Check colon tumors for signs of syndrome, study suggests
...ies. As the next step before proposing nation-wide screening for Lynch syndrome the OSU researchers are planning to implement their screening strategy Ohio-wide. Testing all colon tumors for MSI is becoming important because patients with tu...Scientists take aim at virulent bacteria by decoding machinery of key control enzyme
...tinue their research using structure-based virtual screening techniques and high throughput equipment to screen for potential inhibitor compounds against the Dam enzyme....Gene implicated in chronic kidney disease
...s narrowed that span to the single gene, TRPC6, by screening 106 members of the seven-generation, 600-member family, including individuals with and without the disease. In this family, all members with FSGS carry a mutation in the TRPC6 gene, the team reported. Further study of the gene variant in kidney cell ...By creating molecular 'bridge,' scientists change function of a protein
...tural evolution in a test tube but may require the screening of an astronomical number of mutants for the creation of new protein functions. "We now provide one possible solution to a long-lasting barrier that is important in the protein engineering area -- that is the creation of the new protein functions," Z...PNAS highlights for the week of May 9 - 13
...Ovarian Cancer Researchers have developed a blood screening test that could help catch ovarian cancer in its e...ced stages. Clinicians currently have no sensitive screening method because the disease shows few symptoms in its early stages. David Ward and colleagues develop...Research on antibiotics receives historical recognition
...chatz, a graduate student of Waksman's, using soil screening methods developed by Waksman. This deliberate search for chemotherapeutic agents contrasts with the discovery of penicillin, which came through a chance observation by Alexander Fleming, who noted that a mold contaminant on a Petri dish culture had i...Alien woodwasp, threat to US pine trees, found in N.Y.
...hrough thousands of bark beetles caught in routine screening traps set by the New York State Cooperative Agricultural Pest Survey (CAPS) program, in search of any of 10 exotic species of bark beetles, when he stumbled across the specimen of S. noctilio . "I recognized it immediately," says Hoebeke, a taxono...Dye to pinpoint diseases and pathogens
...ty of Toronto researchers have designed a chemical screening tool that will light up when dangerous pathogens a...try is ready to test the next sample. The chemical screening system fits onto a microchip and soon could test blood and water samples in a matter of seconds. Kru...More than 'SNARE' needed for proper synapse
...er. They identified this protein through a special screening procedure in fruit flies that allows them to identify functional defects in the fly eye. They found that the mutant fly eyes that lacked Vha100-1 were blind, indicating that information was not being communicated, said Bellen. Using molecular genet...Study finds research participants concerned about genetic discrimination
.... All participants were involved in primary-care screening for iron overload or hereditary hemochromatosis (a...ied the genes for hereditary hemochromatosis. The screening took place in Birmingham, Ala., Orange County, Calif., Washington, D.C., Honolulu, Hawaii, Portland,...Applied NeuroSolutions biomarker may predict Alzheimer's disease progression
...The company is also developing a blood serum-based screening test, as well as a new class of therapeutics to treat AD. Alzheimer's disease currently afflicts over 4 million Americans, and the market for AD therapy is expected to grow to 21 million patients by 2010 in the seven major pharmaceutical markets (US...New understanding of DNA repair may pave way to cancer treatments
...th in mouse models. Ongoing studies are devoted to screening for compounds that mimic the peptide's actions and to allow for further development of the peptide toward clinical assessment. "Until our recent studies, we were certain that the mechanism by which ATF2 affects melanoma growth was primarily through...Genetic variation alters response to common anti-clotting drug
...ieder said there's a high probability that genetic screening for the VKORC1 gene could result in better warfarin dosing, they agreed that more studies need to be done first. "What we've done is the basic science," said Rettie. "This complete genetic analysis of VKORC1 provides the mechanistic framework and ......ng highly sensitive instrumentation, sophisticated screening capabilities and discoveries from mapping the huma... biologically active molecules and high-throughput screening techniques. Most of Molinski's samples come from sponges and tunicates, marine creatures that can ne...Results of world's first gene therapy trial for arthritis show approach safe, feasible
..., reintroduced several weeks later after intensive screening and determination of gene expression. "Given that ... seven weeks later, following extensive laboratory screening of the genetically modified cells, patients returned to the clinic, where the cells were injected in...Joslin scientists confirm link between PKC enzyme and kidney disease in diabetes
...c and nondiabetic mice models - using conventional screening and diagnostic tests to assess the progression of kidney disease in each model. In diabetes, hyperglycemia overactivates PKC-beta and gradually damages the microvessels of the kidney. Over time, tiny capillaries known as glomeruli become so porous t...ANU medical researcher wins national award
...orce in this genome research, with its program for screening hundreds of thousands of gene sequences and making them accessible to medical researchers around the world. It has already led to a number of breakthroughs at ANU in one of the largest health problems in the community - dysfunction of the immune syst...MicroRNA tweaks protein that controls early heart development
..." The UT Southwestern research team is currently screening human patients with congenital heart disease for mutations in the gene miR-1 to determine what health effects such a mutation might cause. They also are studying mice and fruit flies lacking miR-1. Dr. Srivastava said the field of microRNA studies ...Treating pregnancy-related diabetes is a win-win for mum and baby
... that until now there has been uncertainty whether screening and treatment of mild gestational diabetes to redu...large randomised clinical trials on the effects of screening and subsequent treatment of women with mild gestational diabetes," Prof Crowther said. "Our results ......uture improvements in therapy. However, population screening for kidney disease risk is still best focused on diabetes, hypertension and protein in the urine." The study involved 14,520 middle-aged whites and African Americans enrolled in the Atherosclerosis Risk in Communities study. Participants underwent s...