Tag: "sarcoma" at biology news
Bishop named winner of National Medal of Science
... at UCSF in 1968, he shifted his attention to Rous sarcoma
virus, hoping to explore the fundamental mechanisms of tumorigenesis. In 1970, he was joined by Harold Varmus. Together, they directed the research that led to the discovery of proto-oncogenes -- normal genes that can be converted to cancer genes by ...
Novel gene-silencing nanoparticles shown to inhibit Ewing's sarcoma
...into tumor cells has been shown to inhibit Ewing's sarcoma
in an animal model of the disease. In this classic...gene called EWS-FLI1 that's active only in Ewing's sarcoma
tumors. Once inside these cells, the genetic machinery of the tumor cells are effectively silenced o...
Counting cells in blood samples may predict cancer treatment's effectiveness
...phase II trial, patients with advanced soft tissue sarcoma
were randomly assigned to one of two doses of ABT-...reatment. The study looked at people with advanced sarcoma
that had metastasized, or spread to other parts of the body. Survival rates for this stage of sarcom...
Several minute intermediate stage in virus-cell fusion discovered; opportunity for drug development
...al viruses fusing with a host cell membrane. Avian sarcoma
and leukosis virus (ASLV), a virus that is in the same class as HIV, was used in the study. The researchers discovered that once the virus fuses with the host cell membrane the hole, or pore, through which the virus unloads its deadly genetic cargo...
Other highlights in the July 6 JNCI
...y cavity lymphomas, and Castleman disease. Kaposi sarcoma
occurs in about 0.2% to 0.5% of patients after solid organ transplantation but is rare among bone marrow transplant recipients. Whether HHV-8 can be transmitted through blood has been uncertain, and it has not been known whether bone marrow transplan...
Reversal of role for a viral protein associated with the development of lymphoma
... end of 2005. HHV8, originally linked to Kaposi's sarcoma
the most common cancer among AIDS patients also is associated with lymphoid diseases such as primary effusion lymphoma and multicentric Castleman's disease, a noncancerous but severe disorder characterized by enlargement of the lymph nodes. Recent s...
ECCO 13 - Sunitinib prolongs survival in GIST patients after imatinib mesylate failure
... (GISTs) are an extremely rare type of soft tissue sarcoma
that arise from cells of the stroma, the connectiv...nd cartilage. GISTs are a rare type of soft tissue sarcoma
and 60% occur in the stomach, but they can occur anywhere along the length of the digestive system f...
ESMO International Symposium on Prostate Cancer
...be in Antwerp, Belgium, 10-11 March 2006.An EIS on sarcoma
and GIST will be in Milan, Italy, 17-18 May 2006. Special features of the EIS symposia: 2-day program Educational sessions by renowned experts in the specific cancer type Program schedule reflecting the chronology of the disease, from prevention ...
New research identifies specific teenage and young adult cancers and points to possible causes
...imilar age of onset pattern is also seen for Ewing sarcoma
of bone and the causal mechanisms may be related. "Most testicular cancers, at whatever age, are germ cell tumours and it is well known that these show a peak incidence in young adult males. In contrast, most ovarian cancers are carcinomas (cancers ...
Inhibition of iron-metabolizing enzyme reduces tumor growth
...enzyme involved in iron metabolism, reduces Kaposi sarcoma
tumor growth. This discovery could result in the p...iochemistry and Molecular Biology journal. Kaposi sarcoma
is the most frequent tumor in AIDS patients and is caused by infection of the patients with the Kapo...
ESMO International Symposium on Sarcoma and GIST
...re revolutionizing medical oncology. In principle, sarcoma
tumors may be among the most treatable with these ...erviews and briefings on the topic. The meeting on sarcoma
and GIST is the second EIS Symposium ESMO has held this year. In March, the first symposium on prost...
Scientists tie several cancers to common 'oncogene engine'
... a dangerous type of soft-tissue tumor clear cell sarcoma
that develops near muscles and tendons in teenage...possibility of MITF involvement because clear cell sarcoma
tumors are sometimes pigmented a process requiring the MITF transcription factor. In this form of s...
18th EORTC -- NCI -- AACR Symposium
...ork better together than alone in tests on Ewing's sarcoma
in mice patient trials planned...
Drug that interrupts a key stage of cell division shows promise for advanced solid tumors
... of solid tumours: colorectal (9), pancreatic (3), sarcoma
(5), ovarian (2), kidney (2), prostate (2), cancer of the bile ducts (2), oesophageal (3) and eight others. They tested seven different dose levels of the drug (measured in milligrams per squared metre of body surface area (mg/m2)). Two patients c...
An AIDS-related virus tricks cells to become tumors, new Penn study finds
...ers new potential strategies for treating Kaposi's sarcoma
and other cancers associated with viruses. KSHV ... patients are at high risk for developing Kaposi's sarcoma
and another cancer called primary effusion lymphoma. The study describes how a KSHV-encoded prote...
Synthetic peptide targets latent papilloma virus infections
...ukemia called Burkitt's leukemia, and the Kaposi's sarcoma
virus, which can develop to cancer in those with AIDS....
JCI table of contents: March 15, 2007
... causes tumor regression Infection with Kaposi's sarcoma
virus (KSHV) can cause 3 types of tumor, including primary effusion lymphoma (PEL). Although KSHV has been known to cause tumors for many years, there are no effective therapies for the treatment of KSHV-induced tumors. Now, researchers from the Univ...
JCI table of contents -- April 5, 2007
...sms underlying EWS-related cancers. TITLE: Ewing sarcoma
gene EWS is essential for meiosis and B lymphocyte development AUTHOR CONTACT: Sean Bong Lee National Institutes of Health, Bethesda, Maryland, USA. Phone: (301) 496-9739; Fax: (301) 480-0638; E-mail: seanL@intra.niddk.nih.gov . View the PDF of ...
Progress against sarcoma
...sts have engineered mice that can develop synovial sarcoma
a significant early step toward developing new tr...stricken mice were used to determine that synovial sarcoma
develops in muscle cell precursors known as myoblasts, the researchers report in the April issue of ...
Mouse model advances understanding of synovial sarcoma
A mouse model for synovial sarcoma
has enabled scientists to make tremendous progress...rategies for this often lethal cancer. Synovial sarcoma
is associated with expression of a chimeric fusion protein called SYT-SSX. Dr. Mario R. Capecchi, fr...