NIH awards new $14.5 million, five-year grant to the Scripps Research Institute
...under which this has worked in the past are highly sensitive to such variables as detergent type, concentration, pH, and ionic strength. And these conditions are also almost always unique, demanding a lengthy trial and error search for those exact conditions in which the protein-detergent complexes will be sol...US researchers show cottonseed drug is cancer treatment booster
... (programmed cell death) and made the tumours more sensitive to radiotherapy in human prostate tumours in mice. The study demonstrates for the first time that (-)-gossypol enhances the anti-tumour efficacy of radiation therapy both in vitro and in vivo with increased induction of apoptosis. Dr. Xu explained: "...Commandeering cellular machinery: recognition mechanism to detect small molecules
...their responsiveness, with some significantly more sensitive than others. Some performed the function of on-of...nsing arrays in which a variety of receptors, each sensitive to a different compound, could be used to quickly analyze an unknown agent. A sensor array might al...College students recognized & rewarded for their innovative work
...aterials. Because their invention is so much more sensitive and precise than previous types of tests, it could be used to detect chemical signs of Alzheimer's disease, Mad Cow Disease, or types of cancer far earlier than conventional tests. Their advisor on this project is Dr. Chad Mirkin, who receives a $5,0...A treatment, not a cure: Calcium silicate neutralizes an acidic stream
...g short-term methods of restoring water quality to sensitive sites." Symptoms of acidified streams include a drop in pH, calcium, and dissolved inorganic carbon and an increase in metals like aluminum. When pH-levels decline, a stream is said to have lost its acid neutralizing capacity (ANC). Aquatic and semi...NIH awards Emory and Georgia Tech $10 million for partnerships in cancer nanotechnology
...p advanced nanoparticle technologies for extremely sensitive profiling of biomarkers on cancer cells and tissue...aditional pathology and cancer biology with highly sensitive molecular analysis. In addition to basic knowledge on cancer biology and biomarkers, the Bioeng...UF scientists have bionanotechnology recipe to find elusive bacteria
... in a sample, but traditional methods are not very sensitive -- the glow from one antibody-linked dye molecule ...technology," he said. "In situations when the very sensitive detection of bacteria or other biological reagents is the critical issue, I think our technology wil...Amphibians in dramatic decline; Up to 122 extinct since 1980
...ce their highly permeable skin is more immediately sensitive to changes in the environment, including changes to freshwater and air quality. "Amphibians are one of nature's best indicators of overall environmental health," said Russell A. Mittermeier, president of Conservation International (CI). "Their cat...Scientists identify new cause of obesity
...rly, this receptor is crucial to the body's highly sensitive ability to balance food intake and energy expenditure," Vaisse said. In the on-going UCSF Genetics of Human Obesity Study directed by Vaisse, researchers have so far studied the genetic profiles of about 2,000 patients. Of these, 50 have been found t...Discovery might improve design, effectiveness of anti-cancer drugs
...ratory studies, Wolfenden said. Since it is highly sensitive and accurate, mass spectrometry is a major analytical tool capable of sequencing peptides and allowing researchers to identify and characterize proteins at their physiological level. The instrument in which the experiments were performed is located a...International human genome sequencing consortium describes finished human genome sequence
...h the high coverage and accuracy needed to perform sensitive analyses, such as focusing on the number of genes, the segmental duplications involved in disease and the "birth" and "death" of genes over the course of evolution. "Only a decade ago, most scientists thought humans had about 100,000 genes. When we ...Clues to improving TB treatment
...otein sidelined, tuberculosis bacteria become more sensitive to treatment by a "second-line" drug called ethionamide, or ETH. Second-line drugs such as ETH may prove useful in treating multidrug-resistant strains of tuberculosis that have already outwitted the usual battery of "first-line" tuberculosis dru...Brain differences in adolescents, psychopaths, lend to their impulsive, risk-taking behavior
...cortex and more activation in the brain structures sensitive to error monitoring and reward," says Fishbein. "These activations suggest a lack of frontal inhibitory control over risky decisions." ......und. MEG is a noninvasive technique that is highly sensitive to the brain's response to sounds. This work is among very few MEG studies carried out with autistic children. The researchers measured a brain response called the M100, a neuromagnetic signal that reflects the cortex's activity after a soun...Calorie restriction leads to some brain benefits but not others in mice
...reverse some of the effects of aging. "We believe sensitive signaling pathways that are particularly important in the brain are disrupted by high levels of free radicals and that these disruptions may explain why, under normal circumstances, brain function declines over time," Dugan says. "Fortunately, it wou...Soaking up signal: Endocytosis controls spreading and effective signaling range of Fgf8 protein
... because cells in developing tissues are extremely sensitive to such protein signals, and thus the range of these signals within a given tissue must be precisely regulated to prevent morphological defects from arising during development. Fibroblast Growth Factors are a group of signaling molecules that influen...Munching microbes could cleanse arsenic-contaminated groundwater
...he presence of arsenic which generally requires a sensitive laboratory analysis testing for sulfate is simple and straightforward," Bethke said. "If all waters containing sulfate are safe, as in our dataset, then measuring sulfate level would be an easy but reliable field test to identify safe drinking wate...Warning from new SLU research: Usual test for vitamin deficiency can mislead doctors
...asure the amount of vitamin B12 in the body is not sensitive enough to detect a deficiency of the vitamin, which has been linked to several neurological conditions, according to Saint Louis University research. The findings were presented this month at a meeting of the American Neurological Association. ...Genetically endowed worm may substitute for rodents in some toxicology testing
.... So the idea is to develop an inexpensive, fairly sensitive screen that can give us guidance on what to test." "Potentially, if we get enough information put together and we feel comfortable enough with C. elegans, it may in fact replace the rodent. But for now what we're looking for is something...Research to explore revolutionary gene sequencing: Threading the molecular needle
...olecular resolution with the ultra-small tip of a sensitive probe, in combination with naturally occurring rin...ay's technology proposes to attach the ring to the sensitive AFM tip, which would thread an anchored DNA molecule into the ring and pull it through, recording t...