New tuberculosis antibiotic may shorten treatment time, fight drug-resistant strains
...hnson. The research team identified this family by screening a large number of compounds from its chemical "library" to see what effects the compounds had on M. smegmatis (used as a surrogate for M. tuberculosis because it's nonpathogenic). The most promising member of the DARQ family was a compound called R20...False positive screening for cancer found to be frequent and costly
PHILADELPHIA--Cancer screening tests can frequently produce false positive outcom... Among 1,087 individuals participating in a cancer screening trial who received a battery of tests for prostate, ovarian, colorectal and lung cancer, 43 percent ...Femtosecond laser technique opens new opportunities for research on neural regeneration
...n to regenerate. In the worm, we can do systematic screening of large numbers of genes, and of drugs and other small molecules as well, to ask how they affect the process of regeneration," Chisholm said. The researchers reported their findings in a paper published in the December 16 issue of the journal Natu...Screening for genetic disorders: Need to avoid anxiety
...enetic science is still in its infancy, population screening exposes people to tentative projections of risk wi... and advice. Professor Atkinson said: "Population screening can create a considerable burden of counselling and follow-up for primary and secondary health care ...VA patients get better chronic, preventive care than similar US adults
...ventive care, such as pneumococcal vaccination and screening for colorectal cancer, showed even greater differences; 64 percent of indicated preventive care was delivered to VA patients compared with 44 percent in the national sample. Generally, VA patients received consistently better care across the entire s...First 'atlas' of key brain genes could speed research on cancer, neurological diseases
...rn problem of cancer pain: He and his students are screening the atlas for transcription factors that regulate development of the neurons that generate the severe pain that is a common symptom of metastatic tumors....Protein in urine may warn of preeclampsia risk in pregnant women
...t could help pave the way for the development of a screening test for this potentially life-threatening disease...t could provide a less invasive and less expensive screening tool to detect preeclampsia at an early stage. Because the sFlt1 molecule is too large to be filter...Scientists discover key genetic factor in determining HIV/AIDS risk
...ntists believe that this discovery could lead to a screening test that identifies people who have a higher or lower susceptibility to HIV/AIDS, potentially enabling clinicians to adapt treatment regimens, vaccine trials and other studies accordingly. The research appears Jan. 6 in Science Express, an online pu...Development of portable infectious disease detector
...le are joining forces to develop "high-throughput" screening systems that can determine the biological activity of large numbers of compounds with extreme rapidity and so could have a major impact on the drug discovery process. Fifteen years ago a number of start-up companies were created to make the goal of c...Anti-seizure drugs slow aging in worms
...e. The anti-aging effect was revealed in a random screening of 19 drugs approved for treating a variety of disorders in humans. "We didn't start with a hypothesis about what causes aging," says senior author Kerry Kornfeld, M.D., Ph.D., associate professor of molecular biology and pharmacology. "We wanted to ...Genetic testing for Parkinson's disease on the horizon
... LRRK2 mutation in familial Parkinson's disease by screening the DNA of patients and controls. Of 767 affected individuals from 358 families, 35 patients from 20 different families had one or two copies of the mutation and had typical clinical features of Parkinson's disease. Their results suggest that the sin...New genetic mutation linked to Parkinson's disease
... the discovery has a broad implication for genetic screening for the disease. "Our results suggest that the mutation we have studied is the most common cause of Parkinson's disease identified to date," said Dr. Foroud. "While a great deal of work remains to be done, it is clear that any future genetic testing...Study identifies the most common genetic cause of Parkinson's disease
...nding opens the door to the possibility of genetic screening for the LRRK2 gene mutation, which is believed to be the most common genetic cause of inherited Parkinson's disease identified to date. The study, conducted by William C. Nichols, PhD, a geneticist at Cincinnati Children's Hospital Medical Center, i...Plant protein mimics hormone that mitigates diabetes and obesity
...The research has the potential to lead to a simple screening system for developing new drugs to treat these and several other human diseases, including some forms of cancer, said Ray Bressan, distinguished professor of horticulture and one of the study's authors. The study also raises questions about the human...Mayo Clinic researchers discover new kind of heart failure gene
...r findings may broaden the indications for genetic screening of SCN5A beyond isolated rhythm disorders," says Dr. Olson. "Since these variations hinder sodium transport, it may be wise to avoid using sodium channel-blocking drugs in heart failure patients with SCN5A mutations, because those drugs may make the ...Molecular probes for biology research and drug discovery
... be pursued in Dortmund and Mlheim. The biological screening and evaluation of the developed molecular tools will be performed in Kln for plants and in Dresden, Martinsried, Mnchen and Dortmund for mammalian cell lines. "We are living in the "post genomics" age, which means that we know and have access to the ...Calcium may protect women from cancer
...tration Project (BCDDP), which was a breast cancer screening program conducted jointly by NCI and the American Cancer Society between 1973-1980. The women initially completed a 62-item questionnaire that assessed their usual daily diet, lifestyle habits and patterns, and use of over-the-counter nonsteroidal an...Racial groupings match genetic profiles, Stanford study finds
...rs know which patients may need additional disease screening or should receive one treatment over another. But recently some researchers have moved to examining genetic differences between participants rather than relying on race and ethnicity. Their reasoning is that genetic differences may be a more precise ...Wider use of simpler cervical cancer screening could benefit women in developing countries
...easy, inexpensive method using ordinary vinegar in screening women for cervical cancer could be applied in more...alth's National Cancer Institute. He said that the screening method using vinegar known as VIA (the acronym for visual inspection with acetic acid) should be s......oblem. The researchers used random mutagenesis and screening to find animals with hematopoiesis defects, and they used genetics to identify the causative gene. One line mapped to a mutation in the gene c-Myb, which has a known role in regulation of blood formation. Interestingly, they found that c-Myb is not r...