Stem cell therapy rescues motor neurons in ALS model
...ying neurons characteristic of amyotrophic lateral sclerosis (ALS), a fatal neuromuscular disorder also known as Lou Gehrig's disease. The new work, conducted in a rat model and reported today (July 31) in the online, open-access journal from the Public Library of Science, PLoS ONE, shows that stem cells eng...Geisinger scientist seeks cure for Lou Gehrig's disease, creating device to find treatment
...Lou Gehrig's disease-or ALS or amyotrophic lateral sclerosis is a fatal neurodegenerative condition that affects nerve cells in the brain and the spinal cord. As many as 20,000 Americans suffer from ALS and about 5,000 people in the U.S. are diagnosed with the disease each year, according to the National Insti...Research teams uncover risk genes for multiple sclerosis
... the main genetic pathway associated with multiple sclerosis (MS), while also uncovering new genetic variations in the disease and suggesting a possible link between MS and other autoimmune diseases. The first study, led by an international consortium of clinical scientists and genomics experts, incorporates...First new multiple sclerosis gene found in 30 years
...uiding future research into therapies for multiple sclerosis in what its discoverers say is the first major gen...t are already known to be associated with multiple sclerosis only explain less than half of the total genetic basis for the disease, said Simon Gregory, Ph.D., m...After a decades-long search, scientists identify new genetic risk factors for multiple sclerosis
... genes that influence the risk of getting multiple sclerosis (MS) data sought since the discovery of the only other known MS susceptibility gene decades ago. The findings could shed new light on what causes MS a puzzling mix of genes, environment and immunity and on potential treatments for at least 350,00...Risk genes for multiple sclerosis uncovered
...ed new genetic variations associated with multiple sclerosis (MS), findings that suggest a possible link between MS and other autoimmune diseases. The study, led by an international consortium of clinical scientists and genomics experts, is the first comprehensive study investigating the genetic basis of MS. F...JCI table of contents -- July 26, 2007
... tolerance Autoimmune diseases such as multiple sclerosis and arthritis result from the bodys immune system attacking its own tissues or self antigens. Therefore, researchers have long desired to understand how a state of immune tolerance (the inability to mount an immune response against an antigen) may be...JCI table of contents: July 12, 2007
...une response in multiple sclerosis? In multiple sclerosis (MS), the myelin that surrounds the axons of nerve cells is attacked by the bodys own T cells, resulting in slowed and disrupted nerve impulses and, ultimately, axon loss. Myelin basic protein (MBP) is a major component of the myelin sheath and when ...Chronic fatigue -- clues in the blood
...an diseases from rheumatoid arthritis and multiple sclerosis through to schizophrenia....New clue why MS affects African-Americans differently than Caucasians
...have been found in African Americans with multiple sclerosis (MS) compared to Caucasians, possibly offering a clue why African Americans experience more disability with MS than Caucasians, according to a study published in the July 3, 2007, issue of Neurology, the medical journal of the American Academy of Neu...Antibody linked to MS significantly higher in spinal fluid of blacks
...requently used as a diagnostic marker for multiple sclerosis (MS) is present at greater levels in the cerebrospinal fluid of blacks with MS than Caucasians with the disease.The findings suggest that genetic differences among ethnic groups contribute to changes in the immune system, affecting susceptibility to ...Weizmann scientists discover a new line of communication between nervous system cells
... host of neurological diseases, including multiple sclerosis (MS) and several neuropathies, the protective covering surrounding the nerves an insulating material called myelin is damaged. Scientists at the Weizmann Institute of Science have now discovered an important new line of communication between nervo...Largest ever study of genetics of common diseases published today
...reast cancer, autoimmune thyroid disease, multiple sclerosis and ankylosing spondylitis. The results are expected later this year....Story ideas from the Journal of Biological Chemistry
...may better explain what causes amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's Disease. ALS is characterized by the death of neurons that control voluntary muscles, leading to muscle weakness and atrophy. Around 25 percent of the familial forms of the disease forms that occurs repeatedly in ...$5M gift will attack Lou Gehrig's disease from all angles
... Taubman lost a good friend to amyotrophic lateral sclerosis a horrifying fatal disease thats better known as Lou Gehrigs disease or ALS. The memory of watching New York Sen. Jacob Javits slowly succumb to the nerve-killing condition has never left Mr. Taubmans mind. And that memory has motivated him to su...News tips from the Journal of Neuroscience
...nces E. Jensen, and David J. Kwiatkowski Tuberous sclerosis (TSC) arises from mutations in TSC1 and TSC2 , genes that encode tumor suppressor proteins. Cortical tubers in the brain parenchyma, a pathological hallmark of the disease, contain enlarged, dysplastic neurons, accompanied by neurological symptoms...Natural immune-control system may aid treatment of autoimmune disease and tissue rejection
...sponsible for autoimmune diseases such as multiple sclerosis and for the rejection of transplanted organs and tissues, scientists at Dana-Farber Cancer Institute report in a study in the May issue of the journal Immunity and which will be available online on May 17, 12 noon ET. Because the technique utilizes...Testosterone may help men with multiple sclerosis
...le hormone estriol combats the effects of multiple sclerosis (MS) in women, a just completed pilot study at UCL..., the most common form of the disease. Multiple sclerosis is a progressive disease involving the immune and central nervous systems. MS and many other autoimm...NIH awards $7.39 million to Burnham neurobiologists
...evance to demyelinating diseases, such as multiple sclerosis and neuropathies," said project director Yu Yamagu...ve fibers to conduct electrical signals. Multiple sclerosis is the most well known of the so-called demyelinating diseases. "With this funding, we expect to re......ein as a potential therapeutic target for multiple sclerosis because de-activating it protects nerve fibers from damage. OHSU researchers, working with colleagues at the Portland Veterans Affairs Medical Center and the University of Padova in Italy, have shown that genetically inactivating a protein called c...