Tag: "ribosome" at biology news
GlaxoSmithKline awards $250,000 in research grants for research on drug therapies for HIV/AIDS
...velopment Research Grant for his study of internal ribosome
entry sites (IRESs), which are highly structured regions present in the RNA of some viruses. IRES regions are believed to direct the synthesis of viral proteins in host cells. Dr. Robertson and his colleagues have discovered a target site within the...
An unusual RNA structure in the SARS virus offers a promising target for antiviral drugs
...angle bend in RNA," Noller said. This part of the ribosome
and the proteins that bind to it are involved in the regulation of protein synthesis, leading Scott and his coauthors to hypothesize that the s2m RNA, by mimicking the ribosomal binding site, may serve to hijack the host cell's protein-synthesis mach...
Scientists discover unique microbe in California's largest lake
...he foreign DNA encodes a structural feature of the ribosome
that makes large and precise movements during prot... genetic exchange has in fact had consequences for ribosome
function in these bacteria. The new species of Acaryochloris is the latest in a series of new orga...
Timing is everything: First step in protein building revealed
... As a result, Lorsch studies the timing of how the ribosome
complex itself assembles and how other factors com...to build proteins, the workhorses of cells. If the ribosome
doesn't start in the right place along a gene's instructions, it will make the wrong protein, which ...
Yale scientists 'see' basis of antibiotic resistance
... of the macrolide ring, causing it to back off the ribosome
by an Angstrom or so," said Steitz. The change of...se to the high-resolution crystal structure of the ribosome
they revealed. Rib-X is utilizing this information to create new antibiotics; they project Phase-I t...
Researchers make gains in understanding antibiotic resistance
... center, of the large subunit of the ribosome. The ribosome
is the molecular machine responsible for translati...tibiotics bound to a mutated version of the Hma ribosome
that corresponds to a form found in pathogenic bacteria. Their studies revealed details of erythromy...
Textbook explanation of mRNA translation may need rethinking
...litates tRNA translocation in bacteria, enters the ribosome
bound to a different guanine nucleotide than previously thought GDP, not GTP. The ribosome
itself then seems to act as the guanine-nucleotide exchange factor, not some as-yet-unidentified fac...
North & South American researchers find architectural abnormalities in T. cruzi ribosome
...lbany, New York, who had pioneered the analysis of ribosome
structures by a method he developed for three-dime...about the structure of the parasite's ribosome. A ribosome
is basically a double ball made mostly of RNA and over 50 proteins. The balls, which are of unequal ...
Evolution of life on Earth may hold key to finding life in outer space
...lution of Life" is to understand when and how the ribosome
(or cellular protein synthesis machinery) came int... group are examining the various components of the ribosome
machinery trying to learn what parts came first and what was added later. "Since many of the compo...
A double punch for female survival
...o create proteins. "Cells build a machine called a ribosome
on an mRNA to transform its information into prote...cks the construction of the docking bridge for the ribosome
at the head end." The second copy of SXL has a different function, he says. Single control mechanism...
Life's origins were easier than was thought
... are called ribozymes (a contraction of the words ribosome
and enzyme). But there is an important obstacle to the theory of ribozymes as the origin of life: they could not be very large in length as they would not be able to correct the replication errors (mutations). Therefore they were unable to contain en...
Study finds protein is required for human chromosome production
...formation from the DNA (inside the nucleus) to the ribosome
(outside the nucleus), is called messenger RNA. RNA that is not cut by CPSF73 is destroyed in the nucleus and never becomes messenger RNA, said Dr. William Marzluff, senior author of the study and Kenan distinguished professor of biochemistry and bio...
Study provides insight into cellular defenses against genetic mutation
... mRNAs linked to CBP80 are targeted for NMD when a ribosome
finds an early stop codon. Most recently, the Nature paper demonstrated for the first time that CBP80 works by activating a protein factor known to drive NMD called human up-frameshift (hUpf) protein 1. A Matter of Spacing Immature mRNA is made of...
Study findings offer potential new targets for antibiotics
...s thought that there may be additional places in a ribosome
that future antibiotics could affect, places that ...ct that there actually are other "hot spots" on a ribosome
that could act as potential targets for antibiotics the researchers first introduced a mutated copy...
New and sharper X-rays of cell's ribosome could lead to better antibiotics
...es. The high-resolution snapshots of the bacterial ribosome
were captured by scientists at the University of C...cules. The new, high-resolution data on the intact ribosome
allows researchers to build more detailed and more realistic models of the ribosome
that until now w...
Columbia University awards 2005 Horwitz Prize to Israeli structural biologist
... will be honored for her structural studies of the ribosome
the tiny but complex molecular machine responsible for the production of proteins, the building blocks of life, within cells. "We are pleased to continue our Horwitz tradition by awarding this year's prize to Ada Yonath," said David Hirsh, Ph.D., ...
Zooming in on the protein-conducting channel
...x comprising the PCC from E. coli attached to a ribosome
that contained a newly forming protein segment. The ribosome
is the massive protein-RNA complex that constitutes the cell's protein-making machinery. Mitra explo...
Biotechnology's newest chemical tool
...application might be to label various sites in the ribosome
-- the RNA-based site of protein production -- with bright fluorophores using appropriate RNA methyltransferases, enabling real-time dynamic studies of the complicated mechanism of protein translation....
Picking particles faster than one at a time
... can be wrecked by jamming their ribosomes, if the ribosome
structure is known in detail. Single-particle reco...by using it to pick images from among over 130,000 ribosome
particles in 55 micrographs provided by the Wadsworth Center of the New York State Department of Hea...
New insights into protein synthesis and Hepatitis C infections
...ls begins with the loading of mRNA onto the small ribosome
subunit, 40S, which is, in part, one of the respon...nd). By drawing the mRNA's 5'-end cap through the ribosome
entry site and towards the exit, eIF3 ensures the mRNA is properly positioned for its genetic code t...