New grants bolster efforts to generate faster and cheaper tools for DNA sequencing
...imization of a novel set of fluorescent nucleotide reversible terminators for sequencing by synthesis. A new method for preparing DNA-beads for attachment to a substrate will also be developed. The goal is to increase the length of the DNA sequencing reads while maintaining high data quality. David C. Schwa...Boston Univeristy bioengineers devise 'dimmer swith' to regulate gene expression in mammal cells
...s function off, said Deans. This switch is also reversible and tunable. By adding a chemical -- Isopropyl--thiogalactopyranoside -- the repressor components are blocked and the gene turns on again. The genes activity can be tuned up or down by adjusting the amount of this chemical. The researchers demonst...Synthetic adhesive mimics sticking powers of gecko and mussel
...nctions like a sticky note and exhibits strong yet reversible adhesion in both air and water. The findings, w...Nature. The geckel material should be useful for reversible attachment to a variety of surfaces in any environment, said Phillip B. Messersmith, professor of bi...Nature's secrets yield new adhesive material
...ategies in nature have been merged into a man-made reversible adhesive. Our work represents a proof of principl...thetic compound. This unusual compound mimics the reversible bonding action of a mussel adhesive protein that Messersmiths group has studied for the past several...Implanon, Norplant and Jadelle are all effective contraceptives -- but side effects vary
...ermal implantable contraceptives compared to other reversible methods of contraception found that they were all good at preventing pregnancy. No one subdermal implant was found to be any more or less effective than the others in preventing unwanted pregnancies. The most common side effect with all the implant......researcher affirms, because alcohol is a drug with reversible effects up to a point. In relation to the botelln culture (gathering in the streets to drink with friends), Jos Rico states that some of these social drinkers could have low beta-endorphin levels and, therefore, a higher predisposition to become ...Turn-ons and turn-offs for neurons
...ystems and delineated the necessary conditions for reversible control of gene expression in neurons. In the Ju...cations in experimental research that makes use of reversible gene expression tools to switch genes on and off. Neuroscientists need such gene switches to investi...Weizmann Institute scientists develop a general 'control switch' for protein activity
...g the rate of protein activity in an immediate and reversible manner can be of great value....Heart failure: Intervention possibilities from imaging programmed cell loss
...arch is significant since cell loss is potentially reversible and earlier intervention could delay the development of cardiomyopathy or heart muscle disease," noted Hofstra. He indicated that additional research is needed since the study was performed on a small group of heart patients. "Heart failure is a m...Genetic hearing loss may be reversible without gene therapy
...on of genetically caused deafness in humans may be reversible by compensating for a missing protein, based on discoveries in mice. Emory University researchers have found that in mice, increasing the amount of the protein connexin26 in the ear's cochlea compensates for an absence of another protein, connexin3...Prion disease treatable if caught early
... Mallucci and colleagues. "Our findings of early reversible neurophysiological and cognitive deficits occurring prior to neuronal loss open new avenues in the prion field," they wrote. "To date, prion infection in mice has conventionally been diagnosed when motor deficits reflect advanced neurodegeneration. N...Fish can determine their social rank by observation alone, study finds
...nference, the Stanford team took advantage of this reversible change in appearance by staging a series of short fights between male cichlids of equal size. In the experiment, fish that lost their eyebar during one-on-one combat were declared the loser. After each bout, the loser was separated from his oppone...Profiling of cancer genes may lead to better and earlier detection
... Assessment Program. "Methylation is potentially a reversible change and there may be some interventions that would effectively reduce the risk of several types of cancer simultaneously."...PET imaging shows young smokers quick benefit of quitting
...PET study that shows abnormal coronary function is reversible after only one month of smoking cessation," said Nagara Tamaki, a professor and chair of the nuclear medicine department at Hokkaido University in Sapporo, Japan. "Smoking cessation normalized abnormal coronary artery function, thus supporting its va...One signal elicits thousands of answers
...on via protein modifications, most importantly the reversible attachment of phosphate, the so-called protein phosphorylation. Researchers at the Max Planck Institute of Biochemistry in Martinsried have now developed a technology to identify and quantify the specific sites in proteins that get phosphorylated in ...New study shows how genetic repair mechanism helps seal DNA breaks
...and processes such as cancer," said Tainer. "These reversible complexes are also critical to efforts in understanding and controlling microbial responses and pathways." Prior to the experiment, the scientists expected that DNA ligase would curl up in complex with the ring-shaped PCNA protein. However, results...Male contraceptive study expands to 4 US cities
... little more high-tech. If it turns out to be more reversible than vasectomy, so much the better. I only wish it were available closer to home." Men's attitudes John's strong desire to participate in contraception is far from unique. Condoms and vasectomy together account for one quarter to one third of c...Animals resistant to drunken behavior offer clues to alcoholism's roots
...es in the cytoskeleton of neurons. Those rapid and reversible responses to ethanol seen in normal mice were lacking in the Eps8-deficient animals. By contrast, Heberlein's group set out to find genes involved in drug responses, said Adrian Rothenfluh, also of UCSF. Their genetic screen of many fly mutants unc...NHGRI aims to make DNA sequencing faster, more cost effective
...r goal is to improve the chemical subunits, called reversible terminators, for use in a system that will ultimately be used to sequence DNA templates in high-density arrays, using a sensitive fluorescence detection system. Steven Jeffrey Gordon, Ph.D., Intelligent Bio-Systems, Inc., Worcester, Mass.,$425,00......tem cells proliferate until after birth and show a reversible phase-specific engraftment defect AUTHOR CONTACT: Connie J. Eaves Terry Fox Laboratory, Vancouver, British Columbia, Canada. Phone: (604) 675-8122; Fax: (604) 877-0712; E-mail: ceaves@bccrc.ca . View the PDF of this article at: https://www.the-jc...