Tag: "sensitive" at biology news

Why some lung cancers stop responding to Tarceva and Iressa

...uld confer resistance to the EGFR mutants normally sensitive to these drugs. "It is especially interesting that the mutation we found is strictly analogous to a mutation that makes other kinds of tumors resistant to another targeted therapy, imatinib mesylate (Gleevec)," said Harold Varmus, President of MSKCC ...

Individual taste receptor variations determine 'classic' PTC bitterness perception

... of their specific PTC taste receptor. To test how sensitive different versions of the receptor were to the compounds, the researchers introduced different alleles of the gene into cultured cells, which then expressed the corresponding taste receptor protein. A specialized assay allowed the researchers to det...

'Blinding' an insect's sense of smell may be the best repellent

...lion years evolution "While all these insects have sensitive olfactory systems, they all have very different smell preferences," says Vosshall, head of the Laboratory of Neurogenetics and Behavior. "Yet this odorant receptor is highly conserved across all of these different species." Vosshall's laboratory pre...

Individual differences in taste perception directly related to genetic variation in taste receptors

...e with the PAV form of the hTAS2R38 gene were most sensitive to the bitter taste of PROP and PTC. Subjects homo... for the AVI haplotype were 100 to 1000 times less sensitive to bitter taste of the two compounds, confirming the lack of response in the cell culture experiment...

Inflammatory molecules released by pollen trigger allergies

...s whether cells from allergy-prone people are more sensitive to the effects of the pollen-derived compound than those from non-allergic individuals. A better understanding of these molecules and how they work may eventually lead to new approaches to treating allergies....

UNC findings may help explain cause of most common movement disorder

...e same effect in these mice - they are exquisitely sensitive to alcohol," said Morrow. Additional compounds that ease the symptoms of essential tremor in humans, such as the anticonvulsant primidone and the beta-blocker propranolol, also had partial alleviating effects in the mutant mice. "The work by the Morr...

Researchers uncover mutated genes involved in lung cancer; one affects nonsmokers

...ese tumors can vary by several thousandfold on how sensitive they are to a drug," said Dr. Minna. "We also have... tells whether a tumor is going to be resistant or sensitive to a particular drug. We want to be capable of examining a patient's tumor, profile each human gene ...

Research may provide ways to inhibit cancer's ability to resist treatments

... the strand break ends. Without it, cells are more sensitive to agents such as ionizing radiation or certain drugs that kill cells by damaging their DNA. DNA, or deoxyribonucleic acid, is a large molecule shaped like a double helix found primarily in the chromosomes of the cell nucleus and contains the genetic...

Compound inhibits one critical pathway in breast cancer growth

... activated Stat3 pathway may make tumor cells more sensitive to chemotherapy," Lin said. He and his colleagues will continue to study the effects of STA-21 and related compounds, or analogs, in different types of cancer cells. "An analog of STA-21 could work even better," he said. "We may be able to create one...

Finding hidden invaders in a Hawaiian rain forest

...t or satellite approaches, but the new methods are sensitive to its high water content. In addition, the aircraft-based analysis discovered that ginger reduces the amount of nitrogen in the Metrosideros forest canopy--a discovery that was later corroborated by ground-based sampling. Peter Vitousek from Stanfo...

Asthma relapse in children common, possible risk factors identified

... The study also found that children who were more sensitive to house dust mites and cat allergens and/or had poor lung function were significantly less likely to experience asthma remission by the time they were age 18. Of those in remission at age 18, the poorer their lung function, the more likely they wer...

Acid rain likely stunts US forests

...of New York, have soils that are likely to be more sensitive to acid rain than those studied in Russia. Lawrence said that these findings also broaden the question of recovery from acid rain beyond that of just surface waters. Details of the study have been posted in the March web version of Environmental,...

Using molecular technique, researcher identify hospital pool bacterial pathogen

...e in the pool for up to four hours and the skin is sensitive to chlorine when exposed to it that long. Lifeguards became ill because they were exposed to the bacteria in aerosols eight hours daily, five days a week. No patients became ill at the hospital, which must remain anonymous. "The pr...

Environmental crisis forging strange bedfellows

...an attempt to get consumers into more ecologically sensitive cars," says Scharper, maintaining that this shows that, "both scientists and theologians are bridging the boundaries of science and religion when it comes to the environmental crisis." Scharper will deliver a lecture of his views at the Walter Gordon...

New lab technique identifies high levels of pathogens in therapy pool

...he technique used in the study is 1,000 times more sensitive than standard microbe-culturing techniques used at most indoor pool facilities today, the researchers said. The two-year study involved a molecular survey of a common RNA gene found in all life forms, eventually matching some cloned and sequenced ba...

Polymers with copper show promise for implanted sensors

...In some instances, the chemistry in the polymer is sensitive to moisture and heat, so whether it can be easily commercialized is one of the big issues," he said. In addition, the polymer coating must be very thin for most biomedical applications, which limits the amount of nitric oxide that can be stored and r...

Antioxidant blood levels key to MnSOD gene

...t a specific genetic variation that's particularly sensitive to oxidative stress. Conversely, if carriers of th...notype, people with the AA genotype seemto be more sensitive to the antioxidant status," said Li. "Men with the AA genotype are moresusceptible to prostate canc...

NYU study reveals how brain's immune system fights viral encephalitis

...ll culture, the researchers found that neurons are sensitive to the protective effect of interferons, inducing pathways to fight the virus' spread. However, their findings showed that interferons fight the virus at different stages of the virus' life cycle. First, they inhibit viral RNA and protein synthesis. ...

Tips from the Journals of the American Society for Microbiology

...monstrated here that replication of HBV and HCV is sensitive to the antiviral activities of interferon lambda," say the researchers. "These results suggest the possibility that interferon lambda may be therapeutically useful in the treatment of chronic HBV or HCV infection." (M.D. Robek, B.S. Boyd, F.V. Chisa...

Study of genomic DNA leads to new advances in cancer diagnostics

...stance to DNA digestion. Non-malignant cells were sensitive to DNA digestion by Alu I while highly malignant c... cell, influenced whether the cell's chromatin was sensitive or resistant to Alu I. The group also implicated the cell's cytoskeleton, the internal scaffolding ...

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(Date:10/31/2014)... 2014  HITLAB SM , a healthcare innovation ... inaugural HITLAB Innovators Summit SM on December ... will partner with the Clinton Foundation,s Health Matters ... Columbia Business School Alumni Club of ... and Operations Research, bringing together leaders in healthcare ...
(Date:10/30/2014)... animals begin life, cells immediately begin accepting assignments to ... mammals, including humans, are special. The cells of mammalian ... to become the protective placenta or to commit to ... step that research from Michigan State University has revealed ... of PLOS Genetics , provide insights ...
(Date:10/30/2014)... in the gastrointestinal tract fulfill many vital functions ... bacteria can induce strong inflammatory responses by the ... enter the bloodstream. , Although acute inflammation is ... or systemic inflammation is linked to numerous disorders ... of inflammatory processes in the development of psychiatric ...
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