Scripps research scientists show protein accelerates breast cancer progression in animal models
... ... The study also found that the expression of pleiotrophin activated surrounding cells to remodel the tumor microenv...Scripps Research study reveals new function of protein kinase pathway in tumor suppression
... The research focused on signaling pathways that mediate an anti-tumor defense response called senescence, or cellular aging. The research, which was conducted in both human cell culture and rodent models with skin cancer or lymphoma, identified one essential element of this anti-tumor response, namely, p38-regulated/activated protein kinase (PRAK). Previous to this research, PRAK's physiolo...Study led by Scripps Research scientist reveals little-known cell networks vital to circadian rhythm
... By examining effects of genetic mutations at the level of single cells and tissues, the study showed that intercellular me...Scripps research team sheds light on long-sought cold sensation gene
... "This study represents the first demonstration that a single gene is responsible for most cool temperature sensation," says team leader Ardem Patapoutian, who has joint appointments with the Department of Cell Biology at Scripps Research and the Genomics Institute of the Novartis Research Foundation. "Many previous candidates have been postul...Scripps research study shows humans and plants share common regulatory pathway
... The study provides new evidence that Nod1, a member of the Nod-like Receptor (NLR) protein family, is activated by the protein SGT1, which also activates Resistance (R) proteins in plants; R proteins protect plants from various pathogens. The study also confirms structural similarities between the Nod1 protein, which plays a pivotal role in the innate immune systems recognition and response...Scripps research scientists identify new regulatory mechanism for critical protein signaling domain
... In findings the authors called "unexpected and striking," the study found that a new regulating messenger IP4, a small soluble molecule, augments the binding of three different PH domain proteins to one of the most commonly recognized membrane lipids, PIP3. The study also showed that inhibiting production of IP4 can result in reduced protein binding to membranes and reduced activation of k...Scripps research team discovers a chemical pathway that causes mice to overeat and gain weight
... The EP3 receptor is one of four types of receptors for prostaglandin E2 (PGE2), the most important inflammatory mediator that controls a variety of physiological functions including fever, fertility, and blood pressure. The most common...Scripps research study reveals structural dynamics of single prion molecules
... Intriguingly, certain prions and amyloids can play beneficial roles. The subject of the new study, Sup35, enables protein-based inheritance in yeast. When this prion protein misfolds, it converts into self-perpetu...Scripps research scientists: Compounds show significant promise against potential bioweapon toxins
... ... "Our study is an important milestone in the fight against biological terrorism," said Kim Janda, a Scripps Research scientist who led the study. "These small molecules are the first to show efficacy agains...Scripps Research study reveals new activation mechanism for pain sensing channel
... The researchers found that TRPA1, a protein that helps transmit pain signals, is a direct sensor of reactive chemicals. "While many noxious and pungent compounds were known to activate this pain receptor, we discovered that they do so by directly and irreversibly binding to the cysteine amino acids of this protein," said Ardem Patapoutian, a Scripps Research scientist whose laboratory cond...NYU, Scripps finding offers new path for treatment of diabetes
... ... The research team, which included NYUs Departments of Biology and C...Reduced body temperature extends lifespan in study from the Scripps Research Institute
... Prior to this study, researchers had known that core body temperature and aging were related in cold-blooded animals. Scientists had also known that lifespan could be extended in warm-blooded animals by reducing the number of calories they consumed, which also lowered core body temperature. But the degree of cal...CU, Scripps researchers provide evidence of how proteins fold
Experimental evidence provided by a Cornell researcher and colleagues at the Scripps Research Institute in La Jolla, Calif., support a long-held theory of how and where proteins fold to create their characteristic shapes and biological functions.... The theory proposes that proteins start to fold in specific places along an amino acid chain (called a polypeptide chain) that contains nonpolar gro...Scripps marine research physiologist pioneer to receive lifetime achievement award
Gerald Kooyman, emeritus professor of biology at Scripps Institution of Oceanography at the University of California, San Diego, will be the first recipient of a new lifetime achievement award bestowed by the Society for Marine Mammalogy during the society's 16th Biennial Conference on the Biology of Marine Mammals.... ...The presentation of the Kenneth S. Norris Lifetime Achievement Award to Koo...NIH awards $4.2 million grant to scientists at Scripps Research to speed DNA sequencing technologies
A team of scientists at The Scripps Research Institute in California and Oxford University in England have been awarded a $4.2 million five-year grant to conduct basic science aimed at speeding the rate at which the next generation of DNA sequencing technologies will become available to scientists and clinicians.... ...This award is part of a larger initiative announced today by the National Hum...New Scripps Oceanography project to study sediments and ecosystem restoration in Venice lagoon
Scripps Institution of Oceanography at the University of California, San Diego, in conjunction with Italy's Venice Water Authority, Consorzio Venezia Nuova and Thetis SPA, has launched a multifaceted scientific program aimed at providing fundamental information about the effects of sediment translocation in Venice lagoon, a vital facet of the historic city of Venice, Italy....... The new effort,...Scripps research-based center awarded more than $50 million by NIH to solve protein structures
A consortium of scientists at The Scripps Research Institute and several other California institutions has been awarded a $52.7 million grant by the National Institute of General Medical Sciences (NIGMS), part of the National Institutes of Health. The grant is part of the second phase of a $600 million national effort called the Protein Structure Initiative that ultimately seeks to find the three...Scripps research scientists discover new key to pulmonary edema in respiratory distress syndrome
La Jolla, CA, June 28, 2005--Physiology is sometimes a crossroads where many different paths converge. Such is the case with acute respiratory distress syndrome, a severe and often fatal condition also known as adult respiratory distress syndrome or simply "shock lung."...... Acute respiratory distress syndrome can be caused by a number of underlying conditions, including smoke inhalation, a seve...Scripps scientists identify target of an immune suppression molecule called CD22itself
Scientists at The Scripps Research Institute have applied an innovative approach to studying human proteins that bind to sugar molecules on the surface of human cells to discover how one crucial aspect of our immune system works. They identified the target of a regulatory molecule called CD22 that is expressed on the surface of the type of immune system cell known as the B lymphocyte.... ...B lym...Scripps research scientists solve structure of a critical innate immune system protein
Scientists at The Scripps Research Institute have solved the structure of a crucial human immune system molecule called TLR3, an acronym for Toll-like receptor three. In an upcoming issue of the journal Science, the protein is described as a large horseshoe-shaped coil composed of 23 leucine-rich repeats (LRRs). ......The structure reveals details of TLR3 that have never been seen before, an ess...NIH awards $10.4 million to Scripps Research Institute and Scripps Florida
A group of researchers at the La Jolla, California, and Palm Beach County, Florida, campuses of The Scripps Research Institute has been awarded a $10.4 million dollar grant from the National Institutes of Health (NIH) to establish The Scripps Research Institute Molecular Screening Center. This is a pilot program to discover small molecule tools for translating basic biomedical discoveries more qu...Vampires beware: Scripps scientists describe molecular basis of raw garlic's pungency
Cooked or raw, garlic has been a favorite ingredient of cooks for thousands of years, but almost any cook will tell you there's a major difference: raw garlic is much more pungent than cooked.... ...Now, a group of scientists from The Scripps Research Institute, the Genomics Institute of the Novartis Research Foundation, and the Korea University College of Medicine is explaining the biological b...Scripps scientists find potential for catastrophic shifts in Pacific ecosystems
Opening the door to a new way of understanding ocean processes and managing and protecting marine resources, a group of researchers at Scripps Institution of Oceanography at the University of California, San Diego, has developed a groundbreaking analysis of the North Pacific Ocean and how dramatic changes can unfold across its waters. ...The study, published in the May 19 issue of the journal Nat...To stop evolution: New way of fighting antibiotic resistance demonstrated by Scripps scientists
A team of scientists at The Scripps Research Institute and the University of Wisconsin have demonstrated a new way of fighting antibiotic resistance: by stopping evolution. ... ...In the June issue of the open-access journal PloS Biology, the team describes how a protein called LexA in the bacterium Escherichia coli promotes mutations and helps the pathogen evolve resistance to antibiotics. The...Scripps Nierenberg Prize awarded to nature filmmaker Sir David Attenborough
The fifth annual award honoring the memory of William A. Nierenberg, who led Scripps Institution of Oceanography, UCSD, as director for more than two decades, will be awarded to celebrated BBC nature filmmaker Sir David Attenborough....... Attenborough will receive the Nierenberg Prize for Science in the Public Interest during a ceremony on Sunday, June 5, at 1 p.m., in front of the Birch Aquariu...Scripps scientists describe protein used by bacteria and cancer cells to resist drugs
Scientists at The Scripps Research Institute have solved the structure of a protein called MsbA that is involved in resisting antibiotics and chemotherapy. ... ...The structure of this membrane transporter protein is described in the current issue of the journal Science. Bacteria use these transporters to nullify antibiotics, and human cancer cells have similar membrane transporters on their sur...Scripps research scientists identify infertility molecule
Scientists at The Scripps Research Institute are reporting that mice created to lack a certain type of molecule known as an LPA receptor have fertility problems, which suggests that these receptors play a major role in conception.... ...In the latest issue of the journal Nature, the scientists detail how mice that lack LPA receptors, which normally appear on the surface of cells in a mouse's wom...Antibody that neutralizes most HIV strains described by scientists at The Scripps Research Institute
A group of scientists from The Scripps Research Institute and several other institutions has solved the structure of a rare human antibody that broadly neutralizes human immunodeficiency virus (HIV), which causes acquired immunodeficiency syndrome (AIDS). ... ...Neutralizing antibodies are soluble proteins that are secreted by adaptive immune cells into the bloodstream, following exposure to a v...NIH awards new $14.5 million, five-year grant to the Scripps Research Institute
The Scripps Research Institute announced today that it has been awarded a $14.5 million, five-year grant from The National Institute of General Medical Sciences (NIGMS), a component of the National Institutes of Health (NIH). The grant, which is titled "JCSG Center for Innovative Membrane Protein Technologies," funds structural biology research on membrane proteinsan area of immense medical poten...