US clinical researchers resist full financial disclosure, according to Conflicts-of-Interest Study
..., conflict-of-interest committees and researchers, reveals a key reason for the reluctance among researchers to share the full dollar amount: the belief that because potential research subjects may lack the sophistication to put conflicts of interest in context, they may overestimate the influence of money ...Genetic surprise confirms neglected 70-year-old evolutionary hypothesis
...The finding, reported in today's issue of Science, reveals that scientists must reassess the process involved in the origin of species. The beginnings of speciation, suggests the paper, can be triggered by genes that change their locations in a genome. "In the 1930s there was speculation that parts of chromo...Fast-freeze snapshot yields new picture of nerve-muscle junction
...ng a flash-freeze physical-fixation technique that reveals new details of their location and function in neuromuscular synapses. The technique was used with tiny, one-millimeter-long nematode worms, a lab animal widely studied by neuroscientists. Investigators report the finding in the Aug. 2 issue of the J...Untangling a pathology of Alzheimer's
...The researchers concluded that their work not only reveals a significant protective factor in fibrillary tangle disorders, but points the way for further searches of other such factors. They wrote that "This work provides a clear proof of principle for validation of genetic screens using model systems and al......n the seafood trade between Europe and West Africa reveals that, in general, trade does not decrease food security," said Dr Allison. "This is because the fish that are traded internationally are generally higher-value species, such as tuna, hake, sole, shellfish, octopus and squid, which would have been d......st important model organisms. More importantly, it reveals that MEL-28 is one of the key architects as bits of membrane and proteins are drawn together to build new envelopes. When scientists blocked the activity of MEL-28, they discovered that patches of membranes attached themselves to DNA but couldn't se...Impact of forest certification in developing countries examined
...parative, historical analysis, spanning 622 pages, reveals that existing interest and commitments from North American and European markets have not been strong enough to influence forest management choices significantly in some of the world's most environmentally sensitive forests. The editors argue that ...Mature muscle fibers can revert to become cancerous, researchers find
... genetic causes of rhabdomyosarcoma." "Second, it reveals a fascinating biological process in which a human gene for rhabdomyosarcoma causes skeletal muscle fibers to undergo a reverse form of development and generate single cells that spread through the organism," said Dr. Olson, director of the Nancy B. a...DOE JGI, VBI describe disease mechanisms of sudden oak death, related soybean pathogens
...e weakened by P. ramorum. In leaves, the pathogen reveals its presence through blight and twig dieback. In this manifestation, the disease can be transmitted by such plants as California bay laurel, camellia, and rhododendron. The economic impact of Phytophthora sojae is far-reaching. The U.S. produces a...Study provides first-ever look at combined causes of North Atlantic and Arctic Ocean freshening
...f hydrologic trends in the Arctic. Their analysis reveals that freshwater increases from Arctic Ocean sources appear to be highly linked to a fresher North Atlantic. "The high-latitude freshwater cycle is one of the most sensitive barometers of the impact of changes in climate and broad-scale atmospheric...Mouse mimics chronic leukemia, will aid drug development
...UMBUS , Ohio -- A study by cancer researchers here reveals that a new strain of mice offers the first real animal model for an incurable form of chronic leukemia and should greatly aid the development of new drugs for the disease. The mouse, called the TCL-1 transgenic mouse, develops a malignancy that cl...Major genetic risk factor found for prostate cancer
...dentified. Scientific Summary: Admixture mapping reveals locus for prostate cancer risk Admixture mapping entails scanning the genes of mixed ancestry populations to find regions where the proportion of DNA inherited from either ancestral side is unusual compared to the genome-wide average. This techniqu...Study provides insight into how the brain loses plasticity of youth
...n. "Our study of mutant mice lacking PirB function reveals that at all ages, even during critical periods when circuits are prone to change, there are active molecular mechanisms that function to limit synaptic plasticity," said Josh Syken, HMS instructor in neurobiology and lead author of the study. One...Brain's cannabinoid system 'mellows' seizures
...icano, and colleagues. "In conclusion, our study reveals a mechanism through which the endocannabinoid system is able to provide on-demand protection against acute behavioral seizures. CB1 expression on hippocampal glutamatergic circuits accounts for this protection and might represent a suitable target fo...Genetic snooze button governs timing of spring flowers
...iate flowering in the spring. What they have found reveals some of the complex interplay of genes and environment and provides hints that, one day, it may be possible to exert precise control over flowering, a process essential for plant reproduction and fruiting and that has enormous implications for agricu...Study illuminates birth defects caused by copper deficiency
A new study reveals the timing of developmental events that critically depend on copper. While copper deficiency is rare in humans, the findings suggest that suboptimal copper metabolism might contribute to birth defects, according to the researchers. The discovery in...Ossur takes another giant step in prosthetic technology
...echnologies yet to come for lower limb prosthetics reveals osseointegration, the science of implanting man-made, load bearing anchoring mechanisms directly into the living bone. The fixture bonds with the surrounding tissue and ultimately the prosthesis is attached to it and can withstand all normal conditio...Ocean microbe census discovers diverse world of rare bacteria
...of magnitude greater than previously available and reveals the enormous range of genetic diversity of different microbes in the ocean," she says. Says co-author Gerhard Herndl of the Netherlands: "Once we catalog the diversity of microbial life in the sea, we can look for patterns and trends in the distr...Research simplifies diagnosis of Charcot-Marie-Tooth disease
...irection of Vincent Timmerman and Peter De Jonghe, reveals how important MFN2 is in the origin of CMT2. They studied 323 CMT patients, 249 of whom suffer from CMT2. From the study of these patients (and 170 healthy individuals), it is clear that mutations in MFN2 are the major cause of CMT2. On the basis of ...