Nilotinib appears to help chronic myelogenous leukemia patients when standard care fails
...r side effects than Gleevec, which is considered a safe drug, some patients in this trial were found to have abnormal electrical activity in their hearts, and one patient experienced two cardiac events. "We believe this issue is manageable with the right dose of nilotinib and with careful monitoring, but ...Researchers attack tumor cells by exploiting dependency on sugar metabolism
...t inhibition of LDH-A may represent a rational and safe strategy for treatment of cancer. "Because individuals with complete hereditary deficiency of LDH-A do not show any symptoms under ordinary circumstances, the genetic data suggest that inhibition of LDH-A activity may represent a relatively nontoxic ...A sweet solution for Alzheimer's disease?
...nervous system. Even if scyllo-inositol does prove safe and effective in humans, patients will likely still need drugs designed to attack other aspects of Alzheimer's pathology, such as tau neurofibrillary tangles, St George-Hyslop said. "Alzheimer's disease is probably going to be treated by a cocktail o...Gene therapy injected into the brains' of mice with Huntington's disease
...niversity Medical Center, which was reported to be safe and well tolerated in PD patients at the American Association of Neurology meeting last spring. Initial efficacy results of this Phase I trial are expected to be presented this fall and a double-blinded, controlled Phase II trail in PD patients is p...Universal design tackles little things with big impact
...ity," Bix said. "Why should the disabled have less safe packages than I do? Is it an easy answer? No, but we can think creatively and do more."...Sandia tool speeds up environmental cleanup, reopening of contaminated facilities
...eptance for declaring a facility to be "clean" and safe to reoccupy. Sophisticated yet easy-to-use hardware "Collecting samples from a contaminated facility is currently a painstaking, time-consuming process for HazMat responders," says Jane Ann Lamph, a Sandia engineer and business development associate ...Biological diversity and human health; Rapid autopsy program; Snake bites and more
...l collaboration is needed to produce effective and safe antivenoms in the regions where they are not available. The authors argue that the World Health Organization would be best placed to play a coordinating role in such a collaboration, which should involve national and regional health organisations an...Infant bone growth and maternal vitamin D levels during pregnancy influence future fracture risk
...n further research, he said. "We think it would be safe but we can't recommend that type of intervention until we study it further."...JCI table of contents, June 1, 2006
...mia in diabetes will likely remain a problem until safe and effective methods are developed that would offer insulin replacement based on plasma glucose concentration. TITLE: Corticotrophin-releasing factor receptors within the ventromedial hypothalamus regulate hypoglycemia-induced hormonal counterregul...Virginia Tech student selected to meet Nobel Laureates
...anium," said Wigginton. "It could potentially be a safe and cost effective means of environmental remediation. I am studying some of the underlying mechanisms of that process." Wigginton looks forward to discussing the research with Nobel laureate Marcus. "I also want to talk to other laureates about how...For Stanford scientists, RNAi gene therapy takes two steps forward, one step back
... made by the therapeutic gene would continue to be safe if it existed in high levels in a tissue over long periods of time. Instead of proving the safety of RNAi gene therapy, the pair found that persistent, high levels of the shRNA made the mice sick, and in some cases the mice even died. The problem, it...Gene therapy for chicken model of childhood blindness
...rchers would need to demonstrate that the virus is safe in humans, and additional studies would need to be done to improve the virus and determine the dose required to achieve long term restoration of sight. In addition, it will be important to examine existing patients to determine when therapeutic inter...Injecting stem cells from a woman's own muscle may effectively treat urinary incontinence
... now have preliminary evidence that stem cells are safe to use and appear to improve female stress urinary incontinence." Previous studies at the University of Pittsburgh School of Medicine in animal models with SUI demonstrated that injecting stem cells into the urethral muscles increases leak point pres...Giant deep-sea tubeworm's meal ticket comes in as a skin infection
...ing worm indefinitely. In return thebacteria get a safe habitat and a reliablesource of food. "The symbiont, and only the symbiont, iscapable of invading the skin of the tubewormlarvae. It migrates through several layers oftissue towards the interior of the host, andinto the future trophosome," Brightexpl...Acetaminophen safe to use after heart attack but doesn't protect the heart
BETHESDA, MD. Acetaminophen is safe to use as a pain reliever and fever reducer after ...eart attacks need to know which pain relievers are safe to use. Some studies have suggested there is an increased risk of stroke and heart attack among pati...Federal testing for mad cow disease a failure, law review editor says
...1913 Virus-Serum-Toxin Act, intended to assure the safe supply of animal vaccines, as its authority for barring private testing. Berlowitz called the action a ruse to protect the agency and the beef industry from a public outcry that would take place if more cases of mad cow disease were found. "In its 93...Plants tell caterpillars when it's safe to forage
...g while those released at night indicate that it's safe to come out and eat. Just as parasitic wasps use plant volatiles to home in on potential victims, caterpillars use variations in their host plant's volatile production to reduce the risk of unpleasant encounters with wasps. Now that they've establish...Unique dual target specificity of kinase inhibitor key for success against cancer
...inatorial inhibition of mTOR and p110 represents a safe and effective therapy in the treatment of cancers driven by aberrant signaling through PI3 kinase," says Dr. Weiss. "Glioma represents the most common primary brain tumor, and there are no curative medical therapies. Ultimately, we believe that PI-10...In undersea habitat, aquanauts learn about teamwork and task performance for the moon and Mars
...t maintain vigilance and work together to ensure a safe and successful mission. Between daily living, telemedicine activities and moon-walking simulations, participants in the NASA Extreme Environment Mission Operations (NEEMO) 9 project helped National Space Biomedical Research Institute (NSBRI) research......tance, but it is only the first step in creating a safe and effective herbal trade in the United States."...