Compound inhibits one critical pathway in breast cancer growth
...ould physically test in the lab. When the computer screening process ended, the researchers tested the 100 top compounds. They tested these compounds on human breast cancer cells in order to find which one best stopped the constant Stat3 activation. STA-21 appeared to be the best inhibitor of Stat3 activity. "...Gene variant increases risk of age-related macular degeneration
...The team identified the disease-related gene after screening 182 families affected by AMD and 495 other individuals with the condition. The researchers will report their findings in a forthcoming issue of Science (published online March 10, 2005, in Science Express). The genetic advance sheds light on the me...To control germs, scientists deploy tiny agents provocateurs
...l chemistry techniques, Blackwell and her team are screening through hundreds of molecules at a time. The researchers have so far unveiled three promising organic compounds that seemingly quell bacterial signaling....Scientists identify molecule that regulates well-known tumor suppressor
...niversity of Toronto and colleagues used a genetic screening method in fruit flies and identified the molecule DJ-1 as a PTEN suppressor. In studies with mammalian cells, low levels of DJ-1 correlated with decreased PKB/Akt activity, while increased DJ-1 led to activation of PKB/Akt and enhanced cell survival....Researchers discover chemical compounds that affect plant growth
...y the binding of a chemical, which can be found by screening large libraries for compounds that specifically affect a measurable process." The scientists found 219 chemicals that affected the direction of plant growth due to gravity. Further screens reduced this number to 34, then down to 4 chemicals, which af...Consortium to create comprehensive tools for uncovering the functions of human, mouse genes
...will create methods for performing high-throughput screening with the entire library. "We are pleased to be a p...edicines." "The ability to perform high-throughput screening with validated RNAi reagents will provide the ability to systematically identify the genes underlyin...Short-term social stress may benefit immune response to infection
...nsitivity tests and fluorescently-labeled antibody screening revealed that the mice that had been stressed prior to receiving the influenza infection had a stronger immune reaction to the infection, with markedly higher numbers of two types of T cells specific for influenza. When exposed to the influenza virus...Automated imaging screen reveals promising drug candidates
...van Shokat and colleagues report a high-throughput screening method that substantially narrows the field of can...ted the power of using high-throughput image-based screening to identify small molecules both for probing cell biology and for identifying promising drug candida...Multiple-drug resistant gene expression pattern predicts treatment outcome for pediatric leukemia
...spital and colleagues used a comprehensive genetic screening technique to search for genes that are differentially expressed in ALL cells that demonstrated cross-resistance to two or more commonly used chemotherapeutic agents. The researchers identified several genes that were differentially expressed in ALL c...Study reveals dramatic difference between breast cancers in US and Africa
...ver 50 have less risk than Caucasians. Most of the screening guidelines in this country are based on studies that primarily looked at Caucasians, said Olopade. "We need to reconsider how to screen for a disease that is less common but starts sooner and moves faster. Obviously an annual mammogram beginning at 5...Biomarkers isolated from saliva successfully predict oral and breast cancer
...g been a goal of scientists seeking quick and easy screening tools that could be done in a doctor's office. The search for such tests, however, has been stalled until recently with the advance of several emerging technologies including improved methods to identify, collect, preserve and amplify genetic materia...Mitochondrial DNA variants linked to renal, prostate cancer
... most conventional, nationwide recommendations for screening suggest that high risk groups get screened earlier... is the essence of what we suggest. We would begin screening with serum PSA and digital rectal exams say at 40 or 45 instead of 50. If you believe in screening f...Inherited variations in mitochondrial DNA linked to renal and prostate cancer
...g this large number of at-risk individuals so that screening can be initiated for early detection and prevention."...New tumor suppressor gene linked to cancer predisposition
...te a test for this gene and others into a simple screening tool that may reveal the extent to which a person is at risk for developing cancer." Calin says such tests could mean earlier detection of disease "which is not only good health, but good business."...Researchers identify protein crucial for survival of Lyme-disease bacterium
...a lead author of the study, found the bptA gene by screening a number of candidate genes he thought might be affecting the survivability of Bb within its hosts. The research team had hypothesized that the elimination of the gene would somehow impact the pathogenesis of Lyme disease in mammals, but they found n...Hereditary colorectal cancer risk lowered in those without certain gene defect
...an MMR defect has been unknown, as are appropriate screening guidelines. Noralane M. Lindor, M.D., of the Mayo Clinic, Rochester, Minn., and colleagues identified 161 families in North America and Germany meeting AC-I criteria and analyzed the family history for cancer incidences. The families were stratifie...ASU researcher creates novel 'bioelectronic signatures' to detect DNA mutations
... small, portable, electronic devices for the rapid screening and identification of genes that harbor disease. Joseph Wang, director of the Center for Bioelectronics and Biosensors at the Biodesign Institute at ASU, led a team that successfully merged efforts in the fields of biosensors, electronics, and nanote...New tool reveals secrets of migrating cells
...der. "To pass into the medulla they have to pass a screening test called positive selection," Witt said. "Once they do, the cells move very directly at a very fast speed inward toward the medulla, adopting a polarized shape characteristic of migrating cells." While Witt and Robey continue their two-photon imag...UCLA scientists pinpoint region of autism gene on chromosome 17
...ation. This is the first step to providing better screening and potential treatments for autism. AUTHORS Dr. Dan Geschwind, associate professor of neurology; Rita Cantor, adjunct professor of human genetics; Stan Nelson, professor of human genetics; Jennifer Stone, graduate student researcher, at the David ......overed, if our observations are confirmed, genetic screening could become an important part of our pre-operative evaluation of heart surgery patients," said Duke anesthesiologist Ian Welsby, M.D., lead author of a study to be published in the June edition of the Journal of Thrombosis and Haemostasis but appear...