to the diesel particles a...Radiation therapy combined with microsurgery shows promise for curing injured spinal cord
...ith crushed spinal cords, similar to human injury, reveals that treatment soon after injury combining radiation therapy to destroy harmful cells and microsurgery to drain excess fluids significantly increases the bodys ability to repair the injured cord leading to permanent recovery from injury, according to...Enzyme discovery sheds light on vitamin D
...Biochemistry student Brendan OLeary, the discovery reveals that changing a single amino acid in the hydroxylase enzyme will cause it to take a completely different pathway. Although scientists have known for 25 years that the enzyme is capable of taking two different pathways, until now they could not explai....... By examining PPAR functions in vivo, our work reveals an unexpected link between diet, inflammation and the quality of mothers milk, explained Dr. Evans. PPAR (peroxisome proliferator-activator receptor gamma) is a nuclear receptor that is known to regulate metabolism and inflammation in various orga...Charting ever-changing genomes
...Proceedings of the National Academy of Science. It reveals the regions that are currently targeted by natural selection or have been so during the evolutionary past. In an independent study the collaborators -- this time led by Detlef Weigel, Ph.D., director of the Max Planck Institute for Developmental Bi...What determines the speed at which birds fly?
...hird of all European bird species). Their analysis reveals that the difference between the speed of small and large birds is not as great as expected; they suggest that this surprising result is likely to be the result of disadvantages associated with very slow speeds among smaller birds and with very fast s...Clues to future evolution of HIV come from African green monkeys
... lineage split into four species. The new research reveals the split happened about 3 million years ago. Previously, scientists thought SIV infected an ancestor of green monkeys before the lineage split, much longer ago. "Studying SIV helps us learn more about HIV," said the paper's first author Joel W...New use for a cell toxin found to inhibit survival proteins in cancer cells
... paper. Funding for the study, 2-Methoxy antimycin reveals a unique mechanism for Bcl-xL inhibition, came from the New Technology Development Fund administered by the Hutchinson Center. Additional key investigators in Hockenberys lab included Michael Manion, Ph.D., and Pam Schwartz, Ph.D., and John Fry. ...Pumpkin: A fairytale end to insulin injections?
...iabetics currently have to endure. Recent research reveals that pumpkin extract promotes regeneration of damaged pancreatic cells in diabetic rats, boosting levels of insulin-producing beta cells and insulin in the blood, reports Lisa Richards in Chemistry & Industry, the magazine of the SCI. A group, le...... symptoms. It is the first time that a mouse model reveals increased cell death as the mechanism underpinning kidney degeneration in NPHP. The genetic cause is a mutation in a gene called GLIS2. GLIS2 normally prevents cell death in the adult kidney. It does so by shutting down genes that initiate cell dea...